Epigenetically Immature Oocytes Lead to Loss of Imprinting During Embryogenesis

Loss of imprinting (LOI) is occasionally observed in human imprinting disorders. However, the process behind the LOI is not fully understood. To gain a better understanding, we produced embryos and pups from mouse oocytes that lacked a complete methylation imprint using a method that involved transf...

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Veröffentlicht in:	Journal of Reproduction and Development 2011, Vol.57(3), pp.327-334
Hauptverfasser:	OBATA, Yayoi, HIURA, Hitoshi, FUKUDA, Atsushi, KOMIYAMA, Junichi, HATADA, Izuho, KONO, Tomohiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA methylation DNA Methylation - genetics Embryonic Development - genetics Female Fertilization in Vitro Gene expression Gene Expression Profiling Genetic Loci Genomic Imprinting Growing oocyte Insulin-Like Growth Factor II - genetics KCNQ1 Potassium Channel - genetics Loss of imprinting (LOI) Mice Mosaicism Obesity - genetics Oocytes - metabolism Proteins - genetics snRNP Core Proteins - genetics
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