Effects of SL-1010 (sodium hyaluronate with high molecular weight) on experimental osteoarthritis induced by intra-articularly applied papain in guinea pigs

Effects of SL-1010 on the experimental osteoarthritis (OA) produced by intra-articular injection of papain, proteolytic enzyme, in the knee joint of the guinea pigs were histologically and biochemically investigated. In addition, experimental conditions to produce OA in guinea pig knee joint were al...

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Veröffentlicht in:	Folia Pharmacologica Japonica 1992, Vol.100(1), pp.77-86
Hauptverfasser:	TANAKA, Hirokazu, KITOH, Yasuhiko, KATSURAMAKI, Tsuneo, TANAKA, Michiko, KITABAYASHI, Noriko, FUJIMORI, Shigeki, UMEMOTO, Jyunji, NAMBA, Kazuhiko
Format:	Artikel
Sprache:	jpn
Schlagworte:	Animals Cartilage, Articular - chemistry Cartilage, Articular - drug effects Cartilage, Articular - pathology Female Glycosaminoglycans - analysis Guinea Pigs Hyaluronic Acid - administration & dosage Hyaluronic Acid - pharmacology Injections, Intra-Articular Knee Joint - pathology Microscopy, Electron Molecular Weight Osteoarthritis - chemically induced Osteoarthritis - drug therapy Osteoarthritis - pathology Papain - administration & dosage Papain - pharmacology
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