Anti-arrhythmic effect of nadolol in experimental arrhythmias: comparison with propranolol and alprenolol
The effects of nadolol on experimental arrhythmias were investigated and compared with those of propranolol and alprenolol. The arrhythmias were induced by either ouabain, holothane plus adrenaline or acute coronary occlusion in anesthetized dogs. All three beta-blocking drugs in a dose range of 10...
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| Veröffentlicht in: | Journal of pharmacobio-dynamics 1985, Vol.8 (1), p.1-10 |
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| container_title | Journal of pharmacobio-dynamics |
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| creator | NAKASHIMA, M TAKIGUCHI, Y OGURO, K SOGABE, K HASHIMOTO, H |
| description | The effects of nadolol on experimental arrhythmias were investigated and compared with those of propranolol and alprenolol. The arrhythmias were induced by either ouabain, holothane plus adrenaline or acute coronary occlusion in anesthetized dogs. All three beta-blocking drugs in a dose range of 10 to 200 micrograms/kg inhibited halothane plus adrenaline-induced arrhythmias. These drugs also attenuated coronary occlusion-induced ventricular arrhythmias as well as other electrical abnormalities such as electrical alternation and conduction delay. Among the three drugs, nadolol was the most potent in suppressing both types of arrhythmias. Contrary to the potent effects on these arrhythmias, nadolol was ineffective against ouabain-induced arrhythmias even in a dose of 3 mg kg, while propranolol and alprenolol were significantly effective in a dose of 100 micrograms/kg. It is probable that the anti-arrhythmic effect of nadolol is exclusively due to its beta-blocking activity. |
| doi_str_mv | 10.1248/bpb1978.8.1 |
| format | Article |
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The arrhythmias were induced by either ouabain, holothane plus adrenaline or acute coronary occlusion in anesthetized dogs. All three beta-blocking drugs in a dose range of 10 to 200 micrograms/kg inhibited halothane plus adrenaline-induced arrhythmias. These drugs also attenuated coronary occlusion-induced ventricular arrhythmias as well as other electrical abnormalities such as electrical alternation and conduction delay. Among the three drugs, nadolol was the most potent in suppressing both types of arrhythmias. Contrary to the potent effects on these arrhythmias, nadolol was ineffective against ouabain-induced arrhythmias even in a dose of 3 mg kg, while propranolol and alprenolol were significantly effective in a dose of 100 micrograms/kg. It is probable that the anti-arrhythmic effect of nadolol is exclusively due to its beta-blocking activity.</description><identifier>ISSN: 0386-846X</identifier><identifier>EISSN: 1881-1353</identifier><identifier>DOI: 10.1248/bpb1978.8.1</identifier><identifier>PMID: 4009395</identifier><identifier>CODEN: JOPHDQ</identifier><language>eng</language><publisher>Tokyo: Pharmaceutical Society of Japan</publisher><subject>Alprenolol - therapeutic use ; Anesthesia ; Animals ; Anti-Arrhythmia Agents - therapeutic use ; Antiarythmic agents ; Arrhythmias, Cardiac - chemically induced ; Arrhythmias, Cardiac - drug therapy ; Arrhythmias, Cardiac - etiology ; Biological and medical sciences ; Cardiovascular system ; Coronary Disease - complications ; Dogs ; Epinephrine ; Female ; Halothane ; Male ; Medical sciences ; Nadolol ; Ouabain ; Pharmacology. Drug treatments ; Propanolamines - therapeutic use ; Propranolol - therapeutic use</subject><ispartof>Journal of pharmacobio-dynamics, 1985, Vol.8 (1), p.1-10</ispartof><rights>1986 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-8abf15c14f899123963c61edcd70bd886a5edaca33b4660ec6945a93b59a94183</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8411662$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4009395$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NAKASHIMA, M</creatorcontrib><creatorcontrib>TAKIGUCHI, Y</creatorcontrib><creatorcontrib>OGURO, K</creatorcontrib><creatorcontrib>SOGABE, K</creatorcontrib><creatorcontrib>HASHIMOTO, H</creatorcontrib><title>Anti-arrhythmic effect of nadolol in experimental arrhythmias: comparison with propranolol and alprenolol</title><title>Journal of pharmacobio-dynamics</title><addtitle>J Pharmacobiodyn</addtitle><description>The effects of nadolol on experimental arrhythmias were investigated and compared with those of propranolol and alprenolol. The arrhythmias were induced by either ouabain, holothane plus adrenaline or acute coronary occlusion in anesthetized dogs. All three beta-blocking drugs in a dose range of 10 to 200 micrograms/kg inhibited halothane plus adrenaline-induced arrhythmias. These drugs also attenuated coronary occlusion-induced ventricular arrhythmias as well as other electrical abnormalities such as electrical alternation and conduction delay. Among the three drugs, nadolol was the most potent in suppressing both types of arrhythmias. Contrary to the potent effects on these arrhythmias, nadolol was ineffective against ouabain-induced arrhythmias even in a dose of 3 mg kg, while propranolol and alprenolol were significantly effective in a dose of 100 micrograms/kg. It is probable that the anti-arrhythmic effect of nadolol is exclusively due to its beta-blocking activity.