COPI-mediated retrieval of SCAP is critical for regulating lipogenesis under basal and sterol-deficient conditions

Retrograde trafficking from the Golgi apparatus to endoplasmic reticulum (ER) via COPI-coated vesicles has been implicated in lipid homeostasis. Here we found that a block in COPI-dependent retrograde trafficking promoted processing and nuclear translocation of SREBPs (sterol regulatory element bind...

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Veröffentlicht in:	Journal of cell science 2015-01
Hauptverfasser:	Takashima, Kouhei, Saitoh, Akina, Funabashi, Teruki, Hirose, Shohei, Yagi, Chikako, Nozaki, Shohei, Sato, Ryuichiro, Shin, Hye-Won, Nakayama, Kazuhisa
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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