Developmental toxicity of methoxyflurane in mice
The developmental toxicity of trace, subanesthetic, and anesthetic exposure to methoxyflurane was examined in Swiss/ICR mice. No adverse effects on reproduction or fetal development were demonstrated following exposure to trace (2 ppm) and subanesthetic (60 ppm) concentrations of methoxyflurane for...
Gespeichert in:
| Veröffentlicht in: | Anesthesia and analgesia 1980-06, Vol.59 (6), p.421-425 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 425 |
|---|---|
| container_issue | 6 |
| container_start_page | 421 |
| container_title | Anesthesia and analgesia |
| container_volume | 59 |
| creator | Wharton, R S Sievenpiper, T S Mazze, R I |
| description | The developmental toxicity of trace, subanesthetic, and anesthetic exposure to methoxyflurane was examined in Swiss/ICR mice. No adverse effects on reproduction or fetal development were demonstrated following exposure to trace (2 ppm) and subanesthetic (60 ppm) concentrations of methoxyflurane for 4 hours daily on days 6 through 15 of pregnancy. Exposure to an anesthetic concentration (2000 ppm; 0.2%) for the same period resulted in decreased fetal weight, decreased ossification, and delayed renal maturation. Additionally, the incidence of minor skeletal anomalies was increased. It is concluded that gestational exposure of mice to trace of subanesthetic concentrations of methoxyflurane does not result in reproductive loss or morphologic abnormalities in their offspring. |
| doi_str_mv | 10.1213/00000539-198006000-00006 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1213_00000539_198006000_00006</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>7189979</sourcerecordid><originalsourceid>FETCH-LOGICAL-c310t-ebdfb893d8ecfeabdfcb63cee0997357ea8bb1f981534cf9d11fea9fae3642b03</originalsourceid><addsrcrecordid>eNo9j81OwzAQhH0AlVJ4BCS_gMEbN473iMpPkSpxgXNkO2sRlD8lKWreHoeW7mU0o51dfYxxkPeQgHqQ86QKBaCRUkcj5kRfsGUUJRJEvGLXw_AdLUijF2yRgUHMcMnkE_1Q1XY1NaOt-NgeSl-OE28Dr2n8ag9TqPa9bYiXDa9LTzfsMthqoNuTrtjny_PHZit2769vm8ed8ArkKMgVwRlUhSEfyEbnnVaeSMa_Ks3IGucgoIFUrX3AAiCuYbCk9DpxUq2YOd71fTsMPYW868va9lMOMp-583_u_Mz9F-lYvTtWu72rqTgXT9DqFxMBVts</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Developmental toxicity of methoxyflurane in mice</title><source>MEDLINE</source><source>Journals@Ovid LWW Legacy Archive</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Journals@Ovid Complete</source><creator>Wharton, R S ; Sievenpiper, T S ; Mazze, R I</creator><creatorcontrib>Wharton, R S ; Sievenpiper, T S ; Mazze, R I</creatorcontrib><description>The developmental toxicity of trace, subanesthetic, and anesthetic exposure to methoxyflurane was examined in Swiss/ICR mice. No adverse effects on reproduction or fetal development were demonstrated following exposure to trace (2 ppm) and subanesthetic (60 ppm) concentrations of methoxyflurane for 4 hours daily on days 6 through 15 of pregnancy. Exposure to an anesthetic concentration (2000 ppm; 0.2%) for the same period resulted in decreased fetal weight, decreased ossification, and delayed renal maturation. Additionally, the incidence of minor skeletal anomalies was increased. It is concluded that gestational exposure of mice to trace of subanesthetic concentrations of methoxyflurane does not result in reproductive loss or morphologic abnormalities in their offspring.</description><identifier>ISSN: 0003-2999</identifier><identifier>DOI: 10.1213/00000539-198006000-00006</identifier><identifier>PMID: 7189979</identifier><language>eng</language><publisher>United States</publisher><subject>Abnormalities, Drug-Induced ; Animals ; Body Weight - drug effects ; Female ; Fetal Viability - drug effects ; Fetus - drug effects ; Kidney - drug effects ; Male ; Methoxyflurane - toxicity ; Mice ; Osteogenesis - drug effects ; Pregnancy - drug effects ; Skeleton - abnormalities</subject><ispartof>Anesthesia and analgesia, 1980-06, Vol.59 (6), p.421-425</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c310t-ebdfb893d8ecfeabdfcb63cee0997357ea8bb1f981534cf9d11fea9fae3642b03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7189979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wharton, R S</creatorcontrib><creatorcontrib>Sievenpiper, T S</creatorcontrib><creatorcontrib>Mazze, R I</creatorcontrib><title>Developmental toxicity of methoxyflurane in mice</title><title>Anesthesia and analgesia</title><addtitle>Anesth Analg</addtitle><description>The developmental toxicity of trace, subanesthetic, and anesthetic exposure to methoxyflurane was examined in Swiss/ICR mice. No adverse effects on reproduction or fetal development were demonstrated following exposure to trace (2 ppm) and subanesthetic (60 ppm) concentrations of methoxyflurane for 4 hours daily on days 6 through 15 of pregnancy. Exposure to an anesthetic concentration (2000 ppm; 0.2%) for the same period resulted in decreased fetal weight, decreased ossification, and delayed renal maturation. Additionally, the incidence of minor skeletal anomalies was increased. It is concluded that gestational exposure of mice to trace of subanesthetic concentrations of methoxyflurane does not result in reproductive loss or morphologic abnormalities in their offspring.