Essential Role of Ascorbic Acid in Neural Differentiation and Development: High Levels of Ascorbic Acid 2-Glucoside Effectively Enhance Nerve Growth Factor-Induced Neurite Formation and Elongation in PC12 Cells

Essential Role of Ascorbic Acid in Neural Differentiation and Development: High Levels of Ascorbic Acid 2-Glucoside Effectively Enhance Nerve Growth Factor-Induced Neurite Formation and Elongation in PC12 Cells

The aim of this study was to investigate the role of ascorbic acid (AsA) in neural differentiation induced by nerve growth factor (NGF) in PC12 cells, a neural precursor cell line. Cells were cultivated in the presence of L-ascorbic acid-2-O-α-D-glucopyranoside (AA-2G) and evaluated for potentiation...

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Veröffentlicht in:Journal of Health Science 2008, Vol.54(1), pp.43-49
Hauptverfasser: Haramoto, Mari, Tatemoto, Hideki, Muto, Norio
Format: Artikel
Sprache:eng
Schlagworte:
ascorbic acid
ascorbic acid 2-glucoside
differentiation
neurite formation
PC12 cell
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Zusammenfassung:The aim of this study was to investigate the role of ascorbic acid (AsA) in neural differentiation induced by nerve growth factor (NGF) in PC12 cells, a neural precursor cell line. Cells were cultivated in the presence of L-ascorbic acid-2-O-α-D-glucopyranoside (AA-2G) and evaluated for potentiation of neural differentiation induced by a small amount of NGF. AA-2G enhanced the proportion of neurite-bearing cells in a concentration-dependent manner (
ISSN:1344-9702
1347-5207
DOI:10.1248/jhs.54.43