EZH2 is required for parathyroid and thymic development through differentiation of the third pharyngeal pouch endoderm

The Ezh2 gene encodes a histone methyltransferase of the polycomb repressive complex 2 that methylates histone H3 lysine 27. In this study, we investigated whether EZH2 has a role in the development of the pharyngeal apparatus and whether it regulates the expression of the Tbx1 gene, which encodes a...

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Veröffentlicht in:	Disease models & mechanisms 2021-03, Vol.14 (3), Article 046789
Hauptverfasser:	Caprio, Cinzia, Lania, Gabriella, Bilio, Marchesa, Ferrentino, Rosa, Chen, Li, Baldini, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Animals Antibodies Cardiomyocytes Cell Biology Cell Differentiation Cloning CRISPR Embryos Endoderm Experiments ezh2 Gene expression Gene Expression Regulation, Developmental Gene loci Life Sciences & Biomedicine Mice Morphogenesis - genetics Organogenesis parathyroids Pathology pharyngeal endoderm Proteins Protocol Science & Technology Stem cells T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism tbx1
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