Wire-Induced Myocardial Ischemia: A Novel Approach to Create Myocardial Ischemia in Rats
Background Animal models are indispensable in order to investigate the mechanism of various diseases and to explore the counter measures for those disease states. Although there are several animal models of ischemic heart diseases, surgical interventions required to create myocardial ischemia someti...
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| Veröffentlicht in: | Circulation Journal 2004, Vol.68(4), pp.371-375 |
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| container_end_page | 375 |
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| container_issue | 4 |
| container_start_page | 371 |
| container_title | Circulation Journal |
| container_volume | 68 |
| creator | Urasawa, Kazushi Sakai, Hidetsugu Saito, Takahiko Oyama, Naotsugu Kaneta, Satoshi Kitabatake, Akira |
| description | Background Animal models are indispensable in order to investigate the mechanism of various diseases and to explore the counter measures for those disease states. Although there are several animal models of ischemic heart diseases, surgical interventions required to create myocardial ischemia sometimes give rise to a problem in the yield of model. This study describes a new technique for inducing myocardial ischemia in rats. Methods and Results A 0.014-inch guidewire was introduced via the carotid artery and selectively advanced into the coronary arteries under fluoroscopy. Transmural myocardial ischemia was confirmed by ST-segment elevation and by the appearance of left ventricular wall motion abnormalities on the echocardiogram. Reversibility of the wire-induced myocardial ischemia was demonstrated by complete resolution of both ST-segment elevation and wall motion abnormalities after removing the wire. Conclusion Wire-induced myocardial ischemia was reproducible and is less invasive than conventional ischemic models in rats. This method is a powerful and useful tool for the investigation of ischemic heart disease in small animals. (Circ J 2004; 68: 371 - 375) |
| doi_str_mv | 10.1253/circj.68.371 |
| format | Article |
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Although there are several animal models of ischemic heart diseases, surgical interventions required to create myocardial ischemia sometimes give rise to a problem in the yield of model. This study describes a new technique for inducing myocardial ischemia in rats. Methods and Results A 0.014-inch guidewire was introduced via the carotid artery and selectively advanced into the coronary arteries under fluoroscopy. Transmural myocardial ischemia was confirmed by ST-segment elevation and by the appearance of left ventricular wall motion abnormalities on the echocardiogram. Reversibility of the wire-induced myocardial ischemia was demonstrated by complete resolution of both ST-segment elevation and wall motion abnormalities after removing the wire. Conclusion Wire-induced myocardial ischemia was reproducible and is less invasive than conventional ischemic models in rats. This method is a powerful and useful tool for the investigation of ischemic heart disease in small animals. 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Although there are several animal models of ischemic heart diseases, surgical interventions required to create myocardial ischemia sometimes give rise to a problem in the yield of model. This study describes a new technique for inducing myocardial ischemia in rats. Methods and Results A 0.014-inch guidewire was introduced via the carotid artery and selectively advanced into the coronary arteries under fluoroscopy. Transmural myocardial ischemia was confirmed by ST-segment elevation and by the appearance of left ventricular wall motion abnormalities on the echocardiogram. Reversibility of the wire-induced myocardial ischemia was demonstrated by complete resolution of both ST-segment elevation and wall motion abnormalities after removing the wire. Conclusion Wire-induced myocardial ischemia was reproducible and is less invasive than conventional ischemic models in rats. This method is a powerful and useful tool for the investigation of ischemic heart disease in small animals. (Circ J 2004; 68: 371 - 375)</description><subject>Animal model</subject><subject>Animals</subject><subject>Cardiac Catheterization - instrumentation</subject><subject>Coronary Disease - etiology</subject><subject>Electrocardiography</subject><subject>Embolism - etiology</subject><subject>Male</subject><subject>Microspheres</subject><subject>Models, Animal</subject><subject>Myocardial infarction</subject><subject>Myocardial ischemia</subject><subject>Myocardial Ischemia - diagnostic imaging</subject><subject>Myocardial Ischemia - etiology</subject><subject>Myocardial