Effects of L-carnitine treatment on oxidant/antioxidant state and vascular reactivity of streptozotocin-diabetic rat aorta

ABSTRACT In this study, the effects of L‐carnitine treatment on lipids, lipid peroxidation of plasma, reactivity and antioxidant enzyme activity of aorta were evaluated in streptozotocin (STZ)‐diabetic rats. Treatment with L‐carnitine (0.6 g kg−1 daily, i.p.) was started 8 weeks after the induction...

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Veröffentlicht in:Journal of pharmacy and pharmacology 2003-10, Vol.55 (10), p.1389-1395
Hauptverfasser: Irat, Ali Murat, Aktan, Fügen, Ozansoy, Gülgün
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creator Irat, Ali Murat
Aktan, Fügen
Ozansoy, Gülgün
description ABSTRACT In this study, the effects of L‐carnitine treatment on lipids, lipid peroxidation of plasma, reactivity and antioxidant enzyme activity of aorta were evaluated in streptozotocin (STZ)‐diabetic rats. Treatment with L‐carnitine (0.6 g kg−1 daily, i.p.) was started 8 weeks after the induction of diabetes and continued for 2 weeks. Diabetes was induced by a single injection of streptozotocin (45 mg kg−1, i.p.). Plasma cholesterol, triglyceride and thiobarbituric acid reactive substance (TBARS) levels and blood glucose levels were significantly increased, although free carnitine levels were markedly decreased in diabetic rats. L‐Carnitine treatment completely normalized plasma cholesterol, triglyceride, free carnitine and TBARS levels but partially restored blood glucose levels of diabetic rats. STZ‐diabetes caused a significant reduction in the endothelium‐dependent relaxation response to acetylcholine (ACh). In diabetic aorta, TBARS levels and catalase (CAT) activity were significantly increased but glutathione peroxidase (GSH‐Px) activity was unchanged. Treatment of diabetic rats with L‐carnitine resulted in partial restoration of the endothelium‐dependent relaxation response to ACh and completely normalized the oxidant/antioxidant state. These results suggested that the beneficial effects of L‐carnitine treatment partially improve vascular reactivity and antioxidant property beyond its reduction of plasma lipids and it may have an important therapeutic approach in the treatment of diabetic vascular complications.
doi_str_mv 10.1211/0022357021909
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Treatment with L‐carnitine (0.6 g kg−1 daily, i.p.) was started 8 weeks after the induction of diabetes and continued for 2 weeks. Diabetes was induced by a single injection of streptozotocin (45 mg kg−1, i.p.). Plasma cholesterol, triglyceride and thiobarbituric acid reactive substance (TBARS) levels and blood glucose levels were significantly increased, although free carnitine levels were markedly decreased in diabetic rats. L‐Carnitine treatment completely normalized plasma cholesterol, triglyceride, free carnitine and TBARS levels but partially restored blood glucose levels of diabetic rats. STZ‐diabetes caused a significant reduction in the endothelium‐dependent relaxation response to acetylcholine (ACh). In diabetic aorta, TBARS levels and catalase (CAT) activity were significantly increased but glutathione peroxidase (GSH‐Px) activity was unchanged. Treatment of diabetic rats with L‐carnitine resulted in partial restoration of the endothelium‐dependent relaxation response to ACh and completely normalized the oxidant/antioxidant state. These results suggested that the beneficial effects of L‐carnitine treatment partially improve vascular reactivity and antioxidant property beyond its reduction of plasma lipids and it may have an important therapeutic approach in the treatment of diabetic vascular complications.</description><identifier>ISSN: 0022-3573</identifier><identifier>EISSN: 2042-7158</identifier><identifier>DOI: 10.1211/0022357021909</identifier><identifier>PMID: 14607021</identifier><identifier>CODEN: JPPMAB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acetylcholine - pharmacology ; Animals ; Antioxidants - pharmacology ; Aorta - drug effects ; Aorta - physiology ; Associated diseases and complications ; Biological and medical sciences ; Blood Glucose ; Carnitine - pharmacology ; Catalase - pharmacology ; Diabetes Mellitus, Experimental - physiopathology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. 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Treatment with L‐carnitine (0.6 g kg−1 daily, i.p.) was started 8 weeks after the induction of diabetes and continued for 2 weeks. Diabetes was induced by a single injection of streptozotocin (45 mg kg−1, i.p.). Plasma cholesterol, triglyceride and thiobarbituric acid reactive substance (TBARS) levels and blood glucose levels were significantly increased, although free carnitine levels were markedly decreased in diabetic rats. L‐Carnitine treatment completely normalized plasma cholesterol, triglyceride, free carnitine and TBARS levels but partially restored blood glucose levels of diabetic rats. STZ‐diabetes caused a significant reduction in the endothelium‐dependent relaxation response to acetylcholine (ACh). In diabetic aorta, TBARS levels and catalase (CAT) activity were significantly increased but glutathione peroxidase (GSH‐Px) activity was unchanged. Treatment of diabetic rats with L‐carnitine resulted in partial restoration of the endothelium‐dependent relaxation response to ACh and completely normalized the oxidant/antioxidant state. These results suggested that the beneficial effects of L‐carnitine treatment partially improve vascular reactivity and antioxidant property beyond its reduction of plasma lipids and it may have an important therapeutic approach in the treatment of diabetic vascular complications.