SPECIES DIFFERENCE IN THE INHIBITION OF DRUG METABOLISM BY LIVER MICROSOMES BY DIFFERENT INHIBITORS

It has been reported that the activities of drug-metabolizing enzymes of liver microsomes are inhibited by different kind of drugs (1). SKF 525-A (β-diethylaminoethyl-diphenylpropylacetate HCl) was discovered for the first time and it has been known as the most popular and typical inhibitor of micro...

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Veröffentlicht in:	Japanese journal of pharmacology 1969, Vol.19(3), pp.438-450
Hauptverfasser:	KATO, RYUICHI, ONODA, KINICHI, TAKAYANAGI, MICHIKO
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopyrine - metabolism Aniline Compounds - metabolism Animals Cocaine - metabolism Depression, Chemical Drug Antagonism Ethylamines - pharmacology Hexobarbital - metabolism Histamine H1 Antagonists - pharmacology Kinetics Male Meperidine - metabolism Mice Microsomes, Liver - metabolism Morphine - metabolism Nitrophenols - metabolism Oxidation-Reduction Pentobarbital - metabolism Pharmaceutical Preparations - metabolism Phenacetin - metabolism Phenylhydrazines - pharmacology Piperazines - pharmacology Proadifen - pharmacology Rabbits Rats Species Specificity Zoxazolamine - metabolism
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