Studies on the Efficacy of Diethyxime as an Antidote against Organophosphorus Intoxication in Rats
Diethyxime, a non-quaternarv Cholinesterase reactivator was evaluated for its antidotal efficacy against organophosphorus intoxication in rats using the protection index. Cholinesterase reactivation and neuromuscular function as the experimental protocol. Diethyxime along with atropine produced a ma...
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| Veröffentlicht in: | Japanese Journal of Pharmacology 1986, Vol.41(3), pp.267-271 |
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| container_title | Japanese Journal of Pharmacology |
| container_volume | 41 |
| creator | DUBE, S.N. GHOSH, A.K. JEEVARATHINAM, K. KUMAR, D. GUPTA, S. DAS PANT, B.P. BATRA, B.S. JAISWAL, D.K. |
| description | Diethyxime, a non-quaternarv Cholinesterase reactivator was evaluated for its antidotal efficacy against organophosphorus intoxication in rats using the protection index. Cholinesterase reactivation and neuromuscular function as the experimental protocol. Diethyxime along with atropine produced a marked antidotal effect against dimethyl dichlorovinyl phosphate (DDVP) poisoning on all the parameters studied. The action of diethyxime was mainly peripheral. The protective efficacy against diisopropyl fluorophosphnte (DFP) poisoning was not observed with this reactivator. |
| doi_str_mv | 10.1254/jjp.41.267 |
| format | Article |
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The protective efficacy against diisopropyl fluorophosphnte (DFP) poisoning was not observed with this reactivator.</description><identifier>ISSN: 0021-5198</identifier><identifier>EISSN: 1347-3506</identifier><identifier>DOI: 10.1254/jjp.41.267</identifier><identifier>PMID: 3761745</identifier><identifier>CODEN: JJPAAZ</identifier><language>eng</language><publisher>Kyoto: The Japanese Pharmacological Society</publisher><subject>Animals ; Antidotes ; Atropine - pharmacology ; Biological and medical sciences ; Bradycardia - chemically induced ; Cholinesterase Reactivators - therapeutic use ; Cholinesterases - blood ; Dichlorvos - antagonists & inhibitors ; Isoflurophate - antagonists & inhibitors ; Medical sciences ; Neuromuscular Diseases - chemically induced ; Oximes - therapeutic use ; Pesticides, fertilizers and other agrochemicals toxicology ; Rats ; Toxicology</subject><ispartof>The Japanese Journal of Pharmacology, 1986, Vol.41(3), pp.267-271</ispartof><rights>1986 Elsevier B.V.</rights><rights>The Japanese PharmacologicalSociety</rights><rights>1987 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c683t-ca9e0836f12bc47dd50302bd8e9c71e114eedfa336a6ed36187d8c06912c9dc93</citedby><cites>FETCH-LOGICAL-c683t-ca9e0836f12bc47dd50302bd8e9c71e114eedfa336a6ed36187d8c06912c9dc93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8127811$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3761745$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DUBE, S.N.</creatorcontrib><creatorcontrib>GHOSH, A.K.</creatorcontrib><creatorcontrib>JEEVARATHINAM, K.</creatorcontrib><creatorcontrib>KUMAR, D.</creatorcontrib><creatorcontrib>GUPTA, S. DAS</creatorcontrib><creatorcontrib>PANT, B.P.</creatorcontrib><creatorcontrib>BATRA, B.S.</creatorcontrib><creatorcontrib>JAISWAL, D.K.</creatorcontrib><creatorcontrib>Division of Pharmacology</creatorcontrib><creatorcontrib>Division of Synthetic Chemistry</creatorcontrib><creatorcontrib>Defence Research and Development Establishment</creatorcontrib><title>Studies on the Efficacy of Diethyxime as an Antidote against Organophosphorus Intoxication in Rats</title><title>Japanese Journal of Pharmacology</title><addtitle>Jpn.J.Pharmacol.</addtitle><description>Diethyxime, a non-quaternarv Cholinesterase reactivator was evaluated for its antidotal efficacy against organophosphorus intoxication in rats using the protection index. Cholinesterase reactivation and neuromuscular function as the experimental protocol. Diethyxime along with atropine produced a marked antidotal effect against dimethyl dichlorovinyl phosphate (DDVP) poisoning on all the parameters studied. The action of diethyxime was mainly peripheral. The protective efficacy against diisopropyl fluorophosphnte (DFP) poisoning was not observed with this reactivator.</description><subject>Animals</subject><subject>Antidotes</subject><subject>Atropine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Bradycardia - chemically induced</subject><subject>Cholinesterase Reactivators - therapeutic use</subject><subject>Cholinesterases - blood</subject><subject>Dichlorvos - antagonists & inhibitors</subject><subject>Isoflurophate - antagonists & inhibitors</subject><subject>Medical sciences</subject><subject>Neuromuscular Diseases - chemically induced</subject><subject>Oximes - therapeutic use</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>Rats</subject><subject>Toxicology</subject><issn>0021-5198</issn><issn>1347-3506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkU2L2zAQhk1p2abbXnov6NBTwanGkiX7uOxHu7Cw0I-zUCQ5kXEkIyll8-87wWlOPWiGYV6emXlVVR-BrqFp-ddxnNcc1o2Qr6oVMC5r1lLxulpR2kDdQt-9rd7lPGLZUeBX1RWTAiRvV9XmZzlY7zKJgZSdI_fD4I02RxIHcudd2R1f_N4RnYkO5CYUb2PBcqt9yIU8p60Ocd7FjC8dMnkMJb4goHjk-UB-6JLfV28GPWX34Zyvq98P979uv9dPz98eb2-eaiM6Vmqje0c7JgZoNoZLa1vKaLOxneuNBAfAnbODZkxo4SwT0EnbGSp6aExvTc-uqy8L16SYc3KDmpPf63RUQNXJJ4U-KQ4KfULxp0U8HzZ7Zy_SszHY_3zu62z0NCQdjM8XWQeN7ABQ9rDIkIFnTzFMPjg1xkMKeKsygxjHOE8K_0AoSjlQhgkUxSUwSJA9a4Eh6G4BjbnorbsM0ql4MyFx3mXoWzjtz5ZwIvxrm51OygXE8AXj0Og_3iWVjXfB4HbJmaJs9P9z4y9vk7G7</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>DUBE, S.N.