Effects of L-carnitine treatment on oxidant/antioxidant state and vascular reactivity of streptozotocin-diabetic rat aorta
ABSTRACT In this study, the effects of L‐carnitine treatment on lipids, lipid peroxidation of plasma, reactivity and antioxidant enzyme activity of aorta were evaluated in streptozotocin (STZ)‐diabetic rats. Treatment with L‐carnitine (0.6 g kg−1 daily, i.p.) was started 8 weeks after the induction...
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description | ABSTRACT
In this study, the effects of L‐carnitine treatment on lipids, lipid peroxidation of plasma, reactivity and antioxidant enzyme activity of aorta were evaluated in streptozotocin (STZ)‐diabetic rats. Treatment with L‐carnitine (0.6 g kg−1 daily, i.p.) was started 8 weeks after the induction of diabetes and continued for 2 weeks. Diabetes was induced by a single injection of streptozotocin (45 mg kg−1, i.p.). Plasma cholesterol, triglyceride and thiobarbituric acid reactive substance (TBARS) levels and blood glucose levels were significantly increased, although free carnitine levels were markedly decreased in diabetic rats. L‐Carnitine treatment completely normalized plasma cholesterol, triglyceride, free carnitine and TBARS levels but partially restored blood glucose levels of diabetic rats. STZ‐diabetes caused a significant reduction in the endothelium‐dependent relaxation response to acetylcholine (ACh). In diabetic aorta, TBARS levels and catalase (CAT) activity were significantly increased but glutathione peroxidase (GSH‐Px) activity was unchanged. Treatment of diabetic rats with L‐carnitine resulted in partial restoration of the endothelium‐dependent relaxation response to ACh and completely normalized the oxidant/antioxidant state. These results suggested that the beneficial effects of L‐carnitine treatment partially improve vascular reactivity and antioxidant property beyond its reduction of plasma lipids and it may have an important therapeutic approach in the treatment of diabetic vascular complications. |
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In this study, the effects of L‐carnitine treatment on lipids, lipid peroxidation of plasma, reactivity and antioxidant enzyme activity of aorta were evaluated in streptozotocin (STZ)‐diabetic rats. Treatment with L‐carnitine (0.6 g kg−1 daily, i.p.) was started 8 weeks after the induction of diabetes and continued for 2 weeks. Diabetes was induced by a single injection of streptozotocin (45 mg kg−1, i.p.). Plasma cholesterol, triglyceride and thiobarbituric acid reactive substance (TBARS) levels and blood glucose levels were significantly increased, although free carnitine levels were markedly decreased in diabetic rats. L‐Carnitine treatment completely normalized plasma cholesterol, triglyceride, free carnitine and TBARS levels but partially restored blood glucose levels of diabetic rats. STZ‐diabetes caused a significant reduction in the endothelium‐dependent relaxation response to acetylcholine (ACh). In diabetic aorta, TBARS levels and catalase (CAT) activity were significantly increased but glutathione peroxidase (GSH‐Px) activity was unchanged. Treatment of diabetic rats with L‐carnitine resulted in partial restoration of the endothelium‐dependent relaxation response to ACh and completely normalized the oxidant/antioxidant state. These results suggested that the beneficial effects of L‐carnitine treatment partially improve vascular reactivity and antioxidant property beyond its reduction of plasma lipids and it may have an important therapeutic approach in the treatment of diabetic vascular complications.</description><identifier>ISSN: 0022-3573</identifier><identifier>EISSN: 2042-7158</identifier><identifier>DOI: 10.1211/0022357021909</identifier><identifier>PMID: 14607021</identifier><identifier>CODEN: JPPMAB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acetylcholine - pharmacology ; Animals ; Antioxidants - pharmacology ; Aorta - drug effects ; Aorta - physiology ; Associated diseases and complications ; Biological and medical sciences ; Blood Glucose ; Carnitine - pharmacology ; Catalase - pharmacology ; Diabetes Mellitus, Experimental - physiopathology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Lipid Metabolism ; Lipid Peroxidation ; Male ; Medical sciences ; Oxidants - pharmacology ; Rats ; Rats, Wistar ; Streptozocin ; Vascular