CHEMICAL TRANSFORMATION FROM DIHYDROISOCOUMARIN INTO BENZYLIDENEPHTHALIDE BY USE OF REGIOSPECIFIC OXIDATIVE LACTONIZATION MEDIATED BY COPPER CHLORIDE (II) : SYNTHESES OF THUNBERGINOL F AND HYDRAMACROPHYLLOL A AND B

CHEMICAL TRANSFORMATION FROM DIHYDROISOCOUMARIN INTO BENZYLIDENEPHTHALIDE BY USE OF REGIOSPECIFIC OXIDATIVE LACTONIZATION MEDIATED BY COPPER CHLORIDE (II) : SYNTHESES OF THUNBERGINOL F AND HYDRAMACROPHYLLOL A AND B

Oxidative lactonization of 2-carboxystilbene mediated by CuCl2 proceeded regiospecifically to give the five-membered lactone. By utilizing this lactonization as a key reaction, chemical transformation from dihydroisocoumarine into benzylidenephthalide was accomplished, and it was applied to structur...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical & pharmaceutical bulletin 1994/03/15, Vol.42(3), pp.721-723
Hauptverfasser: YOSHIKAWA, Masayuki, HARADA, Emiko, YAGI, Nobuhiro, OKUNO, Yasuhiro, MURAOKA, Osamu, AOYAMA, Hiroshi, MURAKAMI, Nobutoshi
Format: Artikel
Sprache:eng
Schlagworte:
benzylidenephthalide
copper chloride (II)
dihydroisocoumarin
hydramacrophyllol
oxidative lactonization
thunberginol F
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Oxidative lactonization of 2-carboxystilbene mediated by CuCl2 proceeded regiospecifically to give the five-membered lactone. By utilizing this lactonization as a key reaction, chemical transformation from dihydroisocoumarine into benzylidenephthalide was accomplished, and it was applied to structural elucidation of two new phthalide, hydramacrophyllols A and B.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.42.721