Human brain harbors single nucleotide somatic variations in functionally relevant genes possibly mediated by oxidative stress

Somatic variation in DNA can cause cells to deviate from the preordained genomic path in both disease and healthy conditions. Here, using exome sequencing of paired tissue samples, we show that the normal human brain harbors somatic single base variations measuring up to 0.48% of the total variation...

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Veröffentlicht in:	F1000 research 2016, Vol.5, p.2520
Hauptverfasser:	Sharma, Anchal, Ansari, Asgar Hussain, Kumari, Renu, Pandey, Rajesh, Rehman, Rakhshinda, Mehani, Bharati, Varma, Binuja, Desiraju, Bapu K., Mabalirajan, Ulaganathan, Agrawal, Anurag, Mukhopadhyay, Arijit
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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