The Enhancing Effect of Gelatin on Aprotinin Activity
Following preincubation of aprotinin with gelatin, the inhibitory effect on the trypsin activity was enhanced under the same condition as in the case of enhanced antigen-antibody reaction of aprotinin in gel in the presence of gelatin. In the immunochemical titration of aprotinin, gelatin treatment...
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| Veröffentlicht in: | Japanese journal of pharmacology 1984, Vol.36(2), pp.197-203 |
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| container_end_page | 203 |
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| container_issue | 2 |
| container_start_page | 197 |
| container_title | Japanese journal of pharmacology |
| container_volume | 36 |
| creator | SHIKIMI, Tadahiro TANABE, Youko HATTORI, Keisuke |
| description | Following preincubation of aprotinin with gelatin, the inhibitory effect on the trypsin activity was enhanced under the same condition as in the case of enhanced antigen-antibody reaction of aprotinin in gel in the presence of gelatin. In the immunochemical titration of aprotinin, gelatin treatment decreased the value of the equivalence point of aprotinin. Immunoprecipitation of aprotinin pre-incubated with or without gelatin adjusted to equal activity per unit volume resulted in overlapping equivalence points. These data suggest that the increase in aprotinin activity in the presence of gelatin is due to increase in the active form of aprotinin. |
| doi_str_mv | 10.1254/jjp.36.197 |
| format | Article |
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In the immunochemical titration of aprotinin, gelatin treatment decreased the value of the equivalence point of aprotinin. Immunoprecipitation of aprotinin pre-incubated with or without gelatin adjusted to equal activity per unit volume resulted in overlapping equivalence points. These data suggest that the increase in aprotinin activity in the presence of gelatin is due to increase in the active form of aprotinin.</description><identifier>ISSN: 0021-5198</identifier><identifier>EISSN: 1347-3506</identifier><identifier>DOI: 10.1254/jjp.36.197</identifier><identifier>PMID: 6210387</identifier><identifier>CODEN: JJPAAZ</identifier><language>eng</language><publisher>Kyoto: The Japanese Pharmacological Society</publisher><subject>Antigen-Antibody Reactions - drug effects ; Aprotinin - immunology ; Aprotinin - pharmacology ; Biological and medical sciences ; Digestive system ; Gelatin - pharmacology ; Humans ; Immunochemistry ; Immunodiffusion ; Immunoglobulin G - biosynthesis ; Medical sciences ; Pharmacology. 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In the immunochemical titration of aprotinin, gelatin treatment decreased the value of the equivalence point of aprotinin. Immunoprecipitation of aprotinin pre-incubated with or without gelatin adjusted to equal activity per unit volume resulted in overlapping equivalence points. These data suggest that the increase in aprotinin activity in the presence of gelatin is due to increase in the active form of aprotinin.</description><subject>Antigen-Antibody Reactions - drug effects</subject><subject>Aprotinin - immunology</subject><subject>Aprotinin - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Digestive system</subject><subject>Gelatin - pharmacology</subject><subject>Humans</subject><subject>Immunochemistry</subject><subject>Immunodiffusion</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Trypsin - pharmacology</subject><issn>0021-5198</issn><issn>1347-3506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j81LwzAYh4Moc04v3oUePAmdefPZHsecUxh4meeQpMna0nWlqYL_vRkdvbwf_B7elwehR8BLIJy91nW3pGIJubxCc6BMppRjcY3mGBNIOeTZLboLoY5rhoHN0EwQwDSTc8T3pUs2balbW7WHZOO9s0Ny8snWNXqo2uTUJquuP8UxLis7VL_V8HePbrxugnu49AX6ft_s1x_p7mv7uV7tUsukGFLDHRY5lZJYjIEUnAtuvMkto9zQXBjOSUHAa1n4ghEjMiYNFpJAJgqPgS7Qy3jX9qcQeudV11dH3f8pwOqsrqK6okJF9Qg_jXD3Y46umNCLa8yfL7kOVje-PzuHCcsJoyBIxN5GrA6DPrgp1_1Q2capuisD5BzOb8lY4vcptqXulWvpPyZDdyg</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>SHIKIMI, Tadahiro</creator><creator>TANABE, Youko</creator><creator>HATTORI, Keisuke</creator><general>The Japanese Pharmacological Society</general><general>Japanese Pharmacological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19840101</creationdate><title>The Enhancing Effect of Gelatin on Aprotinin Activity</title><author>SHIKIMI, Tadahiro ; TANABE, Youko ; HATTORI, Keisuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-b5e0693772c0012d5565bfb9c435b396b552d21fa7dfd42b6847b0672186df013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Antigen-Antibody Reactions - drug effects</topic><topic>Aprotinin - immunology</topic><topic>Aprotinin - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Digestive system</topic><topic>Gelatin - pharmacology</topic><topic>Humans</topic><topic>Immunochemistry</topic><topic>Immunodiffusion</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Trypsin - pharmacology</topic><toplevel>online_resources</toplevel><creatorcontrib>SHIKIMI, Tadahiro</creatorcontrib><creatorcontrib>TANABE, Youko</creatorcontrib><creatorcontrib>HATTORI, Keisuke</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Japanese journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHIKIMI, Tadahiro</au><au>TANABE, Youko</au><au>HATTORI, Keisuke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Enhancing Effect of Gelatin on Aprotinin Activity</atitle><jtitle>Japanese journal of pharmacology</jtitle><addtitle>Jpn.J.Pharmacol.</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>36</volume><issue>2</issue><spage>197</spage><epage>203</epage><pages>197-203</pages><issn>0021-5198</issn><eissn>1347-3506</eissn><coden>JJPAAZ</coden><abstract>Following preincubation of aprotinin with gelatin, the inhibitory effect on the trypsin activity was enhanced under the same condition as in the case of enhanced antigen-antibody reaction of aprotinin in gel in the presence of gelatin. In the immunochemical titration of aprotinin, gelatin treatment decreased the value of the equivalence point of aprotinin. Immunoprecipitation of aprotinin pre-incubated with or without gelatin adjusted to equal activity per unit volume resulted in overlapping equivalence points. These data suggest that the increase in aprotinin activity in the presence of gelatin is due to increase in the active form of aprotinin.</abstract><cop>Kyoto</cop><pub>The Japanese Pharmacological Society</pub><pmid>6210387</pmid><doi>10.1254/jjp.36.197</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0021-5198 |
| ispartof | The Japanese Journal of Pharmacology, 1984, Vol.36(2), pp.197-203 |
| issn | 0021-5198 1347-3506 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Free Full-Text Journals in Chemistry |
| subjects | Antigen-Antibody Reactions - drug effects Aprotinin - immunology Aprotinin - pharmacology Biological and medical sciences Digestive system Gelatin - pharmacology Humans Immunochemistry Immunodiffusion Immunoglobulin G - biosynthesis Medical sciences Pharmacology. Drug treatments Trypsin - pharmacology |
| title | The Enhancing Effect of Gelatin on Aprotinin Activity |
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