Novel 4,5-Dihydro-thiazinogeldanamycin in a gdmP Mutant Strain of Streptomyces hygroscopicus 17997
Novel geldanamycin derivative, 4,5-dihydro-thiazinogeldanamycin (3), was characterized from the gdmP mutant in Streptomyces hygroscopicus 17997, besides expected 4,5-dihydro-geldanamycin (2). The presence of this compound would suggest an unknown post-PKS modification in geldanamycin biosynthesis. C...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2011, Vol.75 (10), p.2042-2045 |
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| container_issue | 10 |
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| container_title | Bioscience, biotechnology, and biochemistry |
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| creator | LIN, Ling NI, SiYang WU, LinZhuan WANG, YiGuang WANG, YuCheng TAO, PeiZhen HE, WeiQing WANG, XiangJing |
| description | Novel geldanamycin derivative, 4,5-dihydro-thiazinogeldanamycin (3), was characterized from the gdmP mutant in Streptomyces hygroscopicus 17997, besides expected 4,5-dihydro-geldanamycin (2). The presence of this compound would suggest an unknown post-PKS modification in geldanamycin biosynthesis. Compound 3 exhibited moderate anti-HSV-1-virus activity and higher water solubility than geldanamycin (1). Cysteine served as a precursor to synthesize 3, whose formation required obligatory enzymatic assistance. |
| doi_str_mv | 10.1271/bbb.110361 |
| format | Article |
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The presence of this compound would suggest an unknown post-PKS modification in geldanamycin biosynthesis. Compound 3 exhibited moderate anti-HSV-1-virus activity and higher water solubility than geldanamycin (1). Cysteine served as a precursor to synthesize 3, whose formation required obligatory enzymatic assistance.</description><identifier>ISSN: 0916-8451</identifier><identifier>ISSN: 1347-6947</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.110361</identifier><identifier>PMID: 21979086</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject>4,5-dihydro-thiazinogeldanamycin ; Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; Benzoquinones - chemistry ; Benzoquinones - metabolism ; Biochemistry ; Biological and medical sciences ; biosynthesis ; Biotechnology ; Cysteine ; Derivatives ; Fundamental and applied biological sciences. Psychology ; gdmP ; geldanamycin ; Lactams, Macrocyclic - chemistry ; Lactams, Macrocyclic - metabolism ; Mutation ; Precursors ; Protein Engineering ; Solubility ; Strain ; Streptomyces - genetics ; Streptomyces - metabolism ; Streptomyces hygroscopicus ; Thiazines - chemistry ; Thiazines - metabolism</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2011, Vol.75 (10), p.2042-2045</ispartof><rights>2011 by Japan Society for Bioscience, Biotechnology, and Agrochemistry 2011</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c582t-8b503e1d5a76d8fa4f61672f68a11d3bc654bd349fe836ffd651dc6620a7ae483</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25386417$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21979086$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LIN, Ling</creatorcontrib><creatorcontrib>NI, SiYang</creatorcontrib><creatorcontrib>WU, LinZhuan</creatorcontrib><creatorcontrib>WANG, YiGuang</creatorcontrib><creatorcontrib>WANG, YuCheng</creatorcontrib><creatorcontrib>TAO, PeiZhen</creatorcontrib><creatorcontrib>HE, WeiQing</creatorcontrib><creatorcontrib>WANG, XiangJing</creatorcontrib><title>Novel 4,5-Dihydro-thiazinogeldanamycin in a gdmP Mutant Strain of Streptomyces hygroscopicus 17997</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>Novel geldanamycin derivative, 4,5-dihydro-thiazinogeldanamycin (3), was characterized from the gdmP mutant in Streptomyces hygroscopicus 17997, besides expected 4,5-dihydro-geldanamycin (2). 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Psychology</subject><subject>gdmP</subject><subject>geldanamycin</subject><subject>Lactams, Macrocyclic - chemistry</subject><subject>Lactams, Macrocyclic - metabolism</subject><subject>Mutation</subject><subject>Precursors</subject><subject>Protein Engineering</subject><subject>Solubility</subject><subject>Strain</subject><subject>Streptomyces - genetics</subject><subject>Streptomyces - metabolism</subject><subject>Streptomyces hygroscopicus</subject><subject>Thiazines - chemistry</subject><subject>Thiazines - metabolism</subject><issn>0916-8451</issn><issn>1347-6947</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0VuL1DAUB_Agijs7-uIHkIKIInbNae6PsusN1guozyXNZSZL28wmrVI_vRlmVkFEhEDC4Zdwcv4IPQB8Bo2AF13XnQFgwuEWWgGhouaKittohRXwWlIGJ-g05yuMS4HBXXTSgBIKS75C3Yf4zfUVfc7qi7BdbIr1tA36RxjjxvVWj3pYTBirsnS1scOn6v086XGqPk9Jl2L0-5PbTbE4l6vtskkxm7gLZs4VCKXEPXTH6z67-8d9jb6-fvXl_G19-fHNu_OXl7Vhsplq2TFMHFimBbfSa-o5cNF4LjWAJZ3hjHaWUOWdJNx7yxlYw3mDtdCOSrJGTw7v7lK8nl2e2iFk4_pejy7OuVVYQBkGbv5DYk5kGVKRT_8pQRCMBRVsTx_9Qa_inMby4xYoVZIq2uzVs4MyZUw5Od_uUhh0WlrA7T7NtqTZHtIs-OHxybkbnP1Fb-Ir4PER6Gx075MeTci_HSOS09LjGrGDC6OPadDfY-ptO-mlj-nmEvlLAz8BDvW3RA</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>LIN, Ling</creator><creator>NI, SiYang</creator><creator>WU, LinZhuan</creator><creator>WANG, YiGuang</creator><creator>WANG, YuCheng</creator><creator>TAO, PeiZhen</creator><creator>HE, WeiQing</creator><creator>WANG, XiangJing</creator><general>Japan Society for Bioscience, Biotechnology, and Agrochemistry</general><general>Japan Society for Bioscience Biotechnology and Agrochemistry</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TB</scope><scope>7U5</scope><scope>8FD</scope><scope>FR3</scope><scope>L7M</scope><scope>7X8</scope><scope>7QL</scope><scope>7QO</scope><scope>C1K</scope><scope>P64</scope></search><sort><creationdate>2011</creationdate><title>Novel 4,5-Dihydro-thiazinogeldanamycin in a gdmP Mutant Strain of Streptomyces hygroscopicus 17997</title><author>LIN, Ling ; NI, SiYang ; WU, LinZhuan ; WANG, YiGuang ; WANG, YuCheng ; TAO, PeiZhen ; HE, WeiQing ; WANG, XiangJing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c582t-8b503e1d5a76d8fa4f61672f68a11d3bc654bd349fe836ffd651dc6620a7ae483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>4,5-dihydro-thiazinogeldanamycin</topic><topic>Bacterial Proteins - genetics</topic><topic>Bacterial Proteins - metabolism</topic><topic>Benzoquinones - chemistry</topic><topic>Benzoquinones - metabolism</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>biosynthesis</topic><topic>Biotechnology</topic><topic>Cysteine</topic><topic>Derivatives</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gdmP</topic><topic>geldanamycin</topic><topic>Lactams, Macrocyclic - chemistry</topic><topic>Lactams, Macrocyclic - metabolism</topic><topic>Mutation</topic><topic>Precursors</topic><topic>Protein Engineering</topic><topic>Solubility</topic><topic>Strain</topic><topic>Streptomyces - genetics</topic><topic>Streptomyces - metabolism</topic><topic>Streptomyces hygroscopicus</topic><topic>Thiazines - chemistry</topic><topic>Thiazines - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LIN, Ling</creatorcontrib><creatorcontrib>NI, SiYang</creatorcontrib><creatorcontrib>WU, LinZhuan</creatorcontrib><creatorcontrib>WANG, YiGuang</creatorcontrib><creatorcontrib>WANG, YuCheng</creatorcontrib><creatorcontrib>TAO, PeiZhen</creatorcontrib><creatorcontrib>HE, WeiQing</creatorcontrib><creatorcontrib>WANG, XiangJing</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LIN, Ling</au><au>NI, SiYang</au><au>WU, LinZhuan</au><au>WANG, YiGuang</au><au>WANG, YuCheng</au><au>TAO, PeiZhen</au><au>HE, WeiQing</au><au>WANG, XiangJing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel 4,5-Dihydro-thiazinogeldanamycin in a gdmP Mutant Strain of Streptomyces hygroscopicus 17997</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2011</date><risdate>2011</risdate><volume>75</volume><issue>10</issue><spage>2042</spage><epage>2045</epage><pages>2042-2045</pages><issn>0916-8451</issn><issn>1347-6947</issn><eissn>1347-6947</eissn><abstract>Novel geldanamycin derivative, 4,5-dihydro-thiazinogeldanamycin (3), was characterized from the gdmP mutant in Streptomyces hygroscopicus 17997, besides expected 4,5-dihydro-geldanamycin (2). The presence of this compound would suggest an unknown post-PKS modification in geldanamycin biosynthesis. Compound 3 exhibited moderate anti-HSV-1-virus activity and higher water solubility than geldanamycin (1). Cysteine served as a precursor to synthesize 3, whose formation required obligatory enzymatic assistance.</abstract><cop>Tokyo</cop><pub>Japan Society for Bioscience, Biotechnology, and Agrochemistry</pub><pmid>21979086</pmid><doi>10.1271/bbb.110361</doi><tpages>4</tpages></addata></record> |
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| ispartof | Bioscience, biotechnology, and biochemistry, 2011, Vol.75 (10), p.2042-2045 |
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| source | J-STAGE Free; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | 4,5-dihydro-thiazinogeldanamycin Bacterial Proteins - genetics Bacterial Proteins - metabolism Benzoquinones - chemistry Benzoquinones - metabolism Biochemistry Biological and medical sciences biosynthesis Biotechnology Cysteine Derivatives Fundamental and applied biological sciences. Psychology gdmP geldanamycin Lactams, Macrocyclic - chemistry Lactams, Macrocyclic - metabolism Mutation Precursors Protein Engineering Solubility Strain Streptomyces - genetics Streptomyces - metabolism Streptomyces hygroscopicus Thiazines - chemistry Thiazines - metabolism |
| title | Novel 4,5-Dihydro-thiazinogeldanamycin in a gdmP Mutant Strain of Streptomyces hygroscopicus 17997 |
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