Effects of drugs on cells in tissue culture. 2nd report

Effects of drugs on cells in tissue culture. 2nd report

The toxicity of drugs was determined using embryonic skin and muscle from humans (Flow 1, 000). The dosage causing a 50% inhibition culture growth (ID50) and minimum concentration, caused by the detachment of the cell from the vessel wall, were determined. ID50 values of ibuprofen, naproxen, Y-5554,...

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Veröffentlicht in:Folia Pharmacologica Japonica 1975, Vol.71(3), pp.301-305
Hauptverfasser: MUKAIDE, Atsushi, KAMEYAMA, Tsutomu
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container_title Folia Pharmacologica Japonica
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creator MUKAIDE, Atsushi
KAMEYAMA, Tsutomu
description The toxicity of drugs was determined using embryonic skin and muscle from humans (Flow 1, 000). The dosage causing a 50% inhibition culture growth (ID50) and minimum concentration, caused by the detachment of the cell from the vessel wall, were determined. ID50 values of ibuprofen, naproxen, Y-5554, dichlofenac and aminopyrine were found to be 150, 320, 220, 110 and >500 μg/ ml respectively. Minimum concentration, caused by the detachment of the from the vessel wall, was as follows: ibuprofen 250, naproxen 250 ?? 500, Y-5554 250 ?? 500, dichlofenac 62.50 ?? 125 and aminopyrine 1, 000 ?? 2, 000 μg/ml respectively.
doi_str_mv 10.1254/fpj.71.301
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