The Effects of Epidural Anesthesia on Growth of Escherichia coli at Pseudosurgical Site: The Roles of the Lipocalin-2 Pathway

BACKGROUND:Neutrophil-derived lipocalin-2 exerts bacteriostatic effects through retardation of iron uptake by the Gram-negative organisms like Escherichia coli. We tested the hypothesis that the expression of lipocalin-2, a bacteriostatic protein, was upregulated by induction of surgical site infect...

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Veröffentlicht in:	Anesthesia and analgesia 2015-07, Vol.121 (1), p.81-89
Hauptverfasser:	Igarashi, Toru, Suzuki, Takeshi, Mori, Katsuya, Inoue, Kei, Seki, Hiroyuki, Yamada, Takashige, Kosugi, Shizuko, Minamishima, Shizuka, Katori, Nobuyuki, Sano, Fumiya, Abe, Takayuki, Morisaki, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia, Epidural - methods Anesthetics, Local - pharmacology Animals Cytokines - blood Disease Models, Animal DNA, Bacterial - metabolism Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli - growth & development Escherichia coli Infections - blood Escherichia coli Infections - microbiology Escherichia coli Infections - prevention & control Host-Pathogen Interactions Inflammation Mediators - blood Lidocaine - pharmacology Lipocalin-2 Lipocalins - blood Lipocalins - genetics Male Rats, Wistar RNA, Messenger - metabolism Signal Transduction - drug effects Surgical Wound Infection - blood Surgical Wound Infection - microbiology Surgical Wound Infection - prevention & control Time Factors Up-Regulation
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