Pharmacological and clinical study results of trastuzumab deruxtecan (T-DXd, ENHERTU®)

Antibody-drug conjugates (ADCs) combine the specific antibody and cytotoxic agent by a linker and represent a promising drug class with a wider therapeutic window than conventional chemotherapeutic agents by substantiating efficient and specific drug delivery to antigen-expressing tumor cells. Howev...

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Veröffentlicht in:	Folia Pharmacologica Japonica 2021, Vol.156(1), pp.47-51
Hauptverfasser:	Saito, Kaku, Kaneko, Reina, Kamio, Takahiro, Kamiyama, Emi, Muto, Ryo, Sugihara, Masahiro
Format:	Artikel
Sprache:	jpn
Schlagworte:	Antibodies, Monoclonal, Humanized - therapeutic use Antineoplastic Agents - therapeutic use Breast Neoplasms - drug therapy Camptothecin - analogs & derivatives Humans Immunoconjugates Japan Receptor, ErbB-2 - therapeutic use Trastuzumab - therapeutic use
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