Effect of T-593 on gastric bleeding and lesions induced by indomethacin and water-immersion stress in rats: improving effect of T-593 on reduced gastric mucosal blood flow in rats

The effect of T-593, a novel antiulcer agent, was investigated with respect to gastric bleeding and lesions induced by indomethacin (3 mg/kg, s.c.) and water (23 degrees C) immersion stress (IM-WIS) with perfusion of HCl (0.13N) into the rat stomach. It was found that the total amounts of gastric bl...

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Veröffentlicht in:	Nihon yakurigaku zasshi 1998-08, Vol.112 (2), p.117-124
Hauptverfasser:	Arai, H, Mizuo, M, Marubuchi, S, Nakagawa, M, Mori, Y
Format:	Artikel
Sprache:	jpn
Schlagworte:	Animals Anti-Inflammatory Agents - adverse effects Anti-Ulcer Agents - pharmacology Gastric Mucosa - blood supply Guanidines - pharmacology Histamine H2 Antagonists - pharmacology Immersion - adverse effects Indomethacin - adverse effects Male Nitric Oxide - physiology Peptic Ulcer Hemorrhage - drug therapy Peptic Ulcer Hemorrhage - etiology Rats Rats, Wistar Regional Blood Flow - drug effects Steroids Stimulation, Chemical Stomach Ulcer - drug therapy Stomach Ulcer - etiology Stress, Physiological - complications Sulfones - pharmacology
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