Neonatal responses to alphaprodine administered during labor
The effect of intravenously administered alphaprodine on newborn Apgar scores, neonatal acid-base status, and the Neurologic and Adaptive Capacity Scoring System (NACS) were compared in 30 parturients. Patients in group 1 (n = 15) received 20-40 mg increments of alphaprodine, with a total dose of 39...
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| Veröffentlicht in: | Anesthesia and analgesia 1986-04, Vol.65 (4), p.392-394 |
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| container_title | Anesthesia and analgesia |
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| creator | MURAKAWA, K ABBOUD, T. K YANAGI, T |
| description | The effect of intravenously administered alphaprodine on newborn Apgar scores, neonatal acid-base status, and the Neurologic and Adaptive Capacity Scoring System (NACS) were compared in 30 parturients. Patients in group 1 (n = 15) received 20-40 mg increments of alphaprodine, with a total dose of 39.3 +/- 3.7 mg (mean +/- SEM). Group 2 patients (n = 15) received no medication during labor. Apgar scores, neonatal acid-base status, and the NACS were equally good in the two groups. The concentrations of alphaprodine in maternal vein, umbilical vein, and umbilical artery at delivery were measured using a gas-chromographic mass spectrophotometric technique. The results showed an umbilical vein-to-maternal vein ratio of 0.52 +/- 0.09. It is concluded that when administered as in this study, alphaprodine has no adverse effects on the neonate. |
| doi_str_mv | 10.1213/00000539-198604000-00017 |
| format | Article |
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K ; YANAGI, T</creator><creatorcontrib>MURAKAWA, K ; ABBOUD, T. K ; YANAGI, T</creatorcontrib><description>The effect of intravenously administered alphaprodine on newborn Apgar scores, neonatal acid-base status, and the Neurologic and Adaptive Capacity Scoring System (NACS) were compared in 30 parturients. Patients in group 1 (n = 15) received 20-40 mg increments of alphaprodine, with a total dose of 39.3 +/- 3.7 mg (mean +/- SEM). Group 2 patients (n = 15) received no medication during labor. Apgar scores, neonatal acid-base status, and the NACS were equally good in the two groups. The concentrations of alphaprodine in maternal vein, umbilical vein, and umbilical artery at delivery were measured using a gas-chromographic mass spectrophotometric technique. The results showed an umbilical vein-to-maternal vein ratio of 0.52 +/- 0.09. It is concluded that when administered as in this study, alphaprodine has no adverse effects on the neonate.</description><identifier>ISSN: 0003-2999</identifier><identifier>EISSN: 1526-7598</identifier><identifier>DOI: 10.1213/00000539-198604000-00017</identifier><identifier>PMID: 3954114</identifier><identifier>CODEN: AACRAT</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adult ; Alphaprodine - adverse effects ; Alphaprodine - metabolism ; Analgesics ; Anesthesia, Obstetrical - adverse effects ; Apgar Score ; Biological and medical sciences ; Female ; Fetus - drug effects ; Humans ; Infant, Newborn ; Labor, Obstetric ; Medical sciences ; Neuropharmacology ; Pharmacology. 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K</creatorcontrib><creatorcontrib>YANAGI, T</creatorcontrib><title>Neonatal responses to alphaprodine administered during labor</title><title>Anesthesia and analgesia</title><addtitle>Anesth Analg</addtitle><description>The effect of intravenously administered alphaprodine on newborn Apgar scores, neonatal acid-base status, and the Neurologic and Adaptive Capacity Scoring System (NACS) were compared in 30 parturients. Patients in group 1 (n = 15) received 20-40 mg increments of alphaprodine, with a total dose of 39.3 +/- 3.7 mg (mean +/- SEM). Group 2 patients (n = 15) received no medication during labor. Apgar scores, neonatal acid-base status, and the NACS were equally good in the two groups. The concentrations of alphaprodine in maternal vein, umbilical vein, and umbilical artery at delivery were measured using a gas-chromographic mass spectrophotometric technique. The results showed an umbilical vein-to-maternal vein ratio of 0.52 +/- 0.09. It is concluded that when administered as in this study, alphaprodine has no adverse effects on the neonate.