In search of the mechanisms of ketamine's antidepressant effects: How robust is the evidence behind the mTor activation hypothesis [version 1; peer review: 1 approved, 1 approved with reservations]

Extensive evidence on rapid and long-lasting antidepressant effects of intravenous ketamine motivated efforts to identify underlying mechanisms that would enable development of novel drugs with similar efficacy, but improved safety and pharmacokinetic profiles. It has been suggested that the antidep...

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Veröffentlicht in:	F1000 research 2016, Vol.5, p.634
Hauptverfasser:	Popp, Susanna, Behl, Berthold, Joshi, Jaya Julie, Lanz, Thomas A, Spedding, Michael, Schenker, Esther, Jay, Therese M, Svenningsson, Per, Caudal, Dorian, Cunningham, Jacob I, Deaver, Daniel, Bespalov, Anton
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Signaling Data Sharing Neuropharmacology & Psychopharmacology Pharmacokinetics & Drug Delivery
Online-Zugang:	Volltext
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