Mechanisms Underlying Nano-Sized Air-Pollution-Mediated Progression of Atherosclerosis: Carbon Black Causes Cytotoxic Injury/Inflammation and Inhibits Cell Growth in Vascular Endothelial Cells

Background Epidemiological studies indicate a significant link between exposure to environmental air pollution and mortality and morbidity from ischemic heart disease. Because nanoparticles can translocate into blood circulation, the present study aimed to clarify their direct effects on human vascu...

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Veröffentlicht in:	Circulation Journal 2006, Vol.70(1), pp.129-140
Hauptverfasser:	Yamawaki, Hideyuki, Iwai, Naoharu
Format:	Artikel
Sprache:	eng
Schlagworte:	Air pollution Air Pollution - adverse effects Atherosclerosis Atherosclerosis - physiopathology Carbon - toxicity Cell death Cell Division - drug effects Cell Survival - drug effects Cells, Cultured Chemokine CCL2 - metabolism Disease Progression Endothelium Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Endothelium, Vascular - ultrastructure Gene Expression Regulation - drug effects Humans Inflammation Nanostructures Oligonucleotide Array Sequence Analysis - methods Umbilical Veins
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