Effects of exposure to genistein during pubertal development on the reproductive system of male mice
Genistein, a soybean-originated isoflavone, is widely consumed by humans for putative beneficial health effects but its estrogenic activity may affect adversely the development of the male reproductive system. Twenty-one days old ICR mice weaned from dams fed with a casein-based AIN-76A diet during...
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| Veröffentlicht in: | Journal of Reproduction and Development 2004, Vol.50(4), pp.399-409 |
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| creator | Lee, B.J. (Chungbuk National Univ., Cheongju (Korea R.)) Jung, E.Y Yun, Y.W Kang, J.K Baek, I.J Yon, J.M Lee, Y.B Sohn, H.S Lee, J.Y Kim, K.S Nam, S.Y |
| description | Genistein, a soybean-originated isoflavone, is widely consumed by humans for putative beneficial health effects but its estrogenic activity may affect adversely the development of the male reproductive system. Twenty-one days old ICR mice weaned from dams fed with a casein-based AIN-76A diet during gestation and lactation were exposed to genistein (2.5 and 5.0 mg/kg/day, p.o.) for 5 weeks. 17beta-Estradiol (7.5 micro g/kg/day) and corn oil were used for the positive and negative vehicle controls, respectively. The animals were fed the casein-based AIN-76A diet throughout the experiment. There were no significant differences in body weights of mice between the genistein groups and the negative control group. No significant differences in relative reproductive organ weights were found among all experimental groups. Sperm counts in epididymis and testes were slightly decreased in the genistein-exposed groups compared with control group. Sperm motile characteristics in genistein-exposed groups were slightly higher than those of the control group. Levels of phospholipid hydroxide glutathione peroxidase mRNA in the testis, epididymis, and prostate of mice exposed to genistein or estradiol were significantly higher than those of the controls (P |
| doi_str_mv | 10.1262/jrd.50.399 |
| format | Article |
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(Chungbuk National Univ., Cheongju (Korea R.)) ; Jung, E.Y ; Yun, Y.W ; Kang, J.K ; Baek, I.J ; Yon, J.M ; Lee, Y.B ; Sohn, H.S ; Lee, J.Y ; Kim, K.S ; Nam, S.Y</creator><creatorcontrib>Lee, B.J. (Chungbuk National Univ., Cheongju (Korea R.)) ; Jung, E.Y ; Yun, Y.W ; Kang, J.K ; Baek, I.J ; Yon, J.M ; Lee, Y.B ; Sohn, H.S ; Lee, J.Y ; Kim, K.S ; Nam, S.Y</creatorcontrib><description>Genistein, a soybean-originated isoflavone, is widely consumed by humans for putative beneficial health effects but its estrogenic activity may affect adversely the development of the male reproductive system. Twenty-one days old ICR mice weaned from dams fed with a casein-based AIN-76A diet during gestation and lactation were exposed to genistein (2.5 and 5.0 mg/kg/day, p.o.) for 5 weeks. 17beta-Estradiol (7.5 micro g/kg/day) and corn oil were used for the positive and negative vehicle controls, respectively. The animals were fed the casein-based AIN-76A diet throughout the experiment. There were no significant differences in body weights of mice between the genistein groups and the negative control group. No significant differences in relative reproductive organ weights were found among all experimental groups. Sperm counts in epididymis and testes were slightly decreased in the genistein-exposed groups compared with control group. Sperm motile characteristics in genistein-exposed groups were slightly higher than those of the control group. Levels of phospholipid hydroxide glutathione peroxidase mRNA in the testis, epididymis, and prostate of mice exposed to genistein or estradiol were significantly higher than those of the controls (P<0.05). Exposure to genistein caused hyperplasia of Leydig cells in the testis and a slight increase of interstitial fibroblasts in the epididymis, while estradiol treatment caused severe damage to the testis and epididymis. These results suggest that dietary uptake of genistein during the juvenile period may affect male reproductive development, resulting in a slight decrease in sperm count, but with an increase in sperm motion quality.