EXPERIMENTAL STUDY FOR THE TOXICOLOGICAL EFFECTS OF SVATE-3 ON RAT KIDNEY-OBSERVATION BY LIGHT AND ELECTRON MICROSCOPE AND BY ENZYME HISTOCYTOCHEMISTRY
We have done an acute toxicological experiment on the rat kidney by administration of SVATE-3 in clinical dose (high and low dose, respectively) for 3 weeks. By using morphological methods, light and electron microscopy, enzyme morphological methods, light and electron microscopy, enzyme histocytoch...
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| Veröffentlicht in: | ACTA HISTOCHEMICA ET CYTOCHEMICA 1992, Vol.25(1-2), pp.175-179 |
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| creator | SHI, YU XIU LIU, Li HE, WEI ZHU, SHU WEN QI, WAN QIANG GAO, JUN FENG LIU, DONG JAN WANG, ZHAN YOU XU, YAN PING GUO, YU KUEN HAO, WEN XEU |
| description | We have done an acute toxicological experiment on the rat kidney by administration of SVATE-3 in clinical dose (high and low dose, respectively) for 3 weeks. By using morphological methods, light and electron microscopy, enzyme morphological methods, light and electron microscopy, enzyme histocytochemistry in light and electron microscope and biochemistry, we have observed the histological structure and ultrastucture of rat kidney as well as the activity and distribution of the index enzymes for the kidney cell membrane such as Mg-adenosine triphosphatase, 5′-nucleotidase, alkaline phosphatase and glucose-6-phosphatase for kidney cell organelle: endoplasmic reticulum. Futhermore, the biochemical quantitation has been given. The results show that there is no toxic damage to the histological structure and enzyme activity and distribution of rat kidney by administration of SVATE-3 in the low dose. But in high dose, the filter membrane of the kidney was damaged and the activity of Mg-ATPase were decreased. This suggests that we should pay more attention to SVATE-3′s toxicological threshold value when using it and get safe treatment. |
| doi_str_mv | 10.1267/ahc.25.175 |
| format | Article |
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By using morphological methods, light and electron microscopy, enzyme morphological methods, light and electron microscopy, enzyme histocytochemistry in light and electron microscope and biochemistry, we have observed the histological structure and ultrastucture of rat kidney as well as the activity and distribution of the index enzymes for the kidney cell membrane such as Mg-adenosine triphosphatase, 5′-nucleotidase, alkaline phosphatase and glucose-6-phosphatase for kidney cell organelle: endoplasmic reticulum. Futhermore, the biochemical quantitation has been given. The results show that there is no toxic damage to the histological structure and enzyme activity and distribution of rat kidney by administration of SVATE-3 in the low dose. But in high dose, the filter membrane of the kidney was damaged and the activity of Mg-ATPase were decreased. This suggests that we should pay more attention to SVATE-3′s toxicological threshold value when using it and get safe treatment.</description><identifier>ISSN: 0044-5991</identifier><identifier>EISSN: 1347-5800</identifier><identifier>DOI: 10.1267/ahc.25.175</identifier><identifier>CODEN: ACHCBO</identifier><language>eng</language><publisher>Kyoto: JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY</publisher><subject>Animal poisons toxicology. Antivenoms ; Biological and medical sciences ; Medical sciences ; Toxicology</subject><ispartof>ACTA HISTOCHEMICA ET CYTOCHEMICA, 1992, Vol.25(1-2), pp.175-179</ispartof><rights>the Japan Society of Histochemistry and Cytochemistry</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5610105$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>SHI, YU XIU</creatorcontrib><creatorcontrib>LIU, Li</creatorcontrib><creatorcontrib>HE, WEI</creatorcontrib><creatorcontrib>ZHU, SHU WEN</creatorcontrib><creatorcontrib>QI, WAN QIANG</creatorcontrib><creatorcontrib>GAO, JUN FENG</creatorcontrib><creatorcontrib>LIU, DONG JAN</creatorcontrib><creatorcontrib>WANG, ZHAN YOU</creatorcontrib><creatorcontrib>XU, YAN PING</creatorcontrib><creatorcontrib>GUO, YU KUEN</creatorcontrib><creatorcontrib>HAO, WEN XEU</creatorcontrib><title>EXPERIMENTAL STUDY FOR THE TOXICOLOGICAL EFFECTS OF SVATE-3 ON RAT KIDNEY-OBSERVATION BY LIGHT AND ELECTRON MICROSCOPE AND BY ENZYME HISTOCYTOCHEMISTRY</title><title>ACTA HISTOCHEMICA ET CYTOCHEMICA</title><addtitle>Acta Histochem. Cytochem.