Potentiating Effects of β-Eudesmol-Related Cyclohexylidene Derivatives on Succinylcholine-Induced Neuromuscular Block in Isolated Phrenic Nerve-Diaphragm Muscles of Normal and Alloxan-Diabetic Mice

β-Eudesmol, a sesquiterpenoid alcohol contained in Atractylodes lancea, potentiates succinylcholine (SuCh)-induced neuromuscular blockade. The potentiating effect is greater in diabetic muscles than in normal ones. As a ligand for affinity chromatography to study the potentiating mechanism, we desig...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 1995/03/15, Vol.18(3), pp.407-410
Hauptverfasser:	KIMURA, Masayasu, DIWAN, Prakash, YANAGI, Seiji, KONNO, Yasuo, NOJIMA, Hiroshi, KIMURA, Ikuko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cyclohexanes - chemical synthesis Cyclohexanes - pharmacology cyclohexylidene derivative Diabetes Mellitus, Experimental - physiopathology diabetic mouse Diaphragm - drug effects Diaphragm - innervation Drug Synergism Drugs, Chinese Herbal - pharmacology Male Medical sciences Mice Mice, Inbred Strains Muscle Contraction - drug effects neuromuscular blockade Neuromuscular Blocking Agents - chemical synthesis Neuromuscular Blocking Agents - pharmacology Neuromuscular Junction - drug effects Pharmacology. Drug treatments Phrenic Nerve - drug effects potentiation Respiratory system Sesquiterpenes, Eudesmane Stimulation, Chemical succinylcholine Succinylcholine - pharmacology Synaptic Transmission - drug effects Terpenes - pharmacology β-eudesmol-related compound
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