</description><subject>Acetylcholine - pharmacology</subject><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Aorta - drug effects</subject><subject>Aorta - physiology</subject><subject>Associated diseases and complications</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose</subject><subject>Carnitine - pharmacology</subject><subject>Catalase - pharmacology</subject><subject>Diabetes Mellitus, Experimental - physiopathology</subject><subject>Diabetes. 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Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Lipid Metabolism</subject><subject>Lipid Peroxidation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Oxidants - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Streptozocin</subject><subject>Vascular Resistance - drug effects</subject><subject>Vascular Resistance - physiology</subject><subject>Vasodilation - drug effects</subject><subject>Vasodilation - physiology</subject><issn>0022-3573</issn><issn>2042-7158</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtvUzEQhS0EakPpki3yhuWl49e1s0RV24Cq0kVbltbED8mQ3BvZ7iP99fgqEREbFtZYmu-cmTmEfGTwhXHGzgA4F0oDZ3OYvyEzDpJ3minzlsymXtea4pi8L-UXAOi-74_IMZM9TJIZeb2IMbha6BjpdecwD6mmIdCaA9Z1GCodBzq-JI9DPWsv7f-0VKyB4uDpExb3uMJMm8TV9JTqdnIrzWJTx9exji4NnU-4DDU5mrFSHHPFD-RdxFUJp_t6Qu4vL-7OF931j6tv51_bNlKC7IyXSoIxBoWTIuiojBbeRSPVEqNTzjPHIKCARgQtECL3Tmrez7HpvDgh3c7X5bGUHKLd5LTGvLUM7JSh_SfDxn_a8ZvH5Tr4A70PrQGf90C7HFcx4-BSOXCKzY1hEyd23HNahe3_p9rvt4tb3i49rJtKDS9_VZh_214LrezPmyt7I-VCweWDfRB_ABspmNs</recordid><startdate>200310</startdate><enddate>200310</enddate><creator>Irat, Ali Murat</creator><creator>Aktan, Fügen</creator><creator>Ozansoy, Gülgün</creator><general>Blackwell Publishing Ltd</general><general>Pharmaceutical Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200310</creationdate><title>Effects of L-carnitine treatment on oxidant/antioxidant state and vascular reactivity of streptozotocin-diabetic rat aorta</title><author>Irat, Ali Murat ; Aktan, Fügen ; Ozansoy, Gülgün</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4404-8d4540888a3c43e7f5873dcf845bafc5cd1c10ea308a3e73a0f2dc47269a408d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Aorta - drug effects</topic><topic>Aorta - physiology</topic><topic>Associated diseases and complications</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose</topic><topic>Carnitine - pharmacology</topic><topic>Catalase - pharmacology</topic><topic>Diabetes Mellitus, Experimental - physiopathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Lipid Metabolism</topic><topic>Lipid Peroxidation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Oxidants - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Streptozocin</topic><topic>Vascular Resistance - drug effects</topic><topic>Vascular Resistance - physiology</topic><topic>Vasodilation - drug effects</topic><topic>Vasodilation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Irat, Ali Murat</creatorcontrib><creatorcontrib>Aktan, Fügen</creatorcontrib><creatorcontrib>Ozansoy, Gülgün</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of pharmacy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Irat, Ali Murat</au><au>Aktan, Fügen</au><au>Ozansoy, Gülgün</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of L-carnitine treatment on oxidant/antioxidant state and vascular reactivity of streptozotocin-diabetic rat aorta</atitle><jtitle>Journal of pharmacy and pharmacology</jtitle><addtitle>J Pharm Pharmacol</addtitle><date>2003-10</date><risdate>2003</risdate><volume>55</volume><issue>10</issue><spage>1389</spage><epage>1395</epage><pages>1389-1395</pages><issn>0022-3573</issn><eissn>2042-7158</eissn><coden>JPPMAB</coden><abstract>ABSTRACT In this study, the effects of L‐carnitine treatment on lipids, lipid peroxidation of plasma, reactivity and antioxidant enzyme activity of aorta were evaluated in streptozotocin (STZ)‐diabetic rats. 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source MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current)
subjects Acetylcholine - pharmacology
Animals
Antioxidants - pharmacology
Aorta - drug effects
Aorta - physiology
Associated diseases and complications
Biological and medical sciences
Blood Glucose
Carnitine - pharmacology
Catalase - pharmacology
Diabetes Mellitus, Experimental - physiopathology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Lipid Metabolism
Lipid Peroxidation
Male
Medical sciences
Oxidants - pharmacology
Rats
Rats, Wistar
Streptozocin
Vascular Resistance - drug effects
Vascular Resistance - physiology
Vasodilation - drug effects
Vasodilation - physiology
title Effects of L-carnitine treatment on oxidant/antioxidant state and vascular reactivity of streptozotocin-diabetic rat aorta
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