A synthetic method suitable for the rapid preparation of 13N-labeled dermorphin analogue, H-Tyr-D-Met(O)-Phe-Gly-NH2 (SD-62)
A synthetic method suitable for the preparation of 13N-labeled dermorphin analogue, H-Tyr-D-Met(O)-Phe-Gly-NH2 (SD-62), was established; i.e., SD-62 was synthesized by a 5 min treatment of the active ester precursor with ammonia. When the 13N-labeled SD-62, prepared by this method with [13N]ammonia,...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1991, Vol.39 (10), p.2734-2736 |
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| container_end_page | 2736 |
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| container_issue | 10 |
| container_start_page | 2734 |
| container_title | Chemical & pharmaceutical bulletin |
| container_volume | 39 |
| creator | KISO, Y IINUMA, S MIMOTO, T SAJI, H YOKOYAMA, A AKAJI, K |
| description | A synthetic method suitable for the preparation of 13N-labeled dermorphin analogue, H-Tyr-D-Met(O)-Phe-Gly-NH2 (SD-62), was established; i.e., SD-62 was synthesized by a 5 min treatment of the active ester precursor with ammonia. When the 13N-labeled SD-62, prepared by this method with [13N]ammonia, was administered into mice, the time profile of the radioactivity accumulation in the brain paralleled well that of the analgesic activity. |
| doi_str_mv | 10.1248/cpb.39.2734 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0009-2363 |
| ispartof | Chemical & pharmaceutical bulletin, 1991, Vol.39 (10), p.2734-2736 |
| issn | 0009-2363 1347-5223 |
| language | eng |
| recordid | cdi_crossref_primary_10_1248_cpb_39_2734 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Analgesics, Opioid - chemical synthesis Analgesics, Opioid - metabolism Brain - metabolism Chemistry Exact sciences and technology Hydrolysis Nitrogen Radioisotopes Oligopeptides - chemical synthesis Oligopeptides - metabolism Opioid Peptides Organic chemistry Peptides Preparations and properties |
| title | A synthetic method suitable for the rapid preparation of 13N-labeled dermorphin analogue, H-Tyr-D-Met(O)-Phe-Gly-NH2 (SD-62) |
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