The transcriptional repressor Bcl6 promotes pre-TCR induced differentiation to CD4+CD8+ thymocyte and attenuates Notch1 activation

Pre-TCR signal transduction is required for developing thymocytes to differentiate from CD4-CD8- double negative (DN) to CD4+CD8+ double positive (DP) cell. Notch signalling is required for T-cell fate specification and must be maintained throughout β-selection, but inappropriate Notch activation in...

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Veröffentlicht in:	Development (Cambridge) 2020-01
Hauptverfasser:	Solanki, Anisha, Yánez, Diana C, Lau, Ching-In, Rowell, Jasmine, Barbarulo, Alessandro, Ross, Susan, Sahni, Hemant, Crompton, Tessa
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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