Ammonia build-up in animal boxes and its effect on rat tracheal epithelium
Some common laboratory species are now considered unsuitable for the study of the toxicity of inhalants because of the natural incidence of abnormal respiratory histology. Levels of ammonia commonly encountered in animal boxes and cages have been shown to cause histopathological changes in the trach...
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| Veröffentlicht in: | Laboratory animals (London) 1976-04, Vol.10 (2), p.93-104 |
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| creator | Gamble, M R Clough, G |
| description | Some common laboratory species are now considered unsuitable for the study of the toxicity of inhalants because of the natural incidence of abnormal respiratory histology. Levels of ammonia commonly encountered in animal boxes and cages have been shown to cause histopathological changes in the tracheal epithelium of rats, and it is suggested that 'abnormal respiratory histology' could be a reflection of the standard of husbandry employed before and during an experiment. |
| doi_str_mv | 10.1258/002367776781071477 |
| format | Article |
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Levels of ammonia commonly encountered in animal boxes and cages have been shown to cause histopathological changes in the tracheal epithelium of rats, and it is suggested that 'abnormal respiratory histology' could be a reflection of the standard of husbandry employed before and during an experiment.</description><identifier>ISSN: 0023-6772</identifier><identifier>EISSN: 1758-1117</identifier><identifier>DOI: 10.1258/002367776781071477</identifier><identifier>PMID: 933464</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Ammonia - analysis ; Ammonia - pharmacology ; Animals ; Cricetinae ; Epithelium - drug effects ; Female ; Guinea Pigs ; Housing, Animal ; Humidity ; Male ; Mice ; Rabbits ; Rats ; Trachea - drug effects</subject><ispartof>Laboratory animals (London), 1976-04, Vol.10 (2), p.93-104</ispartof><rights>1976 Royal Society of Medicine Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3917-7bb8e2f978adf560bd1fef01671a6e8586f1ed525b4c563bcdd0044a7927a15d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/933464$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gamble, M R</creatorcontrib><creatorcontrib>Clough, G</creatorcontrib><title>Ammonia build-up in animal boxes and its effect on rat tracheal epithelium</title><title>Laboratory animals (London)</title><addtitle>Lab Anim</addtitle><description>Some common laboratory species are now considered unsuitable for the study of the toxicity of inhalants because of the natural incidence of abnormal respiratory histology. Levels of ammonia commonly encountered in animal boxes and cages have been shown to cause histopathological changes in the tracheal epithelium of rats, and it is suggested that 'abnormal respiratory histology' could be a reflection of the standard of husbandry employed before and during an experiment.</description><subject>Ammonia - analysis</subject><subject>Ammonia - pharmacology</subject><subject>Animals</subject><subject>Cricetinae</subject><subject>Epithelium - drug effects</subject><subject>Female</subject><subject>Guinea Pigs</subject><subject>Housing, Animal</subject><subject>Humidity</subject><subject>Male</subject><subject>Mice</subject><subject>Rabbits</subject><subject>Rats</subject><subject>Trachea - drug effects</subject><issn>0023-6772</issn><issn>1758-1117</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UMtKxDAUDeJrHP0BcZEfqJPbNrnpchgcHwy40XVJmsTp0BdJC_r3Zqi4EVxdDufBPYeQW2D3kHK5YizNBCIKlMAQcsQTsgDkMgEAPCWLoyCJivSSXIVwiBByyS7IeZFlucgX5GXdtn1XK6qnujHJNNC6o6qrW9VQ3X_aEIGh9Riodc5WI-076tVIR6-qvY0iO9Tj3jb11F6TM6eaYG9-7pK8bx_eNk_J7vXxebPeJVVWACaotbSpK1Aq47hg2oCzjoFAUMJKLoUDa3jKdV5xkenKGMbyXGGRogJusiVJ59zK9yF468rBx3_9VwmsPM5S_p0lmu5m0zDp1ppfy7xDpFczHdSHLQ_95LtY4b_AbwiGaiI</recordid><startdate>19760401</startdate><enddate>19760401</enddate><creator>Gamble, M R</creator><creator>Clough, G</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19760401</creationdate><title>Ammonia build-up in animal boxes and its effect on rat tracheal epithelium</title><author>Gamble, M R ; Clough, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3917-7bb8e2f978adf560bd1fef01671a6e8586f1ed525b4c563bcdd0044a7927a15d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Ammonia - analysis</topic><topic>Ammonia - pharmacology</topic><topic>Animals</topic><topic>Cricetinae</topic><topic>Epithelium - drug effects</topic><topic>Female</topic><topic>Guinea Pigs</topic><topic>Housing, Animal</topic><topic>Humidity</topic><topic>Male</topic><topic>Mice</topic><topic>Rabbits</topic><topic>Rats</topic><topic>Trachea - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gamble, M R</creatorcontrib><creatorcontrib>Clough, G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Laboratory animals (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gamble, M R</au><au>Clough, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ammonia build-up in animal boxes and its effect on rat tracheal epithelium</atitle><jtitle>Laboratory animals (London)</jtitle><addtitle>Lab Anim</addtitle><date>1976-04-01</date><risdate>1976</risdate><volume>10</volume><issue>2</issue><spage>93</spage><epage>104</epage><pages>93-104</pages><issn>0023-6772</issn><eissn>1758-1117</eissn><abstract>Some common laboratory species are now considered unsuitable for the study of the toxicity of inhalants because of the natural incidence of abnormal respiratory histology. 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| ispartof | Laboratory animals (London), 1976-04, Vol.10 (2), p.93-104 |
| issn | 0023-6772 1758-1117 |
| language | eng |
| recordid | cdi_crossref_primary_10_1258_002367776781071477 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Ammonia - analysis Ammonia - pharmacology Animals Cricetinae Epithelium - drug effects Female Guinea Pigs Housing, Animal Humidity Male Mice Rabbits Rats Trachea - drug effects |
| title | Ammonia build-up in animal boxes and its effect on rat tracheal epithelium |
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