Biological Activities of Chemically Synthesized Derivatives of Lipid A : Tetraacetyl-monosaccharides Linked to 2, 3-Acyloxyacylglucosamine-4-phosphate

The mitogenicity and lethal toxicity of chemically synthesized lipid A analogs, in which 2, 3-acyloxyacyl-glucosamine-4-phosphate (acyl-GlcN-4P) is linked to a tetraacetyl (Ac4)-monosaccharide, i.e., Ac4-glucose (A-211), Ac4-mannose (A-212), Ac4-galactose (A-213) or Ac4-glucosamine (A-214), were com...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1989/09/25, Vol.37(9), pp.2535-2536
Hauptverfasser:	SHIMIZU, Tadayori, MASUZAWA, Toshiyuki, YANAGIHARA, Yasutake, ITOH, Hajime, NAKAMOTO, Shin-ichi, ACHIWA, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteriology Biological and medical sciences Fundamental and applied biological sciences. Psychology Lethal Dose 50 lethal toxicity Lipid A - analogs & derivatives Lipid A - chemical synthesis Lipid A - pharmacology lipopolysaccharide Male Mice Mice, Inbred C57BL Microbiology mitogenicity Mitogens - chemical synthesis Monosaccharides Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains synthetic lipid A analog
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