Facile Synthesis of 4-O-β-N-Acetylchitooligosyl 2-acetamido-2,3-dideoxydidehydro-gluconolactone Based on the Transformation of Chitooligosaccharide and Its Suppressive Effects against the Furylfuramide-Induced SOS Response

A facile synthesis method is described for transforming the reducing-end residue of chitooligosaccharides (DP 2-4) into lactone. The desired 4-O-β-N-acetylchitooligosyl lactones (GN n L) were conveniently prepared from chitooligosaccharides by consecutive dehydration and oxidation reactions to affor...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2012, Vol.76 (7), p.1362-1366
Hauptverfasser:	OGATA, Makoto, TAKEUCHI, Ryota, SUZUKI, Akari, HIRAI, Hirofumi, USUI, Taichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimutagenic Agents - chemical synthesis Antimutagenic Agents - pharmacology Biological and medical sciences chitin Chitin - chemistry chitooligosaccharide Chromatography, High Pressure Liquid Fundamental and applied biological sciences. Psychology Furylfuramide - pharmacology Microbial Sensitivity Tests Mutagens - pharmacology Oligosaccharides - chemical synthesis Oligosaccharides - chemistry Oligosaccharides - pharmacology Oxidation-Reduction Salmonella typhimurium - drug effects Salmonella typhimurium - growth & development SOS Response (Genetics) - drug effects SOS-inducing activity transformation umu test
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