Statistical Approach to the Drug-Induced Taste Disorders Based on Zinc Chelating Ability
Various drug-induced taste disorders have been ascribed to zinc deficiency in serum. Assuming that the zinc deficiency is caused by the chelating reaction of zinc ions with drugs, the electrode potential of the Zn2+/Zn(Hg) system was measured in the presence of drugs in water, ethanol, and N,N-dimet...
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| Veröffentlicht in: | YAKUGAKU ZASSHI 2005/04/01, Vol.125(4), pp.377-387 |
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| container_title | YAKUGAKU ZASSHI |
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| creator | FUKASAWA, Takashi ORII, Takao TANAKA, Masayo YANO, Seiji SUZUKI, Noriko KANZAKI, Yasushi |
| description | Various drug-induced taste disorders have been ascribed to zinc deficiency in serum. Assuming that the zinc deficiency is caused by the chelating reaction of zinc ions with drugs, the electrode potential of the Zn2+/Zn(Hg) system was measured in the presence of drugs in water, ethanol, and N,N-dimethylformamide (DMF). The zinc-chelating ability was estimated based on the potential change ΔE2 with the addition of a drug. A large potential change suggesting potent chelating ability was observed in penicillamine, furosemide, and ibuprofen in ethanol and in fluorouracil, acetazolamide, and bezafibrate in DMF. Multiple regression analysis was used to evaluate the observed ΔE2 in mV to represent chelating ability. The regression equation to estimate the frequency of taste disorders was deduced from ΔE2, and frequency of four drugs appeared in package inserts and interview forms. According to the regression equation, the frequency of taste disorders was successfully estimated for 14 drugs examined in this study. The result was examined in a clinical case. |
| doi_str_mv | 10.1248/yakushi.125.377 |
| format | Article |
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Assuming that the zinc deficiency is caused by the chelating reaction of zinc ions with drugs, the electrode potential of the Zn2+/Zn(Hg) system was measured in the presence of drugs in water, ethanol, and N,N-dimethylformamide (DMF). The zinc-chelating ability was estimated based on the potential change ΔE2 with the addition of a drug. A large potential change suggesting potent chelating ability was observed in penicillamine, furosemide, and ibuprofen in ethanol and in fluorouracil, acetazolamide, and bezafibrate in DMF. Multiple regression analysis was used to evaluate the observed ΔE2 in mV to represent chelating ability. The regression equation to estimate the frequency of taste disorders was deduced from ΔE2, and frequency of four drugs appeared in package inserts and interview forms. According to the regression equation, the frequency of taste disorders was successfully estimated for 14 drugs examined in this study. The result was examined in a clinical case.</description><identifier>ISSN: 0031-6903</identifier><identifier>EISSN: 1347-5231</identifier><identifier>DOI: 10.1248/yakushi.125.377</identifier><identifier>PMID: 15802884</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Adult ; Aged ; Chelating Agents ; Dose-Response Relationship, Drug ; drug-induced disorder ; Drug-Related Side Effects and Adverse Reactions ; Ethanol ; Female ; Humans ; Ion-Selective Electrodes ; Male ; Middle Aged ; Molecular Weight ; Multivariate Analysis ; Solubility ; taste disorder ; Taste Disorders - chemically induced ; Taste Disorders - epidemiology ; Water ; Zinc - deficiency ; zinc amalgam electrode ; zinc chelate</subject><ispartof>YAKUGAKU ZASSHI, 2005/04/01, Vol.125(4), pp.377-387</ispartof><rights>2005 by the PHARMACEUTICAL SOCIETY OF