Lovastatin lactone may improve irritable bowel syndrome with constipation (IBS-C) by inhibiting enzymes in the archaeal methanogenesis pathway [version 1; peer review: 1 approved with reservations]

Methane produced by the methanoarchaeon Methanobrevibacter smithii ( M. smithii) has been linked to constipation, irritable bowel syndrome with constipation (IBS-C), and obesity. Lovastatin, which demonstrates a cholesterol-lowering effect by the inhibition of HMG-CoA reductase, may also have an ant...

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Veröffentlicht in:	F1000 research 2016, Vol.5, p.606
Hauptverfasser:	Muskal, Steven M, Sliman, Joe, Kokai-Kun, John, Pimentel, Mark, Wacher, Vince, Gottlieb, Klaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Macromolecular Chemistry Protein Chemistry & Proteomics
Online-Zugang:	Volltext
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