</creator><creator>GHOSH, A.K.</creator><creator>JEEVARATHINAM, K.</creator><creator>KUMAR, D.</creator><creator>GUPTA, S. DAS</creator><creator>PANT, B.P.</creator><creator>BATRA, B.S.</creator><creator>JAISWAL, D.K.</creator><general>The Japanese Pharmacological Society</general><general>Japanese Pharmacological Society</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1986</creationdate><title>Studies on the Efficacy of Diethyxime as an Antidote against Organophosphorus Intoxication in Rats</title><author>DUBE, S.N. ; GHOSH, A.K. ; JEEVARATHINAM, K. ; KUMAR, D. ; GUPTA, S. DAS ; PANT, B.P. ; BATRA, B.S. ; JAISWAL, D.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c683t-ca9e0836f12bc47dd50302bd8e9c71e114eedfa336a6ed36187d8c06912c9dc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Antidotes</topic><topic>Atropine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Bradycardia - chemically induced</topic><topic>Cholinesterase Reactivators - therapeutic use</topic><topic>Cholinesterases - blood</topic><topic>Dichlorvos - antagonists & inhibitors</topic><topic>Isoflurophate - antagonists & inhibitors</topic><topic>Medical sciences</topic><topic>Neuromuscular Diseases - chemically induced</topic><topic>Oximes - therapeutic use</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>Rats</topic><topic>Toxicology</topic><toplevel>online_resources</toplevel><creatorcontrib>DUBE, S.N.</creatorcontrib><creatorcontrib>GHOSH, A.K.</creatorcontrib><creatorcontrib>JEEVARATHINAM, K.</creatorcontrib><creatorcontrib>KUMAR, D.</creatorcontrib><creatorcontrib>GUPTA, S. DAS</creatorcontrib><creatorcontrib>PANT, B.P.</creatorcontrib><creatorcontrib>BATRA, B.S.</creatorcontrib><creatorcontrib>JAISWAL, D.K.</creatorcontrib><creatorcontrib>Division of Pharmacology</creatorcontrib><creatorcontrib>Division of Synthetic Chemistry</creatorcontrib><creatorcontrib>Defence Research and Development Establishment</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Japanese Journal of Pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DUBE, S.N.</au><au>GHOSH, A.K.</au><au>JEEVARATHINAM, K.</au><au>KUMAR, D.</au><au>GUPTA, S. DAS</au><au>PANT, B.P.</au><au>BATRA, B.S.</au><au>JAISWAL, D.K.</au><aucorp>Division of Pharmacology</aucorp><aucorp>Division of Synthetic Chemistry</aucorp><aucorp>Defence Research and Development Establishment</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studies on the Efficacy of Diethyxime as an Antidote against Organophosphorus Intoxication in Rats</atitle><jtitle>Japanese Journal of Pharmacology</jtitle><addtitle>Jpn.J.Pharmacol.</addtitle><date>1986</date><risdate>1986</risdate><volume>41</volume><issue>3</issue><spage>267</spage><epage>271</epage><pages>267-271</pages><issn>0021-5198</issn><eissn>1347-3506</eissn><coden>JJPAAZ</coden><abstract>Diethyxime, a non-quaternarv Cholinesterase reactivator was evaluated for its antidotal efficacy against organophosphorus intoxication in rats using the protection index. Cholinesterase reactivation and neuromuscular function as the experimental protocol. Diethyxime along with atropine produced a marked antidotal effect against dimethyl dichlorovinyl phosphate (DDVP) poisoning on all the parameters studied. The action of diethyxime was mainly peripheral. The protective efficacy against diisopropyl fluorophosphnte (DFP) poisoning was not observed with this reactivator.</abstract><cop>Kyoto</cop><pub>The Japanese Pharmacological Society</pub><pmid>3761745</pmid><doi>10.1254/jjp.41.267</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Japanese Journal of Pharmacology, 1986, Vol.41(3), pp.267-271 |
| issn | 0021-5198 1347-3506 |
| language | eng |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Antidotes Atropine - pharmacology Biological and medical sciences Bradycardia - chemically induced Cholinesterase Reactivators - therapeutic use Cholinesterases - blood Dichlorvos - antagonists & inhibitors Isoflurophate - antagonists & inhibitors Medical sciences Neuromuscular Diseases - chemically induced Oximes - therapeutic use Pesticides, fertilizers and other agrochemicals toxicology Rats Toxicology |
| title | Studies on the Efficacy of Diethyxime as an Antidote against Organophosphorus Intoxication in Rats |
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