N-Alkylated 1, 4-Dihydropyridines : New Agents to Overcome Multidrug Resistance

New N-alkylated 1, 4-dihydropyridine derivatives were synthesized and their ability to overcome multidrug resistance was examined in vincristine-resistant P388 cells (P388/VCR cells). Compounds that possessed an arylalkyl substituent on the dihydropyridine ring nitrogen were more potent than verapam...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1995/05/15, Vol.43(5), pp.818-828
Hauptverfasser:	OHSUMI, Koji, OHISHI, Kazuo, MORINAGA, Yoshihiro, NAKAGAWA, Ryusuke, SUGA, Yasuyo, SEKIYAMA, Takaaki, AKIYAMA, Yukio, TSUJI, Takashi, TSURUO, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Animals Antineoplastic agents Biological and medical sciences Chemical Phenomena Chemistry, Physical Dihydropyridines - chemical synthesis Dihydropyridines - metabolism Dihydropyridines - pharmacology Drug Resistance, Multiple - physiology Drug Resistance, Neoplasm Female General aspects Leukemia P388 - drug therapy Magnetic Resonance Spectroscopy Medical sciences Mice Mice, Inbred BALB C Mice, Inbred DBA multidrug resistance N-alkylated 1, 4-dihydropyridine Pharmacology. Drug treatments Stereoisomerism Structure-Activity Relationship Tumor Cells, Cultured verapamil Verapamil - pharmacology vincristine Vincristine - toxicity
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