Studies on the distribution of antitumor amino acid related compounds by whole body autoradiography in mice

Four novel antitumor amino acid related compounds were labeled with 14C and the distribution was studied in mice. *A-91 was excreted into the bile, and a high level of radioactivity in the blood was maintained throughout the 24 hr of experiment. A high radio-activity was seen in the liver, lung, kidney, urinary bladder, and tumor. *A-145 was rapidly distributed to each tissue from the blood, especially to the pancreas, salivary glands, gastrointestinal tract, tumor, and other growing and secreting tissue. *A-192 was excreted into the bile and a high level of radioactivity was seen in the blood. A high radioactivity was detected in the liver, lung, kidney, uterus, ovary, and tumor, followed by a reduction paralleled with a concentration in the blood. *A-192 was rapidly excreted into the urine and very little radioactivity was observed in almost all organs and tissues, except for the central nervous system. *Cyclophosphamide was also rapidly excreted into the urine and bile, but only slight activity was observed in most organs. *Tryptophan, *isoleucine, *valinethese three had the same distribution patterns, and were incorporated into the growing and secreting tissues, pancreas, salivary glands, gastrointestinal tract, tumor, etc.