</description><identifier>ISSN: 0916-8818</identifier><identifier>EISSN: 1348-4400</identifier><identifier>DOI: 10.1262/jrd.50.399</identifier><identifier>PMID: 15329471</identifier><language>eng</language><publisher>Japan: THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT</publisher><subject>Animals ; Anticarcinogenic Agents - toxicity ; Body Weight ; Epididymis - drug effects ; Epididymis - pathology ; Estradiol ; Estradiol - pharmacology ; GENISTEIN ; Genistein - toxicity ; GLUTATHIONE PEROXIDASE ; Glutathione Peroxidase - genetics ; Hyperplasia ; Leydig Cells - drug effects ; Leydig Cells - pathology ; Male ; MALE GENITAL SYSTEM ; MALES ; MICE ; Mice, Inbred ICR ; OESTROGENS ; Organ Size ; Phospholipid hydroxide glutathione peroxidase ; Reproductive toxicity ; RNA, Messenger - analysis ; Seminiferous Epithelium - drug effects ; Seminiferous Epithelium - pathology ; Sexual Maturation ; Sperm ; Sperm Count ; Sperm Motility - drug effects ; SPERMATOZOA</subject><ispartof>Journal of Reproduction and Development, 2004, Vol.50(4), pp.399-409</ispartof><rights>2004 Society for Reproduction and Development</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-62dac9709c9e5219ecaf4546d1ea659898b9a6d1b56782dd00641da14cc0cd613</citedby><cites>FETCH-LOGICAL-c505t-62dac9709c9e5219ecaf4546d1ea659898b9a6d1b56782dd00641da14cc0cd613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15329471$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, B.J. (Chungbuk National Univ., Cheongju (Korea R.))</creatorcontrib><creatorcontrib>Jung, E.Y</creatorcontrib><creatorcontrib>Yun, Y.W</creatorcontrib><creatorcontrib>Kang, J.K</creatorcontrib><creatorcontrib>Baek, I.J</creatorcontrib><creatorcontrib>Yon, J.M</creatorcontrib><creatorcontrib>Lee, Y.B</creatorcontrib><creatorcontrib>Sohn, H.S</creatorcontrib><creatorcontrib>Lee, J.Y</creatorcontrib><creatorcontrib>Kim, K.S</creatorcontrib><creatorcontrib>Nam, S.Y</creatorcontrib><title>Effects of exposure to genistein during pubertal development on the reproductive system of male mice</title><title>Journal of Reproduction and Development</title><addtitle>J. Reprod. Dev.</addtitle><description>Genistein, a soybean-originated isoflavone, is widely consumed by humans for putative beneficial health effects but its estrogenic activity may affect adversely the development of the male reproductive system. Twenty-one days old ICR mice weaned from dams fed with a casein-based AIN-76A diet during gestation and lactation were exposed to genistein (2.5 and 5.0 mg/kg/day, p.o.) for 5 weeks. 17beta-Estradiol (7.5 micro g/kg/day) and corn oil were used for the positive and negative vehicle controls, respectively. The animals were fed the casein-based AIN-76A diet throughout the experiment. There were no significant differences in body weights of mice between the genistein groups and the negative control group. No significant differences in relative reproductive organ weights were found among all experimental groups. Sperm counts in epididymis and testes were slightly decreased in the genistein-exposed groups compared with control group. Sperm motile characteristics in genistein-exposed groups were slightly higher than those of the control group. Levels of phospholipid hydroxide glutathione peroxidase mRNA in the testis, epididymis, and prostate of mice exposed to genistein or estradiol were significantly higher than those of the controls (P<0.05). Exposure to genistein caused hyperplasia of Leydig cells in the testis and a slight increase of interstitial fibroblasts in the epididymis, while estradiol treatment caused severe damage to the testis and epididymis. These results suggest that dietary uptake of genistein during the juvenile period may affect male reproductive development, resulting in a slight decrease in sperm count, but with an increase in sperm motion quality.