The effect of haemolysis on certain canine serum chemistry parameters
Haemolysis has been known to cause artefacts in certain canine serum chemistry parameters. These parameters are often used by researchers to detect toxicity in certain studies; haemolysis, therefore, can make serum chemistry interpretation very difficult. In order to determine whether a relationship...
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| Veröffentlicht in: | Laboratory animals (London) 1990-01, Vol.24 (1), p.32-35 |
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| creator | Leard, B L Alsaker, R D Porter, W P Sobel, L P |
| description | Haemolysis has been known to cause artefacts in certain canine serum chemistry parameters. These parameters are often used by researchers to detect toxicity in certain studies; haemolysis, therefore, can make serum chemistry interpretation very difficult. In order to determine whether a relationship existed between the level of haemolysis and certain canine serum chemistry parameters, haemolysis was artificially induced by adding a haemolysate of known haemoglobin concentration to serum specimens. A routine clinical chemistry profile was performed on each specimen. Statistical analyses were performed on the results to examine the relationship between level of haemolysis and serum chemistry results. Interpretation of serum chemistry results of haemolysed canine sera paralleled, in most cases, human historical data. |
| doi_str_mv | 10.1258/002367790780890239 |
| format | Article |
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These parameters are often used by researchers to detect toxicity in certain studies; haemolysis, therefore, can make serum chemistry interpretation very difficult. In order to determine whether a relationship existed between the level of haemolysis and certain canine serum chemistry parameters, haemolysis was artificially induced by adding a haemolysate of known haemoglobin concentration to serum specimens. A routine clinical chemistry profile was performed on each specimen. Statistical analyses were performed on the results to examine the relationship between level of haemolysis and serum chemistry results. 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These parameters are often used by researchers to detect toxicity in certain studies; haemolysis, therefore, can make serum chemistry interpretation very difficult. In order to determine whether a relationship existed between the level of haemolysis and certain canine serum chemistry parameters, haemolysis was artificially induced by adding a haemolysate of known haemoglobin concentration to serum specimens. A routine clinical chemistry profile was performed on each specimen. Statistical analyses were performed on the results to examine the relationship between level of haemolysis and serum chemistry results. Interpretation of serum chemistry results of haemolysed canine sera paralleled, in most cases, human historical data.</description><subject>Animals</subject><subject>Blood Chemical Analysis</subject><subject>Dogs - physiology</subject><subject>Female</subject><subject>Hemoglobins - physiology</subject><subject>Hemolysis</subject><subject>Male</subject><issn>0023-6772</issn><issn>1758-1117</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UEtqwzAUFKUlTdNeoFDQBdzoyXYkLUtIPxDoJl2bJ_mpcYjtIDkL374KCd0UuhqG-cAMY48gnkGWei6EzBdKGaG00CYRc8WmoEqdAYC6ZtOTIUsOecvuYtwlCoUWEzaRuShyCVO22myJk_fkBt57vkVq-_0Ym8j7jjsKAzYJsWs64pHCseVuS20ThzDyAwZsaaAQ79mNx32khwvO2NfrarN8z9afbx_Ll3XmpFEms1CWmmowTiBqA2ByIkCvCQqDypI3pS2tlEXtTY2Lwhq7yIV1JCRaj_mMyXOvC32MgXx1CE2LYaxAVKdLqr-XpNDTOXQ42pbq38jlg6TPz3rEb6p2_TF0acN_jT9FY2oK</recordid><startdate>19900101</startdate><enddate>19900101</enddate><creator>Leard, B L</creator><creator>Alsaker, R D</creator><creator>Porter, W P</creator><creator>Sobel, L P</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19900101</creationdate><title>The effect of haemolysis on certain canine serum chemistry parameters</title><author>Leard, B L ; Alsaker, R D ; Porter, W P ; Sobel, L P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2979-b1558ed19c0aa891193ee1af8e149a7bef95b5b224df9da64b9b630bce02abfa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Blood Chemical Analysis</topic><topic>Dogs - physiology</topic><topic>Female</topic><topic>Hemoglobins - physiology</topic><topic>Hemolysis</topic><topic>Male</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leard, B L</creatorcontrib><creatorcontrib>Alsaker, R D</creatorcontrib><creatorcontrib>Porter, W P</creatorcontrib><creatorcontrib>Sobel, L P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Laboratory animals (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leard, B L</au><au>Alsaker, R D</au><au>Porter, W P</au><au>Sobel, L P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of haemolysis on certain canine serum chemistry parameters</atitle><jtitle>Laboratory animals (London)</jtitle><addtitle>Lab Anim</addtitle><date>1990-01-01</date><risdate>1990</risdate><volume>24</volume><issue>1</issue><spage>32</spage><epage>35</epage><pages>32-35</pages><issn>0023-6772</issn><eissn>1758-1117</eissn><abstract>Haemolysis has been known to cause artefacts in certain canine serum chemistry parameters. 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| ispartof | Laboratory animals (London), 1990-01, Vol.24 (1), p.32-35 |
| issn | 0023-6772 1758-1117 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Blood Chemical Analysis Dogs - physiology Female Hemoglobins - physiology Hemolysis Male |
| title | The effect of haemolysis on certain canine serum chemistry parameters |
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