A Neurosteroid Anesthetic, Alphaxalone, Inhibits Nicotinic Acetylcholine Receptors in Cultured Bovine Adrenal Chromaffin Cells

Several lines of evidence suggest that nicotinic acetylcholine receptors (nAChRs) are a target of general anesthetics. Alphaxalone (5α-pregnan-3α-ol-11, 20-dion) is a neurosteroid, which was used clinically for anesthesia, but its effects on the function of nAChRs have not been well investigated. We...

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Veröffentlicht in:	Anesthesia and analgesia 2002-10, Vol.95 (4), p.900-906
Hauptverfasser:	Shiraishi, Munehiro, Shibuya, Izumi, Minami, Kouichiro, Uezono, Yasuhito, Okamoto, Takashi, Yanagihara, Nobuyuki, Ueno, Susumu, Ueta, Yoichi, Shigematsu, Akio
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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