</addtitle><description>We have done an acute toxicological experiment on the rat kidney by administration of SVATE-3 in clinical dose (high and low dose, respectively) for 3 weeks. By using morphological methods, light and electron microscopy, enzyme morphological methods, light and electron microscopy, enzyme histocytochemistry in light and electron microscope and biochemistry, we have observed the histological structure and ultrastucture of rat kidney as well as the activity and distribution of the index enzymes for the kidney cell membrane such as Mg-adenosine triphosphatase, 5′-nucleotidase, alkaline phosphatase and glucose-6-phosphatase for kidney cell organelle: endoplasmic reticulum. Futhermore, the biochemical quantitation has been given. The results show that there is no toxic damage to the histological structure and enzyme activity and distribution of rat kidney by administration of SVATE-3 in the low dose. But in high dose, the filter membrane of the kidney was damaged and the activity of Mg-ATPase were decreased. This suggests that we should pay more attention to SVATE-3′s toxicological threshold value when using it and get safe treatment.</description><subject>Animal poisons toxicology. Antivenoms</subject><subject>Biological and medical sciences</subject><subject>Medical sciences</subject><subject>Toxicology</subject><issn>0044-5991</issn><issn>1347-5800</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><recordid>eNo9kMtOwzAURC0EEuWx4Qu8YIWU4mceyzZ1mog0RomLGjaR6yS0qJQq6YYv4XdxKXRhXWvm3LE1ANxhNMTE9R71ygwJH2KPn4EBpsxzuI_QORggxJjDgwBfgqu-f0cIW50NwLdYPIs8mYlMjVJYqPmkhJHMoYoFVHKRhDKV0yS0nogiEaoCyggWLyMlHAplBvORgk_JJBOlI8eFyK2TWHlcwjSZxgqOsgkUqV3MrTpLwlwWoXwWv7qFRPZazgSMk0LJsLQnFjN7z8sbcNHqTd_c_s1rMI-ECmPn7zuOYb67d8iyDTBzqV_XXt0QN2h5QJgftC11l4xpbmqsa-5zVPMlJYyT2ud0GXgENS01Nb0GD8dc0332fde01a5bf-juq8KoOlRa2UorwitbqYXvj_BO90Zv2k5vzbo_bXAXI4wO2PSIvfd7_dacfN3t12bTHBJx4Pq_qRX5H_aBE2FWuquaLf0BG9GDgg</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>SHI, YU XIU</creator><creator>LIU, Li</creator><creator>HE, WEI</creator><creator>ZHU, SHU WEN</creator><creator>QI, WAN QIANG</creator><creator>GAO, JUN FENG</creator><creator>LIU, DONG JAN</creator><creator>WANG, ZHAN YOU</creator><creator>XU, YAN PING</creator><creator>GUO, YU KUEN</creator><creator>HAO, WEN XEU</creator><general>JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY</general><general>Japan Society of Histochemistry and Cytochemistry</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1992</creationdate><title>EXPERIMENTAL STUDY FOR THE TOXICOLOGICAL EFFECTS OF SVATE-3 ON RAT KIDNEY-OBSERVATION BY LIGHT AND ELECTRON MICROSCOPE AND BY ENZYME HISTOCYTOCHEMISTRY</title><author>SHI, YU XIU ; LIU, Li ; HE, WEI ; ZHU, SHU WEN ; QI, WAN QIANG ; GAO, JUN FENG ; LIU, DONG JAN ; WANG, ZHAN YOU ; XU, YAN PING ; GUO, YU KUEN ; HAO, WEN XEU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-2bf914638dd7de269f592489ff36b44a5cd1ad5850d5b32452d853b9720ef3cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animal poisons toxicology. 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Cytochem.</addtitle><date>1992</date><risdate>1992</risdate><volume>25</volume><issue>1-2</issue><spage>175</spage><epage>179</epage><pages>175-179</pages><issn>0044-5991</issn><eissn>1347-5800</eissn><coden>ACHCBO</coden><abstract>We have done an acute toxicological experiment on the rat kidney by administration of SVATE-3 in clinical dose (high and low dose, respectively) for 3 weeks. By using morphological methods, light and electron microscopy, enzyme morphological methods, light and electron microscopy, enzyme histocytochemistry in light and electron microscope and biochemistry, we have observed the histological structure and ultrastucture of rat kidney as well as the activity and distribution of the index enzymes for the kidney cell membrane such as Mg-adenosine triphosphatase, 5′-nucleotidase, alkaline phosphatase and glucose-6-phosphatase for kidney cell organelle: endoplasmic reticulum. Futhermore, the biochemical quantitation has been given. The results show that there is no toxic damage to the histological structure and enzyme activity and distribution of rat kidney by administration of SVATE-3 in the low dose. But in high dose, the filter membrane of the kidney was damaged and the activity of Mg-ATPase were decreased. This suggests that we should pay more attention to SVATE-3′s toxicological threshold value when using it and get safe treatment.</abstract><cop>Kyoto</cop><pub>JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY</pub><doi>10.1267/ahc.25.175</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | Freely Accessible Japanese Titles (ERDB Project); J-STAGE (Free - Japanese); Full-Text Journals in Chemistry (Open access); EZB Electronic Journals Library |
| subjects | Animal poisons toxicology. Antivenoms Biological and medical sciences Medical sciences Toxicology |
| title | EXPERIMENTAL STUDY FOR THE TOXICOLOGICAL EFFECTS OF SVATE-3 ON RAT KIDNEY-OBSERVATION BY LIGHT AND ELECTRON MICROSCOPE AND BY ENZYME HISTOCYTOCHEMISTRY |
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