Deciphering the significance of neutrophil to lymphocyte and monocyte to lymphocyte ratios in tuberculosis: A case-control study from southern India [version 1; peer review: awaiting peer review]
Background Diagnosis of tuberculosis (TB) in resource-limited countries relies primarily on bacteriological confirmation using Ziehl-Neelsen (ZN) stain or culture. However, this method has low sensitivity due to suboptimal sampling and techniques. Neutrophils, monocytes, and lymphocytes are crucial...
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| Veröffentlicht in: | F1000 research 2024, Vol.13, p.747 |
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| creator | Bakshi, Poorva Nayak, Rakshatha Rai, Sharada Jayasheelan, Shikha |
| description | Background
Diagnosis of tuberculosis (TB) in resource-limited countries relies primarily on bacteriological confirmation using Ziehl-Neelsen (ZN) stain or culture. However, this method has low sensitivity due to suboptimal sampling and techniques. Neutrophils, monocytes, and lymphocytes are crucial in the pathogenesis of granulomatous inflammation and immune reactions. We investigated the usefulness of the haematological parameters and their ratios, like the Neutrophil to Lymphocyte ratio (NLR) and Monocyte to Lymphocyte ratio (MLR), for diagnosing tuberculosis.
Methods
We retrospectively grouped 114 patients with fever into those diagnosed with TB and control groups. We obtained their haematological data and calculated their derived ratios. The ratios obtained from the two groups were compared. Their sensitivity and specificity were calculated.
Results
Haematological parameters like MLR were higher in TB patients than in the control group. Although NLR was not significantly increased, MLR was significantly increased with p values |
| doi_str_mv | 10.12688/f1000research.150685.1 |
| format | Article |
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Diagnosis of tuberculosis (TB) in resource-limited countries relies primarily on bacteriological confirmation using Ziehl-Neelsen (ZN) stain or culture. However, this method has low sensitivity due to suboptimal sampling and techniques. Neutrophils, monocytes, and lymphocytes are crucial in the pathogenesis of granulomatous inflammation and immune reactions. We investigated the usefulness of the haematological parameters and their ratios, like the Neutrophil to Lymphocyte ratio (NLR) and Monocyte to Lymphocyte ratio (MLR), for diagnosing tuberculosis.
Methods
We retrospectively grouped 114 patients with fever into those diagnosed with TB and control groups. We obtained their haematological data and calculated their derived ratios. The ratios obtained from the two groups were compared. Their sensitivity and specificity were calculated.
Results
Haematological parameters like MLR were higher in TB patients than in the control group. Although NLR was not significantly increased, MLR was significantly increased with p values <0.05. These tests had low sensitivity but high specificity.
Conclusion
Serum NLR and MLR emerge as valuable tools in TB diagnosis. Their simplicity and cost-effectiveness render them particularly suitable for screening and recurrence monitoring in rural and remote settings, thereby mitigating loss to follow-up.</description><identifier>ISSN: 2046-1402</identifier><identifier>EISSN: 2046-1402</identifier><identifier>DOI: 10.12688/f1000research.150685.1</identifier><language>eng</language><ispartof>F1000 research, 2024, Vol.13, p.747</ispartof><rights>Copyright: © 2024 Bakshi P et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1491-9131c4140a05ab537e38fc94bcb2c93942e3422b44c1df2d9c89e1d09664540c3</cites><orcidid>0009-0007-0888-1614 ; 0009-0008-2554-7711 ; 0000-0002-7257-1465</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,861,4010,27904,27905,27906</link.rule.ids></links><search><creatorcontrib>Bakshi, Poorva</creatorcontrib><creatorcontrib>Nayak, Rakshatha</creatorcontrib><creatorcontrib>Rai, Sharada</creatorcontrib><creatorcontrib>Jayasheelan, Shikha</creatorcontrib><title>Deciphering the significance of neutrophil to lymphocyte and monocyte to lymphocyte ratios in tuberculosis: A case-control study from southern India [version 1; peer review: awaiting peer review]</title><title>F1000 research</title><description>Background
Diagnosis of tuberculosis (TB) in resource-limited countries relies primarily on bacteriological confirmation using Ziehl-Neelsen (ZN) stain or culture. However, this method has low sensitivity due to suboptimal sampling and techniques. Neutrophils, monocytes, and lymphocytes are crucial in the pathogenesis of granulomatous inflammation and immune reactions. We investigated the usefulness of the haematological parameters and their ratios, like the Neutrophil to Lymphocyte ratio (NLR) and Monocyte to Lymphocyte ratio (MLR), for diagnosing tuberculosis.
Methods
We retrospectively grouped 114 patients with fever into those diagnosed with TB and control groups. We obtained their haematological data and calculated their derived ratios. The ratios obtained from the two groups were compared. Their sensitivity and specificity were calculated.
Results
Haematological parameters like MLR were higher in TB patients than in the control group. Although NLR was not significantly increased, MLR was significantly increased with p values <0.05. These tests had low sensitivity but high specificity.