Resistance - drug effects ; Vascular Resistance - physiology ; Vasodilation - drug effects ; Vasodilation - physiology</subject><ispartof>Journal of pharmacy and pharmacology, 2003-10, Vol.55 (10), p.1389-1395</ispartof><rights>2003 Royal Pharmaceutical Society of Great Britain</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4404-8d4540888a3c43e7f5873dcf845bafc5cd1c10ea308a3e73a0f2dc47269a408d3</citedby><cites>FETCH-LOGICAL-c4404-8d4540888a3c43e7f5873dcf845bafc5cd1c10ea308a3e73a0f2dc47269a408d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1211%2F0022357021909$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1211%2F0022357021909$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15198811$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14607021$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Irat, Ali Murat</creatorcontrib><creatorcontrib>Aktan, Fügen</creatorcontrib><creatorcontrib>Ozansoy, Gülgün</creatorcontrib><title>Effects of L-carnitine treatment on oxidant/antioxidant state and vascular reactivity of streptozotocin-diabetic rat aorta</title><title>Journal of pharmacy and pharmacology</title><addtitle>J Pharm Pharmacol</addtitle><description>ABSTRACT
In this study, the effects of L‐carnitine treatment on lipids, lipid peroxidation of plasma, reactivity and antioxidant enzyme activity of aorta were evaluated in streptozotocin (STZ)‐diabetic rats. Treatment with L‐carnitine (0.6 g kg−1 daily, i.p.) was started 8 weeks after the induction of diabetes and continued for 2 weeks. Diabetes was induced by a single injection of streptozotocin (45 mg kg−1, i.p.). Plasma cholesterol, triglyceride and thiobarbituric acid reactive substance (TBARS) levels and blood glucose levels were significantly increased, although free carnitine levels were markedly decreased in diabetic rats. L‐Carnitine treatment completely normalized plasma cholesterol, triglyceride, free carnitine and TBARS levels but partially restored blood glucose levels of diabetic rats. STZ‐diabetes caused a significant reduction in the endothelium‐dependent relaxation response to acetylcholine (ACh). In diabetic aorta, TBARS levels and catalase (CAT) activity were significantly increased but glutathione peroxidase (GSH‐Px) activity was unchanged. Treatment of diabetic rats with L‐carnitine resulted in partial restoration of the endothelium‐dependent relaxation response to ACh and completely normalized the oxidant/antioxidant state. These results suggested that the beneficial effects of L‐carnitine treatment partially improve vascular reactivity and antioxidant property beyond its reduction of plasma lipids and it may have an important therapeutic approach in the treatment of diabetic vascular complications.</description><subject>Acetylcholine - pharmacology</subject><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Aorta - drug effects</subject><subject>Aorta - physiology</subject><subject>Associated diseases and complications</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose</subject><subject>Carnitine - pharmacology</subject><subject>Catalase - pharmacology</subject><subject>Diabetes Mellitus, Experimental - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Lipid Metabolism</subject><subject>Lipid Peroxidation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Oxidants - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Streptozocin</subject><subject>Vascular Resistance - drug effects</subject><subject>Vascular Resistance - physiology</subject><subject>Vasodilation - drug effects</subject><subject>Vasodilation - physiology</subject><issn>0022-3573</issn><issn>2042-7158</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtvUzEQhS0EakPpki3yhuWl49e1s0RV24Cq0kVbltbED8mQ3BvZ7iP99fgqEREbFtZYmu-cmTmEfGTwhXHGzgA4F0oDZ3OYvyEzDpJ3minzlsymXtea4pi8L-UXAOi-74_IMZM9TJIZeb2IMbha6BjpdecwD6mmIdCaA9Z1GCodBzq-JI9DPWsv7f-0VKyB4uDpExb3uMJMm8TV9JTqdnIrzWJTx9exji4NnU-4DDU5mrFSHHPFD-RdxFUJp_t6Qu4vL-7OF931j6tv51_bNlKC7IyXSoIxBoWTIuiojBbeRSPVEqNTzjPHIKCARgQtECL3Tmrez7HpvDgh3c7X5bGUHKLd5LTGvLUM7JSh_SfDxn_a8ZvH5Tr4A70PrQGf90C7HFcx4-BSOXCKzY1hEyd23HNahe3_p9rvt4tb3i49rJtKDS9_VZh_214LrezPmyt7I-VCweWDfRB_ABspmNs</recordid><startdate>200310</startdate><enddate>200310</enddate><creator>Irat, Ali Murat</creator><creator>Aktan, Fügen</creator><creator>Ozansoy, Gülgün</creator><general>Blackwell Publishing