Effects of a New Dihydropyridine Derivative, FRC-8653, on Blood Pressure in Conscious Spontaneously Hypertensive Rats
Antihypertensive effects of FRC-8653, a new 1, 4-dihydropyridine derivative, and its combined effects with an angiotensin converting enzyme (ACE) inhibitor, a diuretic, and a β-adrenergic blocking agent were examined in conscious spontaneously hypertensive rats (SHR). When administered intravenously...
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| Veröffentlicht in: | Journal of Pharmacobio-Dynamics 1992, Vol.15(1), pp.25-32 |
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| creator | YOSHIMOTO, Ryota HASHIGUCHI, Yukari DOHMOTO, Hideki HOSONO, Masahiro IIDA, Hiroyuki FUJIYOSHI, Toshio IKEDA, Kenro HAYASHI, Yutaka |
| description | Antihypertensive effects of FRC-8653, a new 1, 4-dihydropyridine derivative, and its combined effects with an angiotensin converting enzyme (ACE) inhibitor, a diuretic, and a β-adrenergic blocking agent were examined in conscious spontaneously hypertensive rats (SHR). When administered intravenously to SHR (10, 30μg/kg), FRC-8653 lowered blood pressure more slowly and sustained it longer than nifedipine and nicardipine. Consecutive once-daily administrations of FRC-8653 to SHR (3 mg/kg, p.o.) produced a stable reduction of blood pressure throughout the experimental period of 29 d. When blood pressure was continuously measured for 24 h in conscious unrestricted SHR, orally administered FRC-8653 produced a long-lasting reduction in blood pressure. When concomitantly used with atenolol (30 mg/kg, p.o.), the antihypertensive effect of FRC-8653 was augmented in both potency and duration. However, simultaneous administration of captopril (30 mg/kg, p.o.) or hydrochlorothiazide (2.5 mg/kg, p.o.) did not modify the antihypertensive effect of FRC-8653. |
| doi_str_mv | 10.1248/bpb1978.15.25 |
| format | Article |
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When administered intravenously to SHR (10, 30μg/kg), FRC-8653 lowered blood pressure more slowly and sustained it longer than nifedipine and nicardipine. Consecutive once-daily administrations of FRC-8653 to SHR (3 mg/kg, p.o.) produced a stable reduction of blood pressure throughout the experimental period of 29 d. When blood pressure was continuously measured for 24 h in conscious unrestricted SHR, orally administered FRC-8653 produced a long-lasting reduction in blood pressure. When concomitantly used with atenolol (30 mg/kg, p.o.), the antihypertensive effect of FRC-8653 was augmented in both potency and duration. However, simultaneous administration of captopril (30 mg/kg, p.o.) or hydrochlorothiazide (2.5 mg/kg, p.o.) did not modify the antihypertensive effect of FRC-8653.</description><identifier>ISSN: 0386-846X</identifier><identifier>EISSN: 1881-1353</identifier><identifier>DOI: 10.1248/bpb1978.15.25</identifier><identifier>PMID: 1608038</identifier><identifier>CODEN: JOPHDQ</identifier><language>eng</language><publisher>TOKYO: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Antihypertensive agents ; Antihypertensive Agents - pharmacology ; Atenolol - pharmacology ; Biological and medical sciences ; Blood Pressure - drug effects ; calcium antagonist ; Captopril - pharmacology ; Cardiovascular system ; Dihydropyridines - pharmacology ; Heart Rate - drug effects ; Hydrochlorothiazide - pharmacology ; Hypertension - physiopathology ; Life Sciences & Biomedicine ; Male ; Medical sciences ; Pharmacology & Pharmacy ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred SHR ; Science & Technology</subject><ispartof>Journal of Pharmacobio-Dynamics, 1992, Vol.15(1), pp.25-32</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1992 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>12</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wosA1992HG31800004</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c582t-38dcde2063d244cd5fac5905020fee55a3a8566d07c3bcb0890910a97b419b0c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>310,311,315,781,785,790,791,1884,4025,4051,4052,23935,23936,25145,27197,27928,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5282882$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1608038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YOSHIMOTO, Ryota</creatorcontrib><creatorcontrib>HASHIGUCHI, Yukari</creatorcontrib><creatorcontrib>DOHMOTO, Hideki</creatorcontrib><creatorcontrib>HOSONO, Masahiro</creatorcontrib><creatorcontrib>IIDA, Hiroyuki</creatorcontrib><creatorcontrib>FUJIYOSHI, Toshio</creatorcontrib><creatorcontrib>IKEDA, Kenro</creatorcontrib><creatorcontrib>HAYASHI, Yutaka</creatorcontrib><title>Effects of a New Dihydropyridine Derivative, FRC-8653, on Blood Pressure in Conscious Spontaneously Hypertensive Rats</title><title>Journal of Pharmacobio-Dynamics</title><addtitle>J PHARMACOBIO-DYNAM</addtitle><addtitle>Journal of Pharmacobio-Dynamics</addtitle><description>Antihypertensive effects of FRC-8653, a new 1, 4-dihydropyridine derivative, and its combined effects with an angiotensin converting enzyme (ACE) inhibitor, a diuretic, and a β-adrenergic blocking agent were examined in conscious spontaneously hypertensive rats (SHR). When administered intravenously to SHR (10, 30μg/kg), FRC-8653 lowered blood pressure more slowly and sustained it longer than nifedipine and nicardipine. Consecutive once-daily administrations of FRC-8653 to SHR (3 mg/kg, p.o.) produced a stable reduction of blood pressure throughout the experimental period of 29 d. When blood pressure was continuously measured for 24 h in conscious unrestricted SHR, orally administered FRC-8653 produced a long-lasting reduction in blood pressure. When concomitantly used with atenolol (30 mg/kg, p.o.), the antihypertensive effect of FRC-8653 was augmented in both potency and duration. However, simultaneous administration of captopril (30 mg/kg, p.o.) or hydrochlorothiazide (2.5 mg/kg, p.o.) did not modify the antihypertensive effect of FRC-8653.