</description><subject>Alprenolol - therapeutic use</subject><subject>Anesthesia</subject><subject>Animals</subject><subject>Anti-Arrhythmia Agents - therapeutic use</subject><subject>Antiarythmic agents</subject><subject>Arrhythmias, Cardiac - chemically induced</subject><subject>Arrhythmias, Cardiac - drug therapy</subject><subject>Arrhythmias, Cardiac - etiology</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Coronary Disease - complications</subject><subject>Dogs</subject><subject>Epinephrine</subject><subject>Female</subject><subject>Halothane</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nadolol</subject><subject>Ouabain</subject><subject>Pharmacology. Drug treatments</subject><subject>Propanolamines - therapeutic use</subject><subject>Propranolol - therapeutic use</subject><issn>0386-846X</issn><issn>1881-1353</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LAzEQhoMotVZPnoUcvMnWTJNNE2-l-AUFLwreltlsQiP7EZIV7b93bZeehuF9Zph5CLkGNoeFUPdlKEEv1VzN4YRMQSnIgOf8lEwZVzJTQn6ek4uUvhgTWuUwIRPBmOY6nxK_anufYYzbXb9tvKHWOWt62jnaYtXVXU19S-1vsNE3tu2xpkcY0wM1XRMw-tS19Mf3WxpiFyK2-0FsK4p1iHbfXpIzh3WyV2OdkY-nx_f1S7Z5e35drzaZESD7TGHpIDcgnNIaFlxLbiTYylRLVlZKScxthQY5L4WUzBqpRY6al7lGLUDxGbk77DWxSylaV4ThdIy7Aljx76sYfRWqgIG-OdDhu2xsdWRHQUN-O-aYDNZu-M34dMSUAJBywf8AN1t1lg</recordid><startdate>1985</startdate><enddate>1985</enddate><creator>NAKASHIMA, M</creator><creator>TAKIGUCHI, Y</creator><creator>OGURO, K</creator><creator>SOGABE, K</creator><creator>HASHIMOTO, H</creator><general>Pharmaceutical Society of Japan</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1985</creationdate><title>Anti-arrhythmic effect of nadolol in experimental arrhythmias: comparison with propranolol and alprenolol</title><author>NAKASHIMA, M ; TAKIGUCHI, Y ; OGURO, K ; SOGABE, K ; HASHIMOTO, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-8abf15c14f899123963c61edcd70bd886a5edaca33b4660ec6945a93b59a94183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Alprenolol - therapeutic use</topic><topic>Anesthesia</topic><topic>Animals</topic><topic>Anti-Arrhythmia Agents - therapeutic use</topic><topic>Antiarythmic agents</topic><topic>Arrhythmias, Cardiac - chemically induced</topic><topic>Arrhythmias, Cardiac - drug therapy</topic><topic>Arrhythmias, Cardiac - etiology</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular system</topic><topic>Coronary Disease - complications</topic><topic>Dogs</topic><topic>Epinephrine</topic><topic>Female</topic><topic>Halothane</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nadolol</topic><topic>Ouabain</topic><topic>Pharmacology. Drug treatments</topic><topic>Propanolamines - therapeutic use</topic><topic>Propranolol - therapeutic use</topic><toplevel>online_resources</toplevel><creatorcontrib>NAKASHIMA, M</creatorcontrib><creatorcontrib>TAKIGUCHI, Y</creatorcontrib><creatorcontrib>OGURO, K</creatorcontrib><creatorcontrib>SOGABE, K</creatorcontrib><creatorcontrib>HASHIMOTO, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of pharmacobio-dynamics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NAKASHIMA, M</au><au>TAKIGUCHI, Y</au><au>OGURO, K</au><au>SOGABE, K</au><au>HASHIMOTO, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-arrhythmic effect of nadolol in experimental arrhythmias: comparison with propranolol and alprenolol</atitle><jtitle>Journal of pharmacobio-dynamics</jtitle><addtitle>J Pharmacobiodyn</addtitle><date>1985</date><risdate>1985</risdate><volume>8</volume><issue>1</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>0386-846X</issn><eissn>1881-1353</eissn><coden>JOPHDQ</coden><abstract>The effects of nadolol on experimental arrhythmias were investigated and compared with those of propranolol and alprenolol. The arrhythmias were induced by either ouabain, holothane plus adrenaline or acute coronary occlusion in anesthetized dogs. All three beta-blocking drugs in a dose range of 10 to 200 micrograms/kg inhibited halothane plus adrenaline-induced arrhythmias. These drugs also attenuated coronary occlusion-induced ventricular arrhythmias as well as other electrical abnormalities such as electrical alternation and conduction delay. Among the three drugs, nadolol was the most potent in suppressing both types of arrhythmias. Contrary to the potent effects on these arrhythmias, nadolol was ineffective against ouabain-induced arrhythmias even in a dose of 3 mg kg, while propranolol and alprenolol were significantly effective in a dose of 100 micrograms/kg. It is probable that the anti-arrhythmic effect of nadolol is exclusively due to its beta-blocking activity.</abstract><cop>Tokyo</cop><pub>Pharmaceutical Society of Japan</pub><pmid>4009395</pmid><doi>10.1248/bpb1978.8.1</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0386-846X |
| ispartof | Journal of pharmacobio-dynamics, 1985, Vol.8 (1), p.1-10 |
| issn | 0386-846X 1881-1353 |
| language | eng |
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| source | J-STAGE Free; MEDLINE; EZB Electronic Journals Library |
| subjects | Alprenolol - therapeutic use Anesthesia Animals Anti-Arrhythmia Agents - therapeutic use Antiarythmic agents Arrhythmias, Cardiac - chemically induced Arrhythmias, Cardiac - drug therapy Arrhythmias, Cardiac - etiology Biological and medical sciences Cardiovascular system Coronary Disease - complications Dogs Epinephrine Female Halothane Male Medical sciences Nadolol Ouabain Pharmacology. Drug treatments Propanolamines - therapeutic use Propranolol - therapeutic use |
| title | Anti-arrhythmic effect of nadolol in experimental arrhythmias: comparison with propranolol and alprenolol |
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