Expression of OA1 limits the fusion of a subset of MVBs with lysosomes; a mechanism likely involved in the initial biogenesis of melanosomes

Multivesicular endosomes/bodies (MVBs) deliver proteins like activated EGF receptors (EGFR) to the lysosome for degradation, and, in pigmented cells, MVBs containing PMEL are an initial stage in melanosome biogenesis. The mechanisms regulating numbers and fate of different populations of MVB are unc...

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Veröffentlicht in:	Journal of cell science 2013-01
Hauptverfasser:	Burgoyne, T., Jolly, R., Martin-Martin, B., Seabra, M. C., Piccirillo, R., Schiaffino, M. V., Futter, C. E.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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