New Insulinomimetic Zinc(II) Complexes of Nicotinamide and its Derivatives: X-ray Structure and Biochemical Activity

New Insulinomimetic Zinc(II) Complexes of Nicotinamide and its Derivatives: X-ray Structure and Biochemical Activity

Three Zn(II) complexes with nicotinamide(na), nicotinemethylamide(nma), and nicotineethylamide(nea) were found to have in vitro insulinomimetic activities. X-ray structure analysis of [Zn(nea)2(H2O)2(SO4)]n showed that each nitrogen atom of two nea molecules locates trans, and the two water molecule...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemistry letters 2001, Vol.30 (11), p.1184-1185
Hauptverfasser: Ueda, Eriko, Yoshikawa, Yutaka, Kishimoto, Noriko, Tadokoro, Makoto, Yanagihara, Naohisa, Sakurai, Hiromu, Kojima, Yoshitane
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1185
container_issue 11
container_start_page 1184
container_title Chemistry letters
container_volume 30
creator Ueda, Eriko
Yoshikawa, Yutaka
Kishimoto, Noriko
Tadokoro, Makoto
Yanagihara, Naohisa
Sakurai, Hiromu
Kojima, Yoshitane
description Three Zn(II) complexes with nicotinamide(na), nicotinemethylamide(nma), and nicotineethylamide(nea) were found to have in vitro insulinomimetic activities. X-ray structure analysis of [Zn(nea)2(H2O)2(SO4)]n showed that each nitrogen atom of two nea molecules locates trans, and the two water molecules and each oxygen atom of the two sulfates coordinate to a Zn(II) ion, forming an octahedral geometry of Zn(N2O4) unit in an inorganic polymer crystal. The Zn(II) complexes with na, nma, and nea exhibited higher insulinomimetic activities, respective IC50 values (50% inhibition concentration of the complex in the free fatty acids release from rat adipocytes) being 1.34, 1.12, and 0.96 mM, than that of ZnSO4 (IC50 = 1.52 mM).
doi_str_mv 10.1246/cl.2001.1184
format Article
fullrecord <record><control><sourceid>chemicalsocietyjapan_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1246_cl_2001_1184</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_1246_cl_2001_1184</sourcerecordid><originalsourceid>FETCH-LOGICAL-c450t-c1df2c1cea6525fa3b807d12aa8210cfaed9a96ee788af9629619dea0f2e335e3</originalsourceid><addsrcrecordid>eNptkEtLw0AUhQdRsFZ3_oBZKpg6M3k0cVfrK1DqQgVxE643d3BKkikzk2r-vS126erC4TuHy8fYuRQTqZLsGpuJEkJOpMyTAzaScZJHYirTQzYScZZFU6HUMTvxfiWEyItYjVhY0jcvO983prOtaSkY5B-mw4uyvORz264b-iHPreZLgzaYDlpTE4eu5iZ4fkfObCCYDfkb_h45GPhLcD2G3v1Bt8biF7UGoeEz3IImDKfsSEPj6Wx_x-zt4f51_hQtnh_L-WwRYZKKEKGstUKJBFmqUg3xZy6mtVQAuZICNVBdQJERTfMcdJGpIpNFTSC0ojhOKR6zq79ddNZ7R7paO9OCGyopqp2xCptqZ6zaGdvixR7fP-wtGgrDCtbQVSvbu26b_d_9BUZwdCU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>New Insulinomimetic Zinc(II) Complexes of Nicotinamide and its Derivatives: X-ray Structure and Biochemical Activity</title><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Ueda, Eriko ; Yoshikawa, Yutaka ; Kishimoto, Noriko ; Tadokoro, Makoto ; Yanagihara, Naohisa ; Sakurai, Hiromu ; Kojima, Yoshitane</creator><creatorcontrib>Ueda, Eriko ; Yoshikawa, Yutaka ; Kishimoto, Noriko ; Tadokoro, Makoto ; Yanagihara, Naohisa ; Sakurai, Hiromu ; Kojima, Yoshitane</creatorcontrib><description>Three Zn(II) complexes with nicotinamide(na), nicotinemethylamide(nma), and nicotineethylamide(nea) were found to have in vitro insulinomimetic activities. X-ray structure analysis of [Zn(nea)2(H2O)2(SO4)]n