Stereochemical Differentiation in the Simmons-Smith Reaction for Cyclopropanated Glucopyranose Derivatives as Molecular Probes for Glycosidases

Glucopyranose analogues carrying a bicyclo[4.1.0]heptane framework (4) and the diastereomer of the cyclopropane moiety were synthesized as the unit for molecular probes to mimic the unstable transition state conformation of the glucopyranose ring in enzymatic hydrolysis. The synthesis features diffe...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2011, Vol.75 (7), p.1380-1382
Hauptverfasser:	AKIYAMA, Nanako, NOGUCHI, Shogo, HASHIMOTO, Masaru
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological and medical sciences Biotechnology Cyclopropane Cyclopropanes - chemistry Derivatives Differentiation Fundamental and applied biological sciences. Psychology glucopyranose Glucose - chemistry Glycosidases Glycoside Hydrolases - chemistry Hydrolysis Models, Molecular Molecular Conformation Molecular Probes - chemical synthesis Molecular Probes - chemistry Simmons-Smith reaction Stereoisomerism stereoselectivity Synthesis transition state analogue
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