Nitrous oxide, too, is hepatotoxic in rats

Anesthetic hepatotoxicity was tested under various conditions of hypoxia in rats pretreated with phenobarbital. Administration of 0.3 MAC halothane or fentanyl in 9% oxygen (fractional concentration of inspired oxygen = 0.09) for 46 min produced centrilobular hepatic injury in all rats (P less than...

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Veröffentlicht in:	Anesthesia and analgesia 1984-12, Vol.63 (12), p.1076-1080
Hauptverfasser:	FASSOULAKI, A, EGER, E. I. II, JOHNSON, B. H, FERRELL, L. D, SMUCKLER, E. A, HARPER, M. H, EGER, R. R, CAHALAN, M. K
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics. Neuromuscular blocking agents Animals Biological and medical sciences Fentanyl - toxicity Halothane - toxicity Hypoxia - pathology Isoflurane - toxicity Liver - drug effects Male Medical sciences Neuropharmacology Nitrous Oxide - toxicity Pharmacology. Drug treatments Rats Rats, Inbred Strains Thiopental - toxicity
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