</description><subject>Animals</subject><subject>Anticarcinogenic Agents - toxicity</subject><subject>Body Weight</subject><subject>Epididymis - drug effects</subject><subject>Epididymis - pathology</subject><subject>Estradiol</subject><subject>Estradiol - pharmacology</subject><subject>GENISTEIN</subject><subject>Genistein - toxicity</subject><subject>GLUTATHIONE PEROXIDASE</subject><subject>Glutathione Peroxidase - genetics</subject><subject>Hyperplasia</subject><subject>Leydig Cells - drug effects</subject><subject>Leydig Cells - pathology</subject><subject>Male</subject><subject>MALE GENITAL SYSTEM</subject><subject>MALES</subject><subject>MICE</subject><subject>Mice, Inbred ICR</subject><subject>OESTROGENS</subject><subject>Organ Size</subject><subject>Phospholipid hydroxide glutathione peroxidase</subject><subject>Reproductive toxicity</subject><subject>RNA, Messenger - analysis</subject><subject>Seminiferous Epithelium - drug effects</subject><subject>Seminiferous Epithelium - pathology</subject><subject>Sexual Maturation</subject><subject>Sperm</subject><subject>Sperm Count</subject><subject>Sperm Motility - drug effects</subject><subject>SPERMATOZOA</subject><issn>0916-8818</issn><issn>1348-4400</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkElLBDEQRoMoOi4X70rOQo-VdJLpnETEFUEPeg6ZpHrsoTeSjOi_N9IulyqKevWgPkKOGcwZV_x8HfxcwrzUeovMWCmqQgiAbTIDzVRRVazaI_sxrgFKLpXYJXtMllyLBZsRf13X6FKkQ03xYxziJiBNA11h38SETU_9JjT9io6bJYZkW-rxHdth7LBPdOhpekMacAyD37jUvCONn_mu-_Z1tkXaNQ4PyU5t24hHP_2AvN5cv1zdFY9Pt_dXl4-FkyBTobi3Ti9AO42SM43O1kIK5RlaJXWlq6W2eVpKtai49wBKMG-ZcA6cV6w8IGeT14UhxoC1GUPT2fBpGJjvqEyOykgwOaoMn05w_qxD_4_-ZJOBiwlYx2RX-AfYkBrX4q9LTCUr_zbuzQaDfTacTIbaDsauQhPNwzMHkACskrz8AsqwhfQ</recordid><startdate>20040801</startdate><enddate>20040801</enddate><creator>Lee, B.J. (Chungbuk National Univ., Cheongju (Korea R.))</creator><creator>Jung, E.Y</creator><creator>Yun, Y.W</creator><creator>Kang, J.K</creator><creator>Baek, I.J</creator><creator>Yon, J.M</creator><creator>Lee, Y.B</creator><creator>Sohn, H.S</creator><creator>Lee, J.Y</creator><creator>Kim, K.S</creator><creator>Nam, S.Y</creator><general>THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20040801</creationdate><title>Effects of exposure to genistein during pubertal development on the reproductive system of male mice</title><author>Lee, B.J. (Chungbuk National Univ., Cheongju (Korea R.)) ; Jung, E.Y ; Yun, Y.W ; Kang, J.K ; Baek, I.J ; Yon, J.M ; Lee, Y.B ; Sohn, H.S ; Lee, J.Y ; Kim, K.S ; Nam, S.Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-62dac9709c9e5219ecaf4546d1ea659898b9a6d1b56782dd00641da14cc0cd613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Anticarcinogenic Agents - toxicity</topic><topic>Body Weight</topic><topic>Epididymis - drug effects</topic><topic>Epididymis - pathology</topic><topic>Estradiol</topic><topic>Estradiol - pharmacology</topic><topic>GENISTEIN</topic><topic>Genistein - toxicity</topic><topic>GLUTATHIONE PEROXIDASE</topic><topic>Glutathione Peroxidase - genetics</topic><topic>Hyperplasia</topic><topic>Leydig Cells - drug effects</topic><topic>Leydig Cells - pathology</topic><topic>Male</topic><topic>MALE GENITAL SYSTEM</topic><topic>MALES</topic><topic>MICE</topic><topic>Mice, Inbred ICR</topic><topic>OESTROGENS</topic><topic>Organ Size</topic><topic>Phospholipid hydroxide glutathione peroxidase</topic><topic>Reproductive toxicity</topic><topic>RNA, Messenger - analysis</topic><topic>Seminiferous Epithelium - drug effects</topic><topic>Seminiferous Epithelium - pathology</topic><topic>Sexual Maturation</topic><topic>Sperm</topic><topic>Sperm Count</topic><topic>Sperm Motility - drug effects</topic><topic>SPERMATOZOA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, B.J. (Chungbuk National Univ., Cheongju (Korea R.))