JAPAN</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c677t-a442c465fea2ca0ffb9c5209ae5ff8d9ad1afff41acbaeba2f8f732ee918c6ac3</citedby><cites>FETCH-LOGICAL-c677t-a442c465fea2ca0ffb9c5209ae5ff8d9ad1afff41acbaeba2f8f732ee918c6ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15802884$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FUKASAWA, Takashi</creatorcontrib><creatorcontrib>ORII, Takao</creatorcontrib><creatorcontrib>TANAKA, Masayo</creatorcontrib><creatorcontrib>YANO, Seiji</creatorcontrib><creatorcontrib>SUZUKI, Noriko</creatorcontrib><creatorcontrib>KANZAKI, Yasushi</creatorcontrib><creatorcontrib>Pharmacy Department</creatorcontrib><creatorcontrib>Saiseikai Yokohamashi Nanbu Hospital</creatorcontrib><creatorcontrib>FCG Research Institute Incorporation</creatorcontrib><creatorcontrib>Kanto Medical Center NTT EC</creatorcontrib><creatorcontrib>Showa Pharmaceutical University</creatorcontrib><title>Statistical Approach to the Drug-Induced Taste Disorders Based on Zinc Chelating Ability</title><title>YAKUGAKU ZASSHI</title><addtitle>YAKUGAKU ZASSHI</addtitle><description>Various drug-induced taste disorders have been ascribed to zinc deficiency in serum. Assuming that the zinc deficiency is caused by the chelating reaction of zinc ions with drugs, the electrode potential of the Zn2+/Zn(Hg) system was measured in the presence of drugs in water, ethanol, and N,N-dimethylformamide (DMF). The zinc-chelating ability was estimated based on the potential change ΔE2 with the addition of a drug. A large potential change suggesting potent chelating ability was observed in penicillamine, furosemide, and ibuprofen in ethanol and in fluorouracil, acetazolamide, and bezafibrate in DMF. Multiple regression analysis was used to evaluate the observed ΔE2 in mV to represent chelating ability. The regression equation to estimate the frequency of taste disorders was deduced from ΔE2, and frequency of four drugs appeared in package inserts and interview forms. According to the regression equation, the frequency of taste disorders was successfully estimated for 14 drugs examined in this study. The result was examined in a clinical case.</description><subject>Adult</subject><subject>Aged</subject><subject>Chelating Agents</subject><subject>Dose-Response Relationship, Drug</subject><subject>drug-induced disorder</subject><subject>Drug-Related Side Effects and Adverse Reactions</subject><subject>Ethanol</subject><subject>Female</subject><subject>Humans</subject><subject>Ion-Selective Electrodes</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Molecular Weight</subject><subject>Multivariate Analysis</subject><subject>Solubility</subject><subject>taste disorder</subject><subject>Taste Disorders - chemically induced</subject><subject>Taste Disorders - epidemiology</subject><subject>Water</subject><subject>Zinc - deficiency</subject><subject>zinc amalgam electrode</subject><subject>zinc chelate</subject><issn>0031-6903</issn><issn>1347-5231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1v1DAQhi0EokvhzA35D6T1Z-Icl6WllSpxoJUqLtbEsTde0mRlO4f998xqtyAuY83MO894XkI-c3bFhTLXB_i95CFioq9k07whKy5VU2kh-VuyYkzyqm6ZvCAfct4xJqTU-j254NowYYxakeefBUrMJToY6Xq_TzO4gZaZlsHTb2nZVvdTvzjf00fIBUsxz6n3KdOvkLE6T_RXnBzdDH5E0LSl6y6OsRw-kncBxuw_nd9L8nR787i5qx5-fL_frB8qVzdNqUAp4VStgwfhgIXQtU4L1oLXIZi-hZ5DCEFxcB34DkQwoZHC-5YbV4OTl-T6xHVpzjn5YPcpvkA6WM7s0SN79ggTbdEjnPhymtgv3Yvv_-nPpqDg9iTA7tGXeRrj5O1uXtKEp1iXmyNzawVj2jLkMoXbassQj8E00uANHEE3J9AuF9j6v5sgod-j_-9n6hyPiNe-GyBZP8k_TWOVvA</recordid><startdate>20050401</startdate><enddate>20050401</enddate><creator>FUKASAWA, Takashi</creator><creator>ORII, Takao</creator><creator>TANAKA, Masayo</creator><creator>YANO, Seiji</creator><creator>SUZUKI, Noriko</creator><creator>KANZAKI, Yasushi</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20050401</creationdate><title>Statistical Approach to the Drug-Induced Taste Disorders Based on Zinc Chelating Ability</title><author>FUKASAWA, Takashi ; ORII, Takao ; TANAKA, Masayo ; YANO, Seiji ; SUZUKI, Noriko ; KANZAKI, Yasushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c677t-a442c465fea2ca0ffb9c5209ae5ff8d9ad1afff41acbaeba2f8f732ee918c6ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Chelating Agents</topic><topic>Dose-Response Relationship, Drug</topic><topic>drug-induced