</description><subject>Adult</subject><subject>Alphaprodine - adverse effects</subject><subject>Alphaprodine - metabolism</subject><subject>Analgesics</subject><subject>Anesthesia, Obstetrical - adverse effects</subject><subject>Apgar Score</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fetus - drug effects</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Labor, Obstetric</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pregnancy</subject><issn>0003-2999</issn><issn>1526-7598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LxDAQhoMo67r6E4QcvEaTpkkT8CKLq8KiFz2XyZdWum1Jugf_vVm3dmCYz3dgHoQwo7esYPyOHkxwTZhWkpa5INlZdYKWTBSSVEKrU7TMPU4KrfU5ukjp-7BClVygBdeiZKxcovtX33cwQoujT0PfJZ_w2GNohy8YYu-azmNwu6Zr0uijd9jtY9N94hZMHy_RWYA2-asprtDH5vF9_Uy2b08v64ctsVzpkTjqKml5Ka3RAYwxpZPBVSawwAtecSi0yxl45rUqpBC-NIoLHyx1Ij_JV0gd79rYpxR9qIfY7CD-1IzWBx71P4965lH_8cjS66N02Judd7NwApDnN9MckoU2ROhsk-Y1JZmkFeO_AXxong</recordid><startdate>19860401</startdate><enddate>19860401</enddate><creator>MURAKAWA, K</creator><creator>ABBOUD, T. K</creator><creator>YANAGI, T</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19860401</creationdate><title>Neonatal responses to alphaprodine administered during labor</title><author>MURAKAWA, K ; ABBOUD, T. K ; YANAGI, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-d0d76c346cb9fabbb4d6fd7bf1f32373a29df32ae1e982655e4b835efc0d55393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adult</topic><topic>Alphaprodine - adverse effects</topic><topic>Alphaprodine - metabolism</topic><topic>Analgesics</topic><topic>Anesthesia, Obstetrical - adverse effects</topic><topic>Apgar Score</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Fetus - drug effects</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Labor, Obstetric</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MURAKAWA, K</creatorcontrib><creatorcontrib>ABBOUD, T. K</creatorcontrib><creatorcontrib>YANAGI, T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Anesthesia and analgesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MURAKAWA, K</au><au>ABBOUD, T. K</au><au>YANAGI, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neonatal responses to alphaprodine administered during labor</atitle><jtitle>Anesthesia and analgesia</jtitle><addtitle>Anesth Analg</addtitle><date>1986-04-01</date><risdate>1986</risdate><volume>65</volume><issue>4</issue><spage>392</spage><epage>394</epage><pages>392-394</pages><issn>0003-2999</issn><eissn>1526-7598</eissn><coden>AACRAT</coden><abstract>The effect of intravenously administered alphaprodine on newborn Apgar scores, neonatal acid-base status, and the Neurologic and Adaptive Capacity Scoring System (NACS) were compared in 30 parturients. Patients in group 1 (n = 15) received 20-40 mg increments of alphaprodine, with a total dose of 39.3 +/- 3.7 mg (mean +/- SEM). Group 2 patients (n = 15) received no medication during labor. Apgar scores, neonatal acid-base status, and the NACS were equally good in the two groups. The concentrations of alphaprodine in maternal vein, umbilical vein, and umbilical artery at delivery were measured using a gas-chromographic mass spectrophotometric technique. The results showed an umbilical vein-to-maternal vein ratio of 0.52 +/- 0.09. It is concluded that when administered as in this study, alphaprodine has no adverse effects on the neonate.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>3954114</pmid><doi>10.1213/00000539-198604000-00017</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Anesthesia and analgesia, 1986-04, Vol.65 (4), p.392-394 |
| issn | 0003-2999 1526-7598 |
| language | eng |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; EZB-FREE-00999 freely available EZB journals; Journals@Ovid Complete |
| subjects | Adult Alphaprodine - adverse effects Alphaprodine - metabolism Analgesics Anesthesia, Obstetrical - adverse effects Apgar Score Biological and medical sciences Female Fetus - drug effects Humans Infant, Newborn Labor, Obstetric Medical sciences Neuropharmacology Pharmacology. Drug treatments Pregnancy |
| title | Neonatal responses to alphaprodine administered during labor |
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