</creatorcontrib><creatorcontrib>Jung, E.Y</creatorcontrib><creatorcontrib>Yun, Y.W</creatorcontrib><creatorcontrib>Kang, J.K</creatorcontrib><creatorcontrib>Baek, I.J</creatorcontrib><creatorcontrib>Yon, J.M</creatorcontrib><creatorcontrib>Lee, Y.B</creatorcontrib><creatorcontrib>Sohn, H.S</creatorcontrib><creatorcontrib>Lee, J.Y</creatorcontrib><creatorcontrib>Kim, K.S</creatorcontrib><creatorcontrib>Nam, S.Y</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of Reproduction and Development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, B.J. (Chungbuk National Univ., Cheongju (Korea R.))</au><au>Jung, E.Y</au><au>Yun, Y.W</au><au>Kang, J.K</au><au>Baek, I.J</au><au>Yon, J.M</au><au>Lee, Y.B</au><au>Sohn, H.S</au><au>Lee, J.Y</au><au>Kim, K.S</au><au>Nam, S.Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of exposure to genistein during pubertal development on the reproductive system of male mice</atitle><jtitle>Journal of Reproduction and Development</jtitle><addtitle>J. Reprod. Dev.</addtitle><date>2004-08-01</date><risdate>2004</risdate><volume>50</volume><issue>4</issue><spage>399</spage><epage>409</epage><pages>399-409</pages><issn>0916-8818</issn><eissn>1348-4400</eissn><abstract>Genistein, a soybean-originated isoflavone, is widely consumed by humans for putative beneficial health effects but its estrogenic activity may affect adversely the development of the male reproductive system. Twenty-one days old ICR mice weaned from dams fed with a casein-based AIN-76A diet during gestation and lactation were exposed to genistein (2.5 and 5.0 mg/kg/day, p.o.) for 5 weeks. 17beta-Estradiol (7.5 micro g/kg/day) and corn oil were used for the positive and negative vehicle controls, respectively. The animals were fed the casein-based AIN-76A diet throughout the experiment. There were no significant differences in body weights of mice between the genistein groups and the negative control group. No significant differences in relative reproductive organ weights were found among all experimental groups. Sperm counts in epididymis and testes were slightly decreased in the genistein-exposed groups compared with control group. Sperm motile characteristics in genistein-exposed groups were slightly higher than those of the control group. Levels of phospholipid hydroxide glutathione peroxidase mRNA in the testis, epididymis, and prostate of mice exposed to genistein or estradiol were significantly higher than those of the controls (P<0.05). Exposure to genistein caused hyperplasia of Leydig cells in the testis and a slight increase of interstitial fibroblasts in the epididymis, while estradiol treatment caused severe damage to the testis and epididymis. These results suggest that dietary uptake of genistein during the juvenile period may affect male reproductive development, resulting in a slight decrease in sperm count, but with an increase in sperm motion quality.</abstract><cop>Japan</cop><pub>THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT</pub><pmid>15329471</pmid><doi>10.1262/jrd.50.399</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Anticarcinogenic Agents - toxicity Body Weight Epididymis - drug effects Epididymis - pathology Estradiol Estradiol - pharmacology GENISTEIN Genistein - toxicity GLUTATHIONE PEROXIDASE Glutathione Peroxidase - genetics Hyperplasia Leydig Cells - drug effects Leydig Cells - pathology Male MALE GENITAL SYSTEM MALES MICE Mice, Inbred ICR OESTROGENS Organ Size Phospholipid hydroxide glutathione peroxidase Reproductive toxicity RNA, Messenger - analysis Seminiferous Epithelium - drug effects Seminiferous Epithelium - pathology Sexual Maturation Sperm Sperm Count Sperm Motility - drug effects SPERMATOZOA |
| title | Effects of exposure to genistein during pubertal development on the reproductive system of male mice |
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