Association between Distigmine-induced Adverse Events and Serum Butyrylcholinesterase Level : A Multicenter Retrospective Study
Distigmine sometimes causes severe adverse events, and the serum butyrylcholinesterase (BChE) level is reduced by distigmine. However, limited data are available on the association between serum BChE level and the risk of distigmine-induced adverse events. To clarify the association between the risk...
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| Veröffentlicht in: | YAKUGAKU ZASSHI (Journal of the Pharmaceutical Society of Japan) 2022-09, Vol.142 (9), p.993-998, Article 22-00078 |
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| container_title | YAKUGAKU ZASSHI (Journal of the Pharmaceutical Society of Japan) |
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| creator | Mitsuboshi, Satoru Otaki, Shota Kaneko, Chikashi Tsuruma, Naoki |
| description | Distigmine sometimes causes severe adverse events, and the serum butyrylcholinesterase (BChE) level is reduced by distigmine. However, limited data are available on the association between serum BChE level and the risk of distigmine-induced adverse events. To clarify the association between the risk of distigmine-induced adverse events and serum BChE level, we retrospectively reviewed 371 patients with 2199 measurements of serum BChE levels at three hospitals, of whom 24 (6.5%) had adverse events. Multivariate logistic regression analysis was performed to identify risk factors associated with adverse events of distigmine. The risk of adverse events was associated with distigmine dose > 0.15 mg/kg/d [odds ratio (OR) 3.55, 95% confidence interval (CI) 1.07-11.70, p=0.04], serum BChE level 80-112 U/L (OR 3.13, 95% CI 1.03-9.52, p=0.04), and serum BChE level < 80 U/L (OR 13.70, 95% CI 5.14-36.50, p |
| doi_str_mv | 10.1248/yakushi.22-00078 |
| format | Article |
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However, limited data are available on the association between serum BChE level and the risk of distigmine-induced adverse events. To clarify the association between the risk of distigmine-induced adverse events and serum BChE level, we retrospectively reviewed 371 patients with 2199 measurements of serum BChE levels at three hospitals, of whom 24 (6.5%) had adverse events. Multivariate logistic regression analysis was performed to identify risk factors associated with adverse events of distigmine. The risk of adverse events was associated with distigmine dose > 0.15 mg/kg/d [odds ratio (OR) 3.55, 95% confidence interval (CI) 1.07-11.70, p=0.04], serum BChE level 80-112 U/L (OR 3.13, 95% CI 1.03-9.52, p=0.04), and serum BChE level < 80 U/L (OR 13.70, 95% CI 5.14-36.50, p<0.01). Serum BChE might be a useful biomarker for estimating the risk of distigmine-induced adverse events. The risk of adverse events might be decreased by closely monitoring serum BChE and assessing distigmine dose in patients with high risk factors.</description><identifier>ISSN: 0031-6903</identifier><identifier>EISSN: 1347-5231</identifier><identifier>DOI: 10.1248/yakushi.22-00078</identifier><language>eng ; jpn</language><publisher>Pharmaceutical Society of Japan</publisher><ispartof>YAKUGAKU ZASSHI (Journal of the Pharmaceutical Society of Japan), 2022-09, Vol.142 (9), p.993-998, Article 22-00078</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c476t-d2aad54bb8bd3609cf9afcbdb39e7fd6084f0f2ac5e797c13ec1ba4fa884a023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Mitsuboshi, Satoru</creatorcontrib><creatorcontrib>Otaki, Shota</creatorcontrib><creatorcontrib>Kaneko, Chikashi</creatorcontrib><creatorcontrib>Tsuruma, Naoki</creatorcontrib><creatorcontrib>Sado General Hospital</creatorcontrib><creatorcontrib>aDepartment of Pharmacy</creatorcontrib><creatorcontrib>Niitsu Medical Center Hospital</creatorcontrib><creatorcontrib>cDepartment of Pharmacy</creatorcontrib><creatorcontrib>bDepartment of Pharmacy</creatorcontrib><creatorcontrib>Kaetsu Hospital</creatorcontrib><title>Association between Distigmine-induced Adverse Events and Serum Butyrylcholinesterase Level : A Multicenter Retrospective Study</title><title>YAKUGAKU ZASSHI (Journal of the Pharmaceutical Society of Japan)</title><description>Distigmine sometimes causes severe adverse events, and the serum butyrylcholinesterase (BChE) level is reduced by distigmine. However, limited data are available on the association between serum BChE level and the risk of distigmine-induced adverse events. To clarify the association between the risk of distigmine-induced adverse events and serum BChE level, we retrospectively reviewed 371 patients with 2199 measurements of serum BChE levels at three hospitals, of whom 24 (6.5%) had adverse events. Multivariate logistic regression analysis was performed to identify risk factors associated with adverse events of distigmine. The risk of adverse events was associated with distigmine dose > 0.15 mg/kg/d [odds ratio (OR) 3.55, 95% confidence interval (CI) 1.07-11.70, p=0.04], serum BChE level 80-112 U/L (OR 3.13, 95% CI 1.03-9.52, p=0.04), and serum BChE level < 80 U/L (OR 13.70, 95% CI 5.14-36.50, p<0.01). Serum BChE might be a useful biomarker for estimating the risk of distigmine-induced adverse events. The risk of adverse events might be decreased by closely monitoring serum BChE and assessing distigmine dose in patients with high risk factors.