disorder</topic><topic>Drug-Related Side Effects and Adverse Reactions</topic><topic>Ethanol</topic><topic>Female</topic><topic>Humans</topic><topic>Ion-Selective Electrodes</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Molecular Weight</topic><topic>Multivariate Analysis</topic><topic>Solubility</topic><topic>taste disorder</topic><topic>Taste Disorders - chemically induced</topic><topic>Taste Disorders - epidemiology</topic><topic>Water</topic><topic>Zinc - deficiency</topic><topic>zinc amalgam electrode</topic><topic>zinc chelate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FUKASAWA, Takashi</creatorcontrib><creatorcontrib>ORII, Takao</creatorcontrib><creatorcontrib>TANAKA, Masayo</creatorcontrib><creatorcontrib>YANO, Seiji</creatorcontrib><creatorcontrib>SUZUKI, Noriko</creatorcontrib><creatorcontrib>KANZAKI, Yasushi</creatorcontrib><creatorcontrib>Pharmacy Department</creatorcontrib><creatorcontrib>Saiseikai Yokohamashi Nanbu Hospital</creatorcontrib><creatorcontrib>FCG Research Institute Incorporation</creatorcontrib><creatorcontrib>Kanto Medical Center NTT EC</creatorcontrib><creatorcontrib>Showa Pharmaceutical University</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>YAKUGAKU ZASSHI</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FUKASAWA, Takashi</au><au>ORII, Takao</au><au>TANAKA, Masayo</au><au>YANO, Seiji</au><au>SUZUKI, Noriko</au><au>KANZAKI, Yasushi</au><aucorp>Pharmacy Department</aucorp><aucorp>Saiseikai Yokohamashi Nanbu Hospital</aucorp><aucorp>FCG Research Institute Incorporation</aucorp><aucorp>Kanto Medical Center NTT EC</aucorp><aucorp>Showa Pharmaceutical University</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Statistical Approach to the Drug-Induced Taste Disorders Based on Zinc Chelating Ability</atitle><jtitle>YAKUGAKU ZASSHI</jtitle><addtitle>YAKUGAKU ZASSHI</addtitle><date>2005-04-01</date><risdate>2005</risdate><volume>125</volume><issue>4</issue><spage>377</spage><epage>387</epage><pages>377-387</pages><issn>0031-6903</issn><eissn>1347-5231</eissn><abstract>Various drug-induced taste disorders have been ascribed to zinc deficiency in serum. Assuming that the zinc deficiency is caused by the chelating reaction of zinc ions with drugs, the electrode potential of the Zn2+/Zn(Hg) system was measured in the presence of drugs in water, ethanol, and N,N-dimethylformamide (DMF). The zinc-chelating ability was estimated based on the potential change ΔE2 with the addition of a drug. A large potential change suggesting potent chelating ability was observed in penicillamine, furosemide, and ibuprofen in ethanol and in fluorouracil, acetazolamide, and bezafibrate in DMF. Multiple regression analysis was used to evaluate the observed ΔE2 in mV to represent chelating ability. The regression equation to estimate the frequency of taste disorders was deduced from ΔE2, and frequency of four drugs appeared in package inserts and interview forms. According to the regression equation, the frequency of taste disorders was successfully estimated for 14 drugs examined in this study. The result was examined in a clinical case.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>15802884</pmid><doi>10.1248/yakushi.125.377</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | YAKUGAKU ZASSHI, 2005/04/01, Vol.125(4), pp.377-387 |
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| source | MEDLINE; Alma/SFX Local Collection; J-STAGE |
| subjects | Adult Aged Chelating Agents Dose-Response Relationship, Drug drug-induced disorder Drug-Related Side Effects and Adverse Reactions Ethanol Female Humans Ion-Selective Electrodes Male Middle Aged Molecular Weight Multivariate Analysis Solubility taste disorder Taste Disorders - chemically induced Taste Disorders - epidemiology Water Zinc - deficiency zinc amalgam electrode zinc chelate |
| title | Statistical Approach to the Drug-Induced Taste Disorders Based on Zinc Chelating Ability |
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