</description><subject>Abnormalities, Drug-Induced</subject><subject>Animals</subject><subject>Body Weight - drug effects</subject><subject>Female</subject><subject>Fetal Viability - drug effects</subject><subject>Fetus - drug effects</subject><subject>Kidney - drug effects</subject><subject>Male</subject><subject>Methoxyflurane - toxicity</subject><subject>Mice</subject><subject>Osteogenesis - drug effects</subject><subject>Pregnancy - drug effects</subject><subject>Skeleton - abnormalities</subject><issn>0003-2999</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j81OwzAQhH0AlVJ4BCS_gMEbN473iMpPkSpxgXNkO2sRlD8lKWreHoeW7mU0o51dfYxxkPeQgHqQ86QKBaCRUkcj5kRfsGUUJRJEvGLXw_AdLUijF2yRgUHMcMnkE_1Q1XY1NaOt-NgeSl-OE28Dr2n8ag9TqPa9bYiXDa9LTzfsMthqoNuTrtjny_PHZit2769vm8ed8ArkKMgVwRlUhSEfyEbnnVaeSMa_Ks3IGucgoIFUrX3AAiCuYbCk9DpxUq2YOd71fTsMPYW868va9lMOMp-583_u_Mz9F-lYvTtWu72rqTgXT9DqFxMBVts</recordid><startdate>198006</startdate><enddate>198006</enddate><creator>Wharton, R S</creator><creator>Sievenpiper, T S</creator><creator>Mazze, R I</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198006</creationdate><title>Developmental toxicity of methoxyflurane in mice</title><author>Wharton, R S ; Sievenpiper, T S ; Mazze, R I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c310t-ebdfb893d8ecfeabdfcb63cee0997357ea8bb1f981534cf9d11fea9fae3642b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Abnormalities, Drug-Induced</topic><topic>Animals</topic><topic>Body Weight - drug effects</topic><topic>Female</topic><topic>Fetal Viability - drug effects</topic><topic>Fetus - drug effects</topic><topic>Kidney - drug effects</topic><topic>Male</topic><topic>Methoxyflurane - toxicity</topic><topic>Mice</topic><topic>Osteogenesis - drug effects</topic><topic>Pregnancy - drug effects</topic><topic>Skeleton - abnormalities</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wharton, R S</creatorcontrib><creatorcontrib>Sievenpiper, T S</creatorcontrib><creatorcontrib>Mazze, R I</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Anesthesia and analgesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wharton, R S</au><au>Sievenpiper, T S</au><au>Mazze, R I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Developmental toxicity of methoxyflurane in mice</atitle><jtitle>Anesthesia and analgesia</jtitle><addtitle>Anesth Analg</addtitle><date>1980-06</date><risdate>1980</risdate><volume>59</volume><issue>6</issue><spage>421</spage><epage>425</epage><pages>421-425</pages><issn>0003-2999</issn><abstract>The developmental toxicity of trace, subanesthetic, and anesthetic exposure to methoxyflurane was examined in Swiss/ICR mice. No adverse effects on reproduction or fetal development were demonstrated following exposure to trace (2 ppm) and subanesthetic (60 ppm) concentrations of methoxyflurane for 4 hours daily on days 6 through 15 of pregnancy. Exposure to an anesthetic concentration (2000 ppm; 0.2%) for the same period resulted in decreased fetal weight, decreased ossification, and delayed renal maturation. Additionally, the incidence of minor skeletal anomalies was increased. It is concluded that gestational exposure of mice to trace of subanesthetic concentrations of methoxyflurane does not result in reproductive loss or morphologic abnormalities in their offspring.</abstract><cop>United States</cop><pmid>7189979</pmid><doi>10.1213/00000539-198006000-00006</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-2999 |
| ispartof | Anesthesia and analgesia, 1980-06, Vol.59 (6), p.421-425 |
| issn | 0003-2999 |
| language | eng |
| recordid | cdi_crossref_primary_10_1213_00000539_198006000_00006 |
| source | MEDLINE; Journals@Ovid LWW Legacy Archive; EZB-FREE-00999 freely available EZB journals; Journals@Ovid Complete |
| subjects | Abnormalities, Drug-Induced Animals Body Weight - drug effects Female Fetal Viability - drug effects Fetus - drug effects Kidney - drug effects Male Methoxyflurane - toxicity Mice Osteogenesis - drug effects Pregnancy - drug effects Skeleton - abnormalities |
| title | Developmental toxicity of methoxyflurane in mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T20%3A25%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Developmental%20toxicity%20of%20methoxyflurane%20in%20mice&rft.jtitle=Anesthesia%20and%20analgesia&rft.au=Wharton,%20R%20S&rft.date=1980-06&rft.volume=59&rft.issue=6&rft.spage=421&rft.epage=425&rft.pages=421-425&rft.issn=0003-2999&rft_id=info:doi/10.1213/00000539-198006000-00006&rft_dat=%3Cpubmed_cross%3E7189979%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/7189979&rfr_iscdi=true |