</description><issn>0031-6903</issn><issn>1347-5231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNotkEtPwzAQhC0EElXhztF_ILB-5MWtlFKQipCgd8uxN2BIE2Q7RTnx10lo97BzmW81O4RcMbhmXBY3g_7qw4e75jwBgLw4ITMmZJ6kXLBTMgMQLMlKEOfkMgRXAfBxUlbMyO8ihM44HV3X0grjD2JL712I7n3nWkxca3uDli7sHn1AutpjGwPVraVv6Psdvevj4IfGfHTN6A8RvR5tG9xjQ2_pgj73TXRmhNDTV4y-C99ootsjfYu9HS7IWa2bgJdHnZPtw2q7fEw2L-un5WKTGJlnMbFca5vKqioqKzIoTV3q2lS2EiXmtc2gkDXUXJsU8zI3TKBhlZa1LgqpgYs5gcNZMwYIHmv17d1O-0ExUFOF6lih4lz9Vzgi6wOyQ-uMbrp2elB9dr1vx6TKhHxi3hWHiWGSQzkKU1CWYlqFhCyVIhN_BS2BiQ</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Mitsuboshi, Satoru</creator><creator>Otaki, Shota</creator><creator>Kaneko, Chikashi</creator><creator>Tsuruma, Naoki</creator><general>Pharmaceutical Society of Japan</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20220901</creationdate><title>Association between Distigmine-induced Adverse Events and Serum Butyrylcholinesterase Level : A Multicenter Retrospective Study</title><author>Mitsuboshi, Satoru ; Otaki, Shota ; Kaneko, Chikashi ; Tsuruma, Naoki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-d2aad54bb8bd3609cf9afcbdb39e7fd6084f0f2ac5e797c13ec1ba4fa884a023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; jpn</language><creationdate>2022</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mitsuboshi, Satoru</creatorcontrib><creatorcontrib>Otaki, Shota</creatorcontrib><creatorcontrib>Kaneko, Chikashi</creatorcontrib><creatorcontrib>Tsuruma, Naoki</creatorcontrib><creatorcontrib>Sado General Hospital</creatorcontrib><creatorcontrib>aDepartment of Pharmacy</creatorcontrib><creatorcontrib>Niitsu Medical Center Hospital</creatorcontrib><creatorcontrib>cDepartment of Pharmacy</creatorcontrib><creatorcontrib>bDepartment of Pharmacy</creatorcontrib><creatorcontrib>Kaetsu Hospital</creatorcontrib><collection>CrossRef</collection><jtitle>YAKUGAKU ZASSHI (Journal of the Pharmaceutical Society of Japan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mitsuboshi, Satoru</au><au>Otaki, Shota</au><au>Kaneko, Chikashi</au><au>Tsuruma, Naoki</au><aucorp>Sado General Hospital</aucorp><aucorp>aDepartment of Pharmacy</aucorp><aucorp>Niitsu Medical Center Hospital</aucorp><aucorp>cDepartment of Pharmacy</aucorp><aucorp>bDepartment of Pharmacy</aucorp><aucorp>Kaetsu Hospital</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between Distigmine-induced Adverse Events and Serum Butyrylcholinesterase Level : A Multicenter Retrospective Study</atitle><jtitle>YAKUGAKU ZASSHI (Journal of the Pharmaceutical Society of Japan)</jtitle><date>2022-09-01</date><risdate>2022</risdate><volume>142</volume><issue>9</issue><spage>993</spage><epage>998</epage><pages>993-998</pages><artnum>22-00078</artnum><issn>0031-6903</issn><eissn>1347-5231</eissn><abstract>Distigmine sometimes causes severe adverse events, and the serum butyrylcholinesterase (BChE) level is reduced by distigmine. However, limited data are available on the association between serum BChE level and the risk of distigmine-induced adverse events. To clarify the association between the risk of distigmine-induced adverse events and serum BChE level, we retrospectively reviewed 371 patients with 2199 measurements of serum BChE levels at three hospitals, of whom 24 (6.5%) had adverse events. Multivariate logistic regression analysis was performed to identify risk factors associated with adverse events of distigmine. The risk of adverse events was associated with distigmine dose > 0.15 mg/kg/d [odds ratio (OR) 3.55, 95% confidence interval (CI) 1.07-11.70, p=0.04], serum BChE level 80-112 U/L (OR 3.13, 95% CI 1.03-9.52, p=0.04), and serum BChE level < 80 U/L (OR 13.70, 95% CI 5.14-36.50, p<0.01). Serum BChE might be a useful biomarker for estimating the risk of distigmine-induced adverse events. The risk of adverse events might be decreased by closely monitoring serum BChE and assessing distigmine dose in patients with high risk factors.</abstract><pub>Pharmaceutical Society of Japan</pub><doi>10.1248/yakushi.22-00078</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng ; jpn |
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| source | J-STAGE Free; Alma/SFX Local Collection |
| title | Association between Distigmine-induced Adverse Events and Serum Butyrylcholinesterase Level : A Multicenter Retrospective Study |
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