Structures of Americanol A and Isoamericanol A Having a Neurotrophic Property from the Seeds of Phytolacca americana

Structures of Americanol A and Isoamericanol A Having a Neurotrophic Property from the Seeds of Phytolacca americana

The structures of new neo-lignans, isoamericanol A (1) and americanol A (2) isolated from the seeds of Phytolacca americana have been elucidated on the basis of spectroscopic data and then confirmed by chemical correlation with the previouslty known isoamericanin A (3) and americanin A (4). Isoameri...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1992/01/25, Vol.40(1), pp.252-254
Hauptverfasser: FUKUYAMA, Yoshiyasu, HASEGAWA, Takashi, TODA, Miki, KODAMA, Mitsuaki, OKAZAKI, Hiroshi
Format: Artikel
Sprache:eng
Schlagworte:
1, 4-benzodioxane
americanin A
americanol A
Animals
Biological and medical sciences
Brain - drug effects
Brain - enzymology
Chemistry
Chemistry, Medicinal
Chemistry, Multidisciplinary
choline acetyltransferase
Choline O-Acetyltransferase - metabolism
Dioxanes - analysis
Dioxanes - pharmacology
Enzyme Activation
Female
General pharmacology
isoamericanin A
isoamericanol A
Life Sciences & Biomedicine
Medical sciences
neo-lignan
Neurons - drug effects
Neurons - enzymology
neurotrophic activity
Pharmacognosy. Homeopathy. Health food
Pharmacology & Pharmacy
Pharmacology. Drug treatments
Physical Sciences
Phytolacca americana
Phytolaccaceae
Plants, Medicinal - chemistry
Pregnancy
Rats
Science & Technology
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Beschreibung
Zusammenfassung:The structures of new neo-lignans, isoamericanol A (1) and americanol A (2) isolated from the seeds of Phytolacca americana have been elucidated on the basis of spectroscopic data and then confirmed by chemical correlation with the previouslty known isoamericanin A (3) and americanin A (4). Isoamericanol A, americanol A, and americanin A have been found to enhance choline acetyltransferase activity at 10-5 M in a cultured neuronal cell system derived from fetal rat hemisphere.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.40.252