Ischemia - physiopathology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reproducibility of Results</subject><subject>Sepharose - administration & dosage</subject><subject>Sepharose - toxicity</subject><subject>Ultrasonography</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFj0tLAzEQgIMotlZvnqU_wK2ZvHMsxcdCxYviMWSTWbulL5L20H_v2i3uZWZgPj74CLkHOgEm-VNoUlhOlJlwDRdkCFzoQhhGL0-3KqwRfEBucl5SyiyV9poMQFKpDNdDMv5uEhblJh4CxvH7cRt8io1fjcscFrhu_C25qv0q4915j8jXy_Pn7K2Yf7yWs-m8CNwYKIyXTKCKRnKmKh4rVEoBKKyURbBaUF4LoUMNWtua1SpGbiGGKjBbaQl8RB47b0jbnBPWbpeatU9HB9T9hbpTqFPGtaEt_tDhu0O1xtjD57IWmHbAMu_9D_4DPu2bsMLeJrrRSvvfwieHG_4LNjxlCA</recordid><startdate>200404</startdate><enddate>200404</enddate><creator>Urasawa, Kazushi</creator><creator>Sakai, Hidetsugu</creator><creator>Saito, Takahiko</creator><creator>Oyama, Naotsugu</creator><creator>Kaneta, Satoshi</creator><creator>Kitabatake, Akira</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200404</creationdate><title>Wire-Induced Myocardial Ischemia</title><author>Urasawa, Kazushi ; Sakai, Hidetsugu ; Saito, Takahiko ; Oyama, Naotsugu ; Kaneta, Satoshi ; Kitabatake, Akira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3881-8a524e6d85326b3dbe666116eb69e197403f447cf1779f2f6dd391dcbc29b7513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animal model</topic><topic>Animals</topic><topic>Cardiac Catheterization - instrumentation</topic><topic>Coronary Disease - etiology</topic><topic>Electrocardiography</topic><topic>Embolism - etiology</topic><topic>Male</topic><topic>Microspheres</topic><topic>Models, Animal</topic><topic>Myocardial infarction</topic><topic>Myocardial ischemia</topic><topic>Myocardial Ischemia - diagnostic imaging</topic><topic>Myocardial Ischemia - etiology</topic><topic>Myocardial Ischemia - physiopathology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reproducibility of Results</topic><topic>Sepharose - administration & dosage</topic><topic>Sepharose - toxicity</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Urasawa, Kazushi</creatorcontrib><creatorcontrib>Sakai, Hidetsugu</creatorcontrib><creatorcontrib>Saito, Takahiko</creatorcontrib><creatorcontrib>Oyama, Naotsugu</creatorcontrib><creatorcontrib>Kaneta, Satoshi</creatorcontrib><creatorcontrib>Kitabatake, Akira</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Urasawa, Kazushi</au><au>Sakai, Hidetsugu</au><au>Saito, Takahiko</au><au>Oyama, Naotsugu</au><au>Kaneta, Satoshi</au><au>Kitabatake, Akira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Wire-Induced Myocardial Ischemia: A Novel Approach to Create Myocardial Ischemia in Rats</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2004-04</date><risdate>2004</risdate><volume>68</volume><issue>4</issue><spage>371</spage><epage>375</epage><pages>371-375</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Background Animal models are indispensable in order to investigate the mechanism of various diseases and to explore the counter measures for those disease states. Although there are several animal models of ischemic heart diseases, surgical interventions required to create myocardial ischemia sometimes give rise to a problem in the yield of model. This study describes a new technique for inducing myocardial ischemia in rats. Methods and Results A 0.014-inch guidewire was introduced via the carotid artery and selectively advanced into the coronary arteries under fluoroscopy. Transmural myocardial ischemia was confirmed by ST-segment elevation and by the appearance of left ventricular wall motion abnormalities on the echocardiogram. Reversibility of the wire-induced myocardial ischemia was demonstrated by complete resolution of both ST-segment elevation and wall motion abnormalities after removing the wire. Conclusion Wire-induced myocardial ischemia was reproducible and is less invasive than conventional ischemic models in rats. This method is a powerful and useful tool for the investigation of ischemic heart disease in small animals. (Circ J 2004; 68: 371 - 375)</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>15056837</pmid><doi>10.1253/circj.68.371</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animal model Animals Cardiac Catheterization - instrumentation Coronary Disease - etiology Electrocardiography Embolism - etiology Male Microspheres Models, Animal Myocardial infarction Myocardial ischemia Myocardial Ischemia - diagnostic imaging Myocardial Ischemia - etiology Myocardial Ischemia - physiopathology Rats Rats, Wistar Reproducibility of Results Sepharose - administration & dosage Sepharose - toxicity Ultrasonography |
| title | Wire-Induced Myocardial Ischemia: A Novel Approach to Create Myocardial Ischemia in Rats |
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