</description><subject>Animals</subject><subject>Antihypertensive agents</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Atenolol - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>calcium antagonist</subject><subject>Captopril - pharmacology</subject><subject>Cardiovascular system</subject><subject>Dihydropyridines - pharmacology</subject><subject>Heart Rate - drug effects</subject><subject>Hydrochlorothiazide - pharmacology</subject><subject>Hypertension - physiopathology</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology & Pharmacy</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Science & Technology</subject><issn>0386-846X</issn><issn>1881-1353</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EZCTM</sourceid><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAUhS0EKkNhyRLJC8SGZvAjzjjLNn0MUgWogMQucpxr6ipjp7bTKv8eo4ymLPHCtnS-c3R9jNBbStaUlfJTN3a03sg1FWsmnqEVlZIWlAv-HK0Il1Uhy-rXS_QqxjtCyloKeoSOaEVkFldoujAGdIrYG6zwF3jE5_Z27oMf52B76wCfQ7APKtkHOMGXN00hK8FPsHf4bPC-x98CxDgFwNbhxruorZ8i_j56l5SDfB9mvJ1HCAlczCH4RqX4Gr0waojwZn8eo5-XFz-abXH99epzc3pdaCFZKrjsdQ-MVLxnZal7YZQWNRGEEQMghOJKiqrqyUbzTndE1qSmRNWbrqR1RzQ_Rh-W3DH4-wlianc2ahiGZbR2wwmhpagyWCygDj7GAKYdg92pMLeUtH9rbvc1t1S0TGT-3T546nbQP9FLr1l_v9dV1GowQTlt4wETTDIpWcY-LtgjdN7k7sBpOFCntK7Z9opTSfIqMy3_n25syp_mXeMnl7L1bLHexaR-P5lUSFYP8O_r6LIxcRD1rQotOP4HL_2-DA</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>YOSHIMOTO, Ryota</creator><creator>HASHIGUCHI, Yukari</creator><creator>DOHMOTO, Hideki</creator><creator>HOSONO, Masahiro</creator><creator>IIDA, Hiroyuki</creator><creator>FUJIYOSHI, Toshio</creator><creator>IKEDA, Kenro</creator><creator>HAYASHI, Yutaka</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Soc Japan</general><general>Pharmaceutical Society of Japan</general><scope>BLEPL</scope><scope>DTL</scope><scope>EZCTM</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Effects of a New Dihydropyridine Derivative, FRC-8653, on Blood Pressure in Conscious Spontaneously Hypertensive Rats</title><author>YOSHIMOTO, Ryota ; HASHIGUCHI, Yukari ; DOHMOTO, Hideki ; HOSONO, Masahiro ; IIDA, Hiroyuki ; FUJIYOSHI, Toshio ; IKEDA, Kenro ; HAYASHI, Yutaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c582t-38dcde2063d244cd5fac5905020fee55a3a8566d07c3bcb0890910a97b419b0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Antihypertensive agents</topic><topic>Antihypertensive Agents - pharmacology</topic><topic>Atenolol - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>calcium antagonist</topic><topic>Captopril - pharmacology</topic><topic>Cardiovascular system</topic><topic>Dihydropyridines - pharmacology</topic><topic>Heart Rate - drug effects</topic><topic>Hydrochlorothiazide - pharmacology</topic><topic>Hypertension - physiopathology</topic><topic>Life Sciences & Biomedicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology & Pharmacy</topic><topic>Pharmacology. 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When administered intravenously to SHR (10, 30μg/kg), FRC-8653 lowered blood pressure more slowly and sustained it longer than nifedipine and nicardipine. Consecutive once-daily administrations of FRC-8653 to SHR (3 mg/kg, p.o.) produced a stable reduction of blood pressure throughout the experimental period of 29 d. When blood pressure was continuously measured for 24 h in conscious unrestricted SHR, orally administered FRC-8653 produced a long-lasting reduction in blood pressure. When concomitantly used with atenolol (30 mg/kg, p.o.), the antihypertensive effect of FRC-8653 was augmented in both potency and duration. However, simultaneous administration of captopril (30 mg/kg, p.o.) or hydrochlorothiazide (2.5 mg/kg, p.o.) did not modify the antihypertensive effect of FRC-8653.</abstract><cop>TOKYO</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>1608038</pmid><doi>10.1248/bpb1978.15.25</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Web of Science - Science Citation Index Expanded - 1992<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Animals Antihypertensive agents Antihypertensive Agents - pharmacology Atenolol - pharmacology Biological and medical sciences Blood Pressure - drug effects calcium antagonist Captopril - pharmacology Cardiovascular system Dihydropyridines - pharmacology Heart Rate - drug effects Hydrochlorothiazide - pharmacology Hypertension - physiopathology Life Sciences & Biomedicine Male Medical sciences Pharmacology & Pharmacy Pharmacology. Drug treatments Rats Rats, Inbred SHR Science & Technology |
| title | Effects of a New Dihydropyridine Derivative, FRC-8653, on Blood Pressure in Conscious Spontaneously Hypertensive Rats |
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