Effects of Methoxsalen from Poncirus trifoliata on Acetylcholinesterase and Trimethyltin-Induced Learning and Memory Impairment

Previously, we identified methoxsalen (8-methoxy-2′,3′,6,7-furocoumarin) as the bioactive compound probably responsible for acetylcholinesterase (AchE) inhibition achieved by feeding crude extract of Poncirus trifoliate. To confirm the activity of methoxsalen, Institute of Cancer Research (ICR) mice...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2011, Vol.75 (10), p.1984-1989
Hauptverfasser:	KIM, Jae Kyeom, CHOI, Soo Jung, BAE, Hyeri, KIM, Cho Rong, CHO, Hong-Yon, KIM, Young Jun, LIM, Seung Taik, KIM, Chang-Ju, KIM, Hye Kyung, PETERSON, Sabrina, SHIN, Dong Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholinesterase Acetylcholinesterase - metabolism Alzheimer's disease Animals anti-oxidative activity Avoidance Learning - drug effects Biochemistry Biomedical materials Brain Brain - drug effects Brain - pathology Brain - physiopathology Cholinesterase Inhibitors - isolation & purification Cholinesterase Inhibitors - pharmacology Cholinesterase Inhibitors - therapeutic use Diet Diets Impairment Learning Learning - drug effects Maze Learning - drug effects Memory Disorders - chemically induced Memory Disorders - drug therapy Memory Disorders - pathology Memory Disorders - physiopathology methoxsalen (8-methoxy-2′,3′,6,7-furocoumarin) Methoxsalen - isolation & purification Methoxsalen - pharmacology Methoxsalen - therapeutic use Mice Mice, Inbred ICR PC12 Cells Poncirus Poncirus - chemistry Poncirus trifoliata Rats Surgical implants Trimethyltin Compounds - toxicity
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