Potential and Limitations of the New P2Y12 Inhibitor, Cangrelor, in Preventing Heparin-Induced Platelet Aggregation During Cardiac Surgery: An In Vitro Study

BACKGROUND:Heparin-induced thrombocytopenia (HIT) can put cardiac surgery patients at a high risk of lethal complications. If anti-PF4/heparin antibodies (anti-PF4/Hep Abs) are present, 2 strategies exist to prevent intraoperative aggregation during bypass surgeryfirst, using an alternative anticoag...

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Veröffentlicht in:	Anesthesia and analgesia 2020-08, Vol.131 (2), p.622-630
Hauptverfasser:	Scala, Emmanuelle, Gerschheimer, Christiane, Gomez, Francisco J, Alberio, Lorenzo, Marcucci, Carlo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Monophosphate - analogs & derivatives Adenosine Monophosphate - blood Adenosine Monophosphate - pharmacology Anticoagulants - adverse effects Anticoagulants - blood Cardiac Surgical Procedures - adverse effects Cardiac Surgical Procedures - methods Heparin - adverse effects Heparin - blood Humans Platelet Aggregation - drug effects Platelet Aggregation - physiology Purinergic P2Y Receptor Antagonists - blood Purinergic P2Y Receptor Antagonists - pharmacology Receptors, Purinergic P2Y12 - blood
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