Pharmacological studies of lithium salts. III. General pharmacological actions of LiCI on cardiovascular system and smooth muscles
LiCl caused a temporary fall followed by a continuous rise on blood pressure in rat, cat and dog. The temporary fall on blood pressure was not suppressed by atropine, propranolol, diphenhydramine and vagotomy. The continuous rise was suppressed by phentolamine, hexamethonium, chlorpromazine, reserpi...
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| Veröffentlicht in: | Folia Pharmacologica Japonica 1974, Vol.70(2), pp.215-230 |
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| Sprache: | eng ; jpn |
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| container_title | Folia Pharmacologica Japonica |
| container_volume | 70 |
| creator | OZAWA, Hikaru MIYAUCHI, Tatsuo SUGAWARA, Kazunobu SASAJIMA, Michitada AIHARA, Hironaka SAKAI, Takeshi TANAKA, Ichiro |
| description | LiCl caused a temporary fall followed by a continuous rise on blood pressure in rat, cat and dog. The temporary fall on blood pressure was not suppressed by atropine, propranolol, diphenhydramine and vagotomy. The continuous rise was suppressed by phentolamine, hexamethonium, chlorpromazine, reserpine and pithed treatment, and only a temporary rise was observed. Also, LiCl potentiated the effects of norepinephrine and tyramine on blood pressure. Furthermore, LiCl resulted in an increased action of cardiac force and output, and a dilative action of peripheral vessels. On the other hand, LiCl had no effect on smooth muscle preparations. From these results, it is concluded that LiCl in a relatively high dose influences the circulatory system through a central action as well as direct action on the peripheral vessels and the heart muscle. |
| doi_str_mv | 10.1254/fpj.70.215 |
| format | Article |
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III. General pharmacological actions of LiCI on cardiovascular system and smooth muscles</title><source>EZB-FREE-00999 freely available EZB journals</source><creator>OZAWA, Hikaru ; MIYAUCHI, Tatsuo ; SUGAWARA, Kazunobu ; SASAJIMA, Michitada ; AIHARA, Hironaka ; SAKAI, Takeshi ; TANAKA, Ichiro</creator><creatorcontrib>OZAWA, Hikaru ; MIYAUCHI, Tatsuo ; SUGAWARA, Kazunobu ; SASAJIMA, Michitada ; AIHARA, Hironaka ; SAKAI, Takeshi ; TANAKA, Ichiro</creatorcontrib><description>LiCl caused a temporary fall followed by a continuous rise on blood pressure in rat, cat and dog. The temporary fall on blood pressure was not suppressed by atropine, propranolol, diphenhydramine and vagotomy. The continuous rise was suppressed by phentolamine, hexamethonium, chlorpromazine, reserpine and pithed treatment, and only a temporary rise was observed. Also, LiCl potentiated the effects of norepinephrine and tyramine on blood pressure. Furthermore, LiCl resulted in an increased action of cardiac force and output, and a dilative action of peripheral vessels. On the other hand, LiCl had no effect on smooth muscle preparations. From these results, it is concluded that LiCl in a relatively high dose influences the circulatory system through a central action as well as direct action on the peripheral vessels and the heart muscle.</description><identifier>ISSN: 0015-5691</identifier><identifier>EISSN: 1347-8397</identifier><identifier>DOI: 10.1254/fpj.70.215</identifier><language>eng ; jpn</language><publisher>The Japanese Pharmacological Society</publisher><ispartof>Folia Pharmacologica Japonica, 1974, Vol.70(2), pp.215-230</ispartof><rights>The Japanese PharmacologicalSociety</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids></links><search><creatorcontrib>OZAWA, Hikaru</creatorcontrib><creatorcontrib>MIYAUCHI, Tatsuo</creatorcontrib><creatorcontrib>SUGAWARA, Kazunobu</creatorcontrib><creatorcontrib>SASAJIMA, Michitada</creatorcontrib><creatorcontrib>AIHARA, Hironaka</creatorcontrib><creatorcontrib>SAKAI, Takeshi</creatorcontrib><creatorcontrib>TANAKA, Ichiro</creatorcontrib><title>Pharmacological studies of lithium salts. 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From these results, it is concluded that LiCl in a relatively high dose influences the circulatory system through a central action as well as direct action on the peripheral vessels and the heart muscle.</abstract><pub>The Japanese Pharmacological Society</pub><doi>10.1254/fpj.70.215</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Folia Pharmacologica Japonica, 1974, Vol.70(2), pp.215-230 |
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| language | eng ; jpn |
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| source | EZB-FREE-00999 freely available EZB journals |
| title | Pharmacological studies of lithium salts. III. General pharmacological actions of LiCI on cardiovascular system and smooth muscles |
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