Identification of Aromatic Residues Critical to the DNA Binding and Ligand Response of the Bacillus subtilis QdoR (YxaF) Repressor Antagonized by Flavonoids

Bacillus subtilis LmrA and QdoR (formerly YxaF) are paralogous transcriptional regulators that repress their regulon comprising the lmrAB operon, the qdoR gene, and the qdoI-yxaH operon, by binding to the LmrA/QdoR boxes located in the promoter regions. Detachment of them followed by derepression of...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2011, Vol.75 (7), p.1325-1334
Hauptverfasser:	HIROOKA, Kazutake, FUJITA, Yasutaro
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacillus subtilis Bacillus subtilis - genetics Bacillus subtilis - metabolism Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Binding Sites - genetics Biological and medical sciences DNA - analysis DNA - chemistry DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism flavonoid Flavonoids - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Bacterial Ligands Mutagenesis, Site-Directed - methods Promoter Regions, Genetic Protein Binding - genetics Repressor Proteins - antagonists & inhibitors Repressor Proteins - chemistry Repressor Proteins - genetics site-directed mutagenesis transcriptional regulator
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