Synthetic Studies toward Potent Cytotoxic Agent Amphidinolide B : Synthesis of the Entire C14-C26 Moiety of the Top Half
Regioselective hydroboration of a 4-methyl-2-alkene, oxidation of the resulting mixture of isomeric alcohols, and finally diastereoselective reduction of the ketone are the key steps in the stereoselective synthesis of C19-C26 fragment of amphidinolide B which was coupled with the C14-C18 fragment l...
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Veröffentlicht in: | Chemistry letters 1997-06, Vol.26 (6), p.563-564 |
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creator | Chakraborty, Tushar K Thippeswamy, Devasamudram Suresh, Vayalakkada R Jayaprakash, Sarva |
description | Regioselective hydroboration of a 4-methyl-2-alkene, oxidation of the resulting mixture of isomeric alcohols, and finally diastereoselective reduction of the ketone are the key steps in the stereoselective synthesis of C19-C26 fragment of amphidinolide B which was coupled with the C14-C18 fragment leading to the first synthesis of the entire C14-C26 moiety of this important molecule. |
doi_str_mv | 10.1246/cl.1997.563 |
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ispartof | Chemistry letters, 1997-06, Vol.26 (6), p.563-564 |
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source | Oxford University Press Journals All Titles (1996-Current) |
title | Synthetic Studies toward Potent Cytotoxic Agent Amphidinolide B : Synthesis of the Entire C14-C26 Moiety of the Top Half |
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