Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities, and its comparison with azole antifungal drugs

The effects of micafungin on cytochrome P450 3A4 (CYP3A4) metabolic and multidrug resistance protein 1 (MDR1) transport activities were investigated and compared with those of amphotericin B and four azole antifungal drugs (ketoconazole, itraconazole, fluconazole and miconazole). The effects on the...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2005-06, Vol.57 (6), p.759-764
Hauptverfasser:	Sakaeda, Toshiyuki, Iwaki, Koichi, Kakumoto, Mikio, Nishikawa, Mika, Niwa, Toshiro, Jin, Jiang-shu, Nakamura, Tsutomu, Nishiguchi, Kohshi, Okamura, Noboru, Okumura, Katsuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antifungal Agents - pharmacology ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism Azoles - pharmacology Biological Transport Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - metabolism Echinocandins Humans In Vitro Techniques Inhibitory Concentration 50 Lipopeptides Lipoproteins - pharmacology Micafungin Microsomes, Liver - metabolism Peptides, Cyclic - pharmacology Swine
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