Conclusion
Serum NLR and MLR emerge as valuable tools in TB diagnosis. Their simplicity and cost-effectiveness render them particularly suitable for screening and recurrence monitoring in rural and remote settings, thereby mitigating loss to follow-up.</description><issn>2046-1402</issn><issn>2046-1402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFUdtO3DAQjaoiFQHfwPxAtrbjZGP2abVtAQmJl_YJociZjImrrB3ZzqJ8X3-soVsJeOJprufM6Jwsu-RsxUVV118NZ4wFiqQD9itesqouV_xTdiqYrHIumfj8Jv-SXcT4e0EwpYpKrE-zP98I7dhTsO4JUk8Q7ZOzxqJ2SOANOJpS8GNvB0gehnk_9h7nRKBdB3vvjsX7UdDJ-gjWQZpaCjgNPtp4BVtAHSlH7xbKAWKauhlM8HuIflqOBwe3rrMaHg4UovUO-AZGogCBDpaer0A_a5teXn3TfTzPToweIl38j2fZrx_ff-5u8rv769vd9i5HLhXPFS84ykUGzUrdlsWaitqgki22AlWhpKBCCtFKibwzolNYK-IdU1UlS8mwOMvWR14MPsZAphmD3eswN5w1_-xo3tnRHO1o-ILcHJFGL2Kk-WWreV37AP0XmCmYig</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>Bakshi, Poorva</creator><creator>Nayak, Rakshatha</creator><creator>Rai, Sharada</creator><creator>Jayasheelan, Shikha</creator><scope>C-E</scope><scope>CH4</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0009-0007-0888-1614</orcidid><orcidid>https://orcid.org/0009-0008-2554-7711</orcidid><orcidid>https://orcid.org/0000-0002-7257-1465</orcidid></search><sort><creationdate>2024</creationdate><title>Deciphering the significance of neutrophil to lymphocyte and monocyte to lymphocyte ratios in tuberculosis: A case-control study from southern India [version 1; peer review: awaiting peer review]</title><author>Bakshi, Poorva ; Nayak, Rakshatha ; Rai, Sharada ; Jayasheelan, Shikha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1491-9131c4140a05ab537e38fc94bcb2c93942e3422b44c1df2d9c89e1d09664540c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bakshi, Poorva</creatorcontrib><creatorcontrib>Nayak, Rakshatha</creatorcontrib><creatorcontrib>Rai, Sharada</creatorcontrib><creatorcontrib>Jayasheelan, Shikha</creatorcontrib><collection>F1000Research</collection><collection>Faculty of 1000</collection><collection>CrossRef</collection><jtitle>F1000 research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bakshi, Poorva</au><au>Nayak, Rakshatha</au><au>Rai, Sharada</au><au>Jayasheelan, Shikha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deciphering the significance of neutrophil to lymphocyte and monocyte to lymphocyte ratios in tuberculosis: A case-control study from southern India [version 1; peer review: awaiting peer review]</atitle><jtitle>F1000 research</jtitle><date>2024</date><risdate>2024</risdate><volume>13</volume><spage>747</spage><pages>747-</pages><issn>2046-1402</issn><eissn>2046-1402</eissn><abstract>Background
Diagnosis of tuberculosis (TB) in resource-limited countries relies primarily on bacteriological confirmation using Ziehl-Neelsen (ZN) stain or culture. However, this method has low sensitivity due to suboptimal sampling and techniques. Neutrophils, monocytes, and lymphocytes are crucial in the pathogenesis of granulomatous inflammation and immune reactions. We investigated the usefulness of the haematological parameters and their ratios, like the Neutrophil to Lymphocyte ratio (NLR) and Monocyte to Lymphocyte ratio (MLR), for diagnosing tuberculosis.
Methods
We retrospectively grouped 114 patients with fever into those diagnosed with TB and control groups. We obtained their haematological data and calculated their derived ratios. The ratios obtained from the two groups were compared. Their sensitivity and specificity were calculated.
Results
Haematological parameters like MLR were higher in TB patients than in the control group. Although NLR was not significantly increased, MLR was significantly increased with p values <0.05. These tests had low sensitivity but high specificity.
Conclusion
Serum NLR and MLR emerge as valuable tools in TB diagnosis. Their simplicity and cost-effectiveness render them particularly suitable for screening and recurrence monitoring in rural and remote settings, thereby mitigating loss to follow-up.</abstract><doi>10.12688/f1000research.150685.1</doi><orcidid>https://orcid.org/0009-0007-0888-1614</orcidid><orcidid>https://orcid.org/0009-0008-2554-7711</orcidid><orcidid>https://orcid.org/0000-0002-7257-1465</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; PubMed Central; EZB Electronic Journals Library; PubMed Central Open Access |
| title | Deciphering the significance of neutrophil to lymphocyte and monocyte to lymphocyte ratios in tuberculosis: A case-control study from southern India [version 1; peer review: awaiting peer review] |
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