showed that each nitrogen atom of two nea molecules locates trans, and the two water molecules and each oxygen atom of the two sulfates coordinate to a Zn(II) ion, forming an octahedral geometry of Zn(N2O4) unit in an inorganic polymer crystal. The Zn(II) complexes with na, nma, and nea exhibited higher insulinomimetic activities, respective IC50 values (50% inhibition concentration of the complex in the free fatty acids release from rat adipocytes) being 1.34, 1.12, and 0.96 mM, than that of ZnSO4 (IC50 = 1.52 mM).</description><identifier>ISSN: 0366-7022</identifier><identifier>EISSN: 1348-0715</identifier><identifier>DOI: 10.1246/cl.2001.1184</identifier><language>eng</language><publisher>The Chemical Society of Japan</publisher><ispartof>Chemistry letters, 2001, Vol.30 (11), p.1184-1185</ispartof><rights>The Chemical Society of Japan</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-c1df2c1cea6525fa3b807d12aa8210cfaed9a96ee788af9629619dea0f2e335e3</citedby><cites>FETCH-LOGICAL-c450t-c1df2c1cea6525fa3b807d12aa8210cfaed9a96ee788af9629619dea0f2e335e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids></links><search><creatorcontrib>Ueda, Eriko</creatorcontrib><creatorcontrib>Yoshikawa, Yutaka</creatorcontrib><creatorcontrib>Kishimoto, Noriko</creatorcontrib><creatorcontrib>Tadokoro, Makoto</creatorcontrib><creatorcontrib>Yanagihara, Naohisa</creatorcontrib><creatorcontrib>Sakurai, Hiromu</creatorcontrib><creatorcontrib>Kojima, Yoshitane</creatorcontrib><title>New Insulinomimetic Zinc(II) Complexes of Nicotinamide and its Derivatives: X-ray Structure and Biochemical Activity</title><title>Chemistry letters</title><addtitle>Chemistry Letters</addtitle><description>Three Zn(II) complexes with nicotinamide(na), nicotinemethylamide(nma), and nicotineethylamide(nea) were found to have in vitro insulinomimetic activities. X-ray structure analysis of [Zn(nea)2(H2O)2(SO4)]n showed that each nitrogen atom of two nea molecules locates trans, and the two water molecules and each oxygen atom of the two sulfates coordinate to a Zn(II) ion, forming an octahedral geometry of Zn(N2O4) unit in an inorganic polymer crystal. The Zn(II) complexes with na, nma, and nea exhibited higher insulinomimetic activities, respective IC50 values (50% inhibition concentration of the complex in the free fatty acids release from rat adipocytes) being 1.34, 1.12, and 0.96 mM, than that of ZnSO4 (IC50 = 1.52 mM).</description><issn>0366-7022</issn><issn>1348-0715</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNptkEtLw0AUhQdRsFZ3_oBZKpg6M3k0cVfrK1DqQgVxE643d3BKkikzk2r-vS126erC4TuHy8fYuRQTqZLsGpuJEkJOpMyTAzaScZJHYirTQzYScZZFU6HUMTvxfiWEyItYjVhY0jcvO983prOtaSkY5B-mw4uyvORz264b-iHPreZLgzaYDlpTE4eu5iZ4fkfObCCYDfkb_h45GPhLcD2G3v1Bt8biF7UGoeEz3IImDKfsSEPj6Wx_x-zt4f51_hQtnh_L-WwRYZKKEKGstUKJBFmqUg3xZy6mtVQAuZICNVBdQJERTfMcdJGpIpNFTSC0ojhOKR6zq79ddNZ7R7paO9OCGyopqp2xCptqZ6zaGdvixR7fP-wtGgrDCtbQVSvbu26b_d_9BUZwdCU</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>Ueda, Eriko</creator><creator>Yoshikawa, Yutaka</creator><creator>Kishimoto, Noriko</creator><creator>Tadokoro, Makoto</creator><creator>Yanagihara, Naohisa</creator><creator>Sakurai, Hiromu</creator><creator>Kojima, Yoshitane</creator><general>The Chemical Society of Japan</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2001</creationdate><title>New Insulinomimetic