Ltd</general><general>Pharmaceutical Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200310</creationdate><title>Effects of L-carnitine treatment on oxidant/antioxidant state and vascular reactivity of streptozotocin-diabetic rat aorta</title><author>Irat, Ali Murat ; Aktan, Fügen ; Ozansoy, Gülgün</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4404-8d4540888a3c43e7f5873dcf845bafc5cd1c10ea308a3e73a0f2dc47269a408d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Aorta - drug effects</topic><topic>Aorta - physiology</topic><topic>Associated diseases and complications</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose</topic><topic>Carnitine - pharmacology</topic><topic>Catalase - pharmacology</topic><topic>Diabetes Mellitus, Experimental - physiopathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Lipid Metabolism</topic><topic>Lipid Peroxidation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Oxidants - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Streptozocin</topic><topic>Vascular Resistance - drug effects</topic><topic>Vascular Resistance - physiology</topic><topic>Vasodilation - drug effects</topic><topic>Vasodilation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Irat, Ali Murat</creatorcontrib><creatorcontrib>Aktan, Fügen</creatorcontrib><creatorcontrib>Ozansoy, Gülgün</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of pharmacy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Irat, Ali Murat</au><au>Aktan, Fügen</au><au>Ozansoy, Gülgün</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of L-carnitine treatment on oxidant/antioxidant state and vascular reactivity of streptozotocin-diabetic rat aorta</atitle><jtitle>Journal of pharmacy and pharmacology</jtitle><addtitle>J Pharm Pharmacol</addtitle><date>2003-10</date><risdate>2003</risdate><volume>55</volume><issue>10</issue><spage>1389</spage><epage>1395</epage><pages>1389-1395</pages><issn>0022-3573</issn><eissn>2042-7158</eissn><coden>JPPMAB</coden><abstract>ABSTRACT
In this study, the effects of L‐carnitine treatment on lipids, lipid peroxidation of plasma, reactivity and antioxidant enzyme activity of aorta were evaluated in streptozotocin (STZ)‐diabetic rats. Treatment with L‐carnitine (0.6 g kg−1 daily, i.p.) was started 8 weeks after the induction of diabetes and continued for 2 weeks. Diabetes was induced by a single injection of streptozotocin (45 mg kg−1, i.p.). Plasma cholesterol, triglyceride and thiobarbituric acid reactive substance (TBARS) levels and blood glucose levels were significantly increased, although free carnitine levels were markedly decreased in diabetic rats. L‐Carnitine treatment completely normalized plasma cholesterol, triglyceride, free carnitine and TBARS levels but partially restored blood glucose levels of diabetic rats. STZ‐diabetes caused a significant reduction in the endothelium‐dependent relaxation response to acetylcholine (ACh). In diabetic aorta, TBARS levels and catalase (CAT) activity were significantly increased but glutathione peroxidase (GSH‐Px) activity was unchanged. Treatment of diabetic rats with L‐carnitine resulted in partial restoration of the endothelium‐dependent relaxation response to ACh and completely normalized the oxidant/antioxidant state. These results suggested that the beneficial effects of L‐carnitine treatment partially improve vascular reactivity and antioxidant property beyond its reduction of plasma lipids and it may have an important therapeutic approach in the treatment of diabetic vascular complications.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>14607021</pmid><doi>10.1211/0022357021909</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Acetylcholine - pharmacology Animals Antioxidants - pharmacology Aorta - drug effects Aorta - physiology Associated diseases and complications Biological and medical sciences Blood Glucose Carnitine - pharmacology Catalase - pharmacology Diabetes Mellitus, Experimental - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Lipid Metabolism Lipid Peroxidation Male Medical sciences Oxidants - pharmacology Rats Rats, Wistar Streptozocin Vascular Resistance - drug effects Vascular Resistance - physiology Vasodilation - drug effects Vasodilation - physiology |
title | Effects of L-carnitine treatment on oxidant/antioxidant state and vascular reactivity of streptozotocin-diabetic rat aorta |
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