Zinc(II) Complexes of Nicotinamide and its Derivatives: X-ray Structure and Biochemical Activity</title><author>Ueda, Eriko ; Yoshikawa, Yutaka ; Kishimoto, Noriko ; Tadokoro, Makoto ; Yanagihara, Naohisa ; Sakurai, Hiromu ; Kojima, Yoshitane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-c1df2c1cea6525fa3b807d12aa8210cfaed9a96ee788af9629619dea0f2e335e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ueda, Eriko</creatorcontrib><creatorcontrib>Yoshikawa, Yutaka</creatorcontrib><creatorcontrib>Kishimoto, Noriko</creatorcontrib><creatorcontrib>Tadokoro, Makoto</creatorcontrib><creatorcontrib>Yanagihara, Naohisa</creatorcontrib><creatorcontrib>Sakurai, Hiromu</creatorcontrib><creatorcontrib>Kojima, Yoshitane</creatorcontrib><collection>CrossRef</collection><jtitle>Chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ueda, Eriko</au><au>Yoshikawa, Yutaka</au><au>Kishimoto, Noriko</au><au>Tadokoro, Makoto</au><au>Yanagihara, Naohisa</au><au>Sakurai, Hiromu</au><au>Kojima, Yoshitane</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New Insulinomimetic Zinc(II) Complexes of Nicotinamide and its Derivatives: X-ray Structure and Biochemical Activity</atitle><jtitle>Chemistry letters</jtitle><addtitle>Chemistry Letters</addtitle><date>2001</date><risdate>2001</risdate><volume>30</volume><issue>11</issue><spage>1184</spage><epage>1185</epage><pages>1184-1185</pages><issn>0366-7022</issn><eissn>1348-0715</eissn><abstract>Three Zn(II) complexes with nicotinamide(na), nicotinemethylamide(nma), and nicotineethylamide(nea) were found to have in vitro insulinomimetic activities. X-ray structure analysis of [Zn(nea)2(H2O)2(SO4)]n showed that each nitrogen atom of two nea molecules locates trans, and the two water molecules and each oxygen atom of the two sulfates coordinate to a Zn(II) ion, forming an octahedral geometry of Zn(N2O4) unit in an inorganic polymer crystal. The Zn(II) complexes with na, nma, and nea exhibited higher insulinomimetic activities, respective IC50 values (50% inhibition concentration of the complex in the free fatty acids release from rat adipocytes) being 1.34, 1.12, and 0.96 mM, than that of ZnSO4 (IC50 = 1.52 mM).</abstract><pub>The Chemical Society of Japan</pub><doi>10.1246/cl.2001.1184</doi><tpages>2</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0366-7022
ispartof Chemistry letters, 2001, Vol.30 (11), p.1184-1185
issn 0366-7022
1348-0715
language eng
recordid cdi_crossref_primary_10_1246_cl_2001_1184
source Oxford University Press Journals All Titles (1996-Current)
title New Insulinomimetic Zinc(II) Complexes of Nicotinamide and its Derivatives: X-ray Structure and Biochemical Activity
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T17%3A02%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-chemicalsocietyjapan_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=New%20Insulinomimetic%20Zinc(II)%20Complexes%20of%20Nicotinamide%20and%20its%20Derivatives:%20X-ray%20Structure%20and%20Biochemical%20Activity&rft.jtitle=Chemistry%20letters&rft.au=Ueda,%20Eriko&rft.date=2001&rft.volume=30&rft.issue=11&rft.spage=1184&rft.epage=1185&rft.pages=1184-1185&rft.issn=0366-7022&rft.eissn=1348-0715&rft_id=info:doi/10.1246/cl.2001.1184&rft_dat=%3Cchemicalsocietyjapan_cross%3E10_1246_cl_2001_1184